Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24505811
TITLE
Exhaustive search of the SNP-sNP interactome identifies epistatic effects on brain volume in two cohorts.
ABSTRACT
The SNP-SNP interactome has rarely been explored in the context of neuroimaging genetics mainly due to the complexity of conducting approximately 10(11) pairwise statistical tests. However, recent advances in machine learning, specifically the iterative sure independence screening (SIS) method, have enabled the analysis of datasets where the number of predictors is much larger than the number of observations. Using an implementation of the SIS algorithm (called EPISIS), we used exhaustive search of the genome-wide, SNP-SNP interactome to identify and prioritize SNPs for interaction analysis. We identified a significant SNP pair, rs1345203 and rs1213205, associated with temporal lobe volume. We further examined the full-brain, voxelwise effects of the interaction in the ADNI dataset and separately in an independent dataset of healthy twins (QTIM). We found that each additional loading in the epistatic effect was associated with approximately 5% greater brain regional brain volume (a protective effect) in both the ADNI and QTIM samples.
DATE PUBLISHED
2013
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2014/02/08 06:00
pubmed 2014/02/08 06:00
medline 2014/02/28 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hibar DP Hibar Derrek P DP Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, USA.
Stein JL Stein Jason L JL Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, USA.
Jahanshad N Jahanshad Neda N Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, USA.
Kohannim O Kohannim Omid O Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, USA.
Toga AW Toga Arthur W AW Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, USA.
McMahon KL McMahon Katie L KL Center for Magnetic Resonance, School of Psychology, University of Queensland, Brisbane, Australia.
de Zubicaray GI de Zubicaray Greig I GI Functional Magnetic Resonance Imaging Laboratory, School of Psychology, University of Queensland, Brisbane, Australia.
Montgomery GW Montgomery Grant W GW Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.
Martin NG Martin Nicholas G NG Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.
Wright MJ Wright Margaret J MJ Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.
Weiner MW Weiner Michael W MW Department of Radiology, UC San Francisco, San Francisco, USA.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, USA.
INVESTIGATORS
JOURNAL
VOLUME: 16
ISSUE: Pt 3
TITLE: Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
ISOABBREVIATION: Med Image Comput Comput Assist Interv
YEAR: 2013
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN:
ISSNTYPE:
MEDLINE JOURNAL
MEDLINETA: Med Image Comput Comput Assist Interv
COUNTRY: Germany
ISSNLINKING: 1433-7851
NLMUNIQUEID: 101249582
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 MH097268 NIMH NIH HHS United States
U01 AG024904 NIA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Algorithms
Alzheimer Disease pathology
Brain pathology
Chromosome Mapping methods
Cohort Studies methods
Connectome methods
Epistasis, Genetic genetics
Genetic Predisposition to Disease genetics
Humans genetics
Magnetic Resonance Imaging methods
Organ Size methods
Polymorphism, Single Nucleotide genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS567610 NLM
PMC4109883 NLM