Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24299127
TITLE
The inheritance of extra-hepatic portosystemic shunts and elevated bile acid concentrations in Maltese dogs.
ABSTRACT
OBJECTIVES NlmCategory: OBJECTIVE
To determine the heritability of extra-hepatic portosystemic shunts and elevated post-prandial serum bile acid concentrations in Maltese dogs.
MATERIALS AND METHODS NlmCategory: METHODS
Maltese dogs were recruited and investigated by a variable combination of procedures including dynamic bile acid testing, rectal ammonia tolerance testing, ultrasonography, portal venography, surgical inspection or necropsy. In addition, nine test matings were carried out between affected and affected dogs, and affected and unaffected dogs.
RESULTS NlmCategory: RESULTS
In 135 variably related Maltese, shunt status could be confirmed in 113, including 19 with an extra-hepatic portosystemic shunt (17 confirmed at surgery, 2 at necropsy). Rectal ammonia tolerance testing results and post-prandial serum bile acid concentrations were retrievable for 50 and 88 dogs, respectively. Pedigree information was available for these 135 and an additional 164 related dogs. Two consecutive test matings were carried out between two affected animals (whose shunts had been attenuated), with 2 of 8 (25%) of offspring having an extra-hepatic portosystemic shunt. Six test matings were carried out between an affected and an unaffected animal, with 2 of 22 (9%) offspring affected. Heritability of extra-hepatic portosystemic shunt was 0·61 calculated using variance components analysis [95% confidence interval (CI) 0·14 to 1·0, P=0·001]. The best fitting model from segregation analysis was a common, partially penetrant, recessive model (allele frequency 0·34, penetrance 0·99, CI 0·09 to 1·0). The heritability of elevated post-prandial serum bile acid (and thus likely portal vein hypoplasia) was 0·81 (CI 0·43 to 1·0, P=0·2) after logarithmic transformation of post-prandial serum bile acid concentrations.
CLINICAL SIGNIFICANCE NlmCategory: CONCLUSIONS
There is strong support for extra-hepatic portosystemic shunts and elevated post-prandial serum bile acid concentrations both being inherited conditions in Maltese.
2013 British Small Animal Veterinary Association.
DATE PUBLISHED
2014 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2013/12/02
entrez 2013/12/05 06:00
pubmed 2013/12/05 06:00
medline 2014/09/27 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
O'Leary CA O'Leary C A CA School of Veterinary Science, The University of Queensland, Brisbane, 4072, Australia.
Parslow A Parslow A A
Malik R Malik R R
Hunt GB Hunt G B GB
Hurford RI Hurford R I RI
Tisdall PL Tisdall P L C PL
Duffy DL Duffy D L DL
INVESTIGATORS
JOURNAL
VOLUME: 55
ISSUE: 1
TITLE: The Journal of small animal practice
ISOABBREVIATION: J Small Anim Pract
YEAR: 2014
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1748-5827
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Small Anim Pract
COUNTRY: England
ISSNLINKING: 0022-4510
NLMUNIQUEID: 0165053
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Animals
Bile Acids and Salts blood
Dog Diseases genetics
Dogs genetics
Female genetics
Genetic Predisposition to Disease genetics
Male genetics
Pedigree genetics
Portal Vein abnormalities
Species Specificity abnormalities
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Bile Acids and Salts
OTHER ID's