Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24690055
TITLE
Hepatitis C testing and status among opioid substitution treatment clients in New South Wales.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
In Australia about half of the people who inject drugs (PWID) are hepatitis C (HCV) antibody positive (anti-HCV+). The prevalence among opioid substitution treatment (OST) clients specifically is unclear, despite OST clinics being a potential setting for HCV care. This study aimed to report the prevalence of HCV among a large sample of NSW OST clients, understand whether HCV testing is translating into knowledge of status, and identify the correlates of inaccurate self-reporting of HCV status.
METHODS NlmCategory: METHODS
Participants completed an interview that included self-reported HCV status. Participants also provided a blood sample that was tested for HCV IgG antibodies, and for viral load using a quantitative real-time reverse-transcriptase polymerase chain reaction. Valid interviews and viable blood sample were provided by 1,484 participants. Logistic regression modelling was used to identify independent predictors of knowledge of HCV antibody status.
RESULTS NlmCategory: RESULTS
Overall, 84% of participants were anti-HCV+. Of these, 65% were RNA+. Four per cent of anti-HCV negative participants were RNA+. One-quarter of anti-HCV+ participants did not know their status or reported it incorrectly, compared with 14.5% of anti-HCV negative participants.
CONCLUSION NlmCategory: CONCLUSIONS
The prevalence of HCV in this sample was higher than that found among other samples of people who inject drugs, suggesting the need for greater prevention efforts with OST clients. Anti-HCV+ individuals are less accurate at reporting their HCV status than those who are anti-HCV-. Inaccurate knowledge is associated with different variables for anti-HCV+ vs. anti-HCV- individuals. There are opportunities to improve knowledge of HCV status and to therefore improve health outcomes and reduce transmission among this at-risk population.
2014 The Authors. ANZJPH 2014 Public Health Association of Australia.
DATE PUBLISHED
2014 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/06/01
revised 2013/07/01
accepted 2013/10/01
entrez 2014/04/03 06:00
pubmed 2014/04/03 06:00
medline 2015/11/13 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Shand FL Shand Fiona L FL Black Dog Institute, University of New South Wales.
Day C Day Carolyn C
Rawlinson W Rawlinson William W
Degenhardt L Degenhardt Louisa L
Martin NG Martin Nicholas G NG
Nelson EC Nelson Elliot C EC
INVESTIGATORS
JOURNAL
VOLUME: 38
ISSUE: 2
TITLE: Australian and New Zealand journal of public health
ISOABBREVIATION: Aust N Z J Public Health
YEAR: 2014
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1753-6405
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Aust N Z J Public Health
COUNTRY: Australia
ISSNLINKING: 1326-0200
NLMUNIQUEID: 9611095
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 DA017305 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
HCV
hepatitis C virus
injecting drug users
injecting risks
viral load
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Australia
Cross-Sectional Studies
Female
Health Knowledge, Attitudes, Practice
Hepacivirus
Hepatitis C etiology
Hepatitis C Antibodies etiology
Humans etiology
Logistic Models etiology
Male etiology
Middle Aged etiology
New South Wales epidemiology
Opiate Substitution Treatment epidemiology
Prevalence epidemiology
Retrospective Studies epidemiology
Reverse Transcriptase Polymerase Chain Reaction epidemiology
Risk Factors epidemiology
Substance Abuse, Intravenous epidemiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Hepatitis C Antibodies
OTHER ID's
OTHERID SOURCE
NIHMS709747 NLM
PMC4546838 NLM