Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24267761
TITLE
What can we learn from twin studies? A comprehensive evaluation of the equal environments assumption.
ABSTRACT
Twin studies are a major source of information about genetic effects on behavior, but they depend on a controversial assumption known as the equal environments assumption (EEA): that similarity in co-twins' environments is not predictive of similarity in co-twin outcomes. Although evidence has largely supported the EEA, critics have claimed that environmental similarity has not been measured well, and most studies of the EEA have focused on outcomes related to health and psychology. This article addresses these limitations through (1) a reanalysis of data from the most cited study of the EEA, Loehlin and Nichols (1976), using better measures, and through (2) an analysis of nationally representative twin data from MIDUS using more comprehensive controls on a wider variety of outcomes than previous studies. Results support a middle ground position; it is likely that the EEA is not strictly valid for most outcomes, but the resulting bias is likely modest.
Copyright 2013 Elsevier Inc. All rights reserved.
DATE PUBLISHED
2014 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/08/13
revised 2013/09/30
accepted 2013/10/11
entrez 2013/11/26 06:00
pubmed 2013/11/26 06:00
medline 2016/01/06 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Felson J Felson Jacob J William Paterson University, 300 Pompton Road, Wayne, NJ 07470, United States. Electronic address: felsonj@wpunj.edu.
INVESTIGATORS
JOURNAL
VOLUME: 43
ISSUE:
TITLE: Social science research
ISOABBREVIATION: Soc Sci Res
YEAR: 2014
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1096-0317
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Soc Sci Res
COUNTRY: United States
ISSNLINKING: 0049-089X
NLMUNIQUEID: 0330501
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Evaluation Study
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
P01 AG020166 NIA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Behavior genetics
Equal environments assumption
Twin studies
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Bias
Child
Diseases in Twins genetics
Environment genetics
Female genetics
Humans genetics
Male genetics
Middle Aged genetics
Neurotic Disorders genetics
Social Environment genetics
Twin Studies as Topic standards
Twins standards
United States standards
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's