Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24579201
TITLE
Genetic clustering on the hippocampal surface for genome-wide association studies.
ABSTRACT
Imaging genetics aims to discover how variants in the human genome influence brain measures derived from images. Genome-wide association scans (GWAS) can screen the genome for common differences in our DNA that relate to brain measures. In small samples, GWAS has low power as individual gene effects are weak and one must also correct for multiple comparisons across the genome and the image. Here we extend recent work on genetic clustering of images, to analyze surface-based models of anatomy using GWAS. We performed spherical harmonic analysis of hippocampal surfaces, automatically extracted from brain MRI scans of 1254 subjects. We clustered hippocampal surface regions with common genetic influences by examining genetic correlations (r(g)) between the normalized deformation values at all pairs of surface points. Using genetic correlations to cluster surface measures, we were able to boost effect sizes for genetic associations, compared to clustering with traditional phenotypic correlations using Pearson's r.
DATE PUBLISHED
2013
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2014/03/01 06:00
pubmed 2014/03/01 06:00
medline 2014/04/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hibar DP Hibar Derrek P DP Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA, USA.
Medland SE Medland Sarah E SE Queensland Institute of Medical Research, Brisbane, Australia.
Stein JL Stein Jason L JL Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA, USA.
Kim S Kim Sungeun S Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Shen L Shen Li L Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Saykin AJ Saykin Andrew J AJ Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
de Zubicaray GI de Zubicaray Greig I GI Functional Magnetic Resonance Imaging Laboratory, School of Psychology, University of Queensland, Brisbane, Australia.
McMahon KL McMahon Katie L KL Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.
Montgomery GW Montgomery Grant W GW Queensland Institute of Medical Research, Brisbane, Australia.
Martin NG Martin Nicholas G NG Queensland Institute of Medical Research, Brisbane, Australia.
Wright MJ Wright Margaret J MJ Queensland Institute of Medical Research, Brisbane, Australia.
Djurovic S Djurovic Srdjan S KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Agartz IA Agartz Ingrid A IA KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Andreassen OA Andreassen Ole A OA KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA, USA.
INVESTIGATORS
JOURNAL
VOLUME: 16
ISSUE: Pt 2
TITLE: Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
ISOABBREVIATION: Med Image Comput Comput Assist Interv
YEAR: 2013
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN:
ISSNTYPE:
MEDLINE JOURNAL
MEDLINETA: Med Image Comput Comput Assist Interv
COUNTRY: Germany
ISSNLINKING: 1433-7851
NLMUNIQUEID: 101249582
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 AG040060 NIA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Female
Genetic Predisposition to Disease genetics
Genome-Wide Association Study methods
Hippocampus physiopathology
Humans physiopathology
Image Interpretation, Computer-Assisted methods
Magnetic Resonance Imaging methods
Male methods
Mild Cognitive Impairment pathology
Multigene Family genetics
Reproducibility of Results genetics
Sensitivity and Specificity genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS576338 NLM
PMC4024454 NLM