Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24311771
TITLE
Telomere length in circulating leukocytes is associated with lung function and disease.
ABSTRACT
Several clinical studies suggest the involvement of premature ageing processes in chronic obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied whether accelerated ageing indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the interindividual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15 846 controls defined according to the Global Lungs Initiative (GLI) criteria (or 1189 COPD cases according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria), 2834 asthma cases with 28 195 controls, and spirometric parameters (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC) of 12 595 individuals. Associations with telomere length were tested by linear regression, adjusting for age, sex and smoking status. We observed negative associations between telomere length and asthma (β= -0.0452, p=0.024) as well as COPD (β= -0.0982, p=0.001), with associations being stronger and more significant when using GLI criteria than those of GOLD. In both diseases, effects were stronger in females than males. The investigation of spirometric indices showed positive associations between telomere length and FEV1 (p=1.07×10(-7)), FVC (p=2.07×10(-5)), and FEV1/FVC (p=5.27×10(-3)). The effect was somewhat weaker in apparently healthy subjects than in COPD or asthma patients. Our results provide indirect evidence for the hypothesis that cellular senescence may contribute to the pathogenesis of COPD and asthma, and that lung function may reflect biological ageing primarily due to intrinsic processes, which are likely to be aggravated in lung diseases.
DATE PUBLISHED
2014 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2013/12/05
entrez 2013/12/07 06:00
pubmed 2013/12/07 06:00
medline 2015/01/31 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Albrecht E Albrecht Eva E For a list of the authors' affiliations see the Acknowledgements section.
Sillanpää E Sillanpää Elina E
Karrasch S Karrasch Stefan S
Alves AC Alves Alexessander Couto AC
Codd V Codd Veryan V
Hovatta I Hovatta Iiris I
Buxton JL Buxton Jessica L JL
Nelson CP Nelson Christopher P CP
Broer L Broer Linda L
Hägg S Hägg Sara S
Mangino M Mangino Massimo M
Willemsen G Willemsen Gonneke G
Surakka I Surakka Ida I
Ferreira MA Ferreira Manuel A R MA
Amin N Amin Najaf N
Oostra BA Oostra Ben A BA
Bäckmand HM Bäckmand Heli M HM
Peltonen M Peltonen Markku M
Sarna S Sarna Seppo S
Rantanen T Rantanen Taina T
Sipilä S Sipilä Sarianna S
Korhonen T Korhonen Tellervo T
Madden PA Madden Pamela A F PA
Gieger C Gieger Christian C
Jörres RA Jörres Rudolf A RA
Heinrich J Heinrich Joachim J
Behr J Behr Jürgen J
Huber RM Huber Rudolf M RM
Peters A Peters Annette A
Strauch K Strauch Konstantin K
Wichmann HE Wichmann H Erich HE
Waldenberger M Waldenberger Melanie M
Blakemore AI Blakemore Alexandra I F AI
de Geus EJ de Geus Eco J C EJ
Nyholt DR Nyholt Dale R DR
Henders AK Henders Anjali K AK
Piirilä PL Piirilä Päivi L PL
Rissanen A Rissanen Aila A
Magnusson PK Magnusson Patrik K E PK
Viñuela A Viñuela Ana A
Pietiläinen KH Pietiläinen Kirsi H KH
Martin NG Martin Nicholas G NG
Pedersen NL Pedersen Nancy L NL
Boomsma DI Boomsma Dorret I DI
Spector TD Spector Tim D TD
van Duijn CM van Duijn Cornelia M CM
Kaprio J Kaprio Jaakko J
Samani NJ Samani Nilesh J NJ
Jarvelin MR Jarvelin Marjo-Riitta MR
Schulz H Schulz Holger H
INVESTIGATORS
JOURNAL
VOLUME: 43
ISSUE: 4
TITLE: The European respiratory journal
ISOABBREVIATION: Eur. Respir. J.
YEAR: 2014
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1399-3003
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Eur Respir J
COUNTRY: England
ISSNLINKING: 0903-1936
NLMUNIQUEID: 8803460
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
MR/K014536/1 Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Aged
Asthma genetics
Case-Control Studies genetics
Cohort Studies genetics
Europe genetics
Female genetics
Forced Expiratory Volume genetics
Humans genetics
Leukocytes cytology
Lung Diseases genetics
Male genetics
Middle Aged genetics
Pulmonary Disease, Chronic Obstructive genetics
Regression Analysis genetics
Smoking genetics
Spirometry genetics
Telomere ultrastructure
Vital Capacity ultrastructure
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's