Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24120074
TITLE
Parental separation and early substance involvement: results from children of alcoholic and cannabis dependent twins.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Risks associated with parental separation have received limited attention in research on children of parents with substance use disorders. We examined early substance involvement as a function of parental separation during childhood and parental alcohol and cannabis dependence.
METHOD NlmCategory: METHODS
Data were drawn from 1318 adolescent offspring of monozygotic (MZ) or dizygotic (DZ) Australian twin parents. Cox proportional hazards regression analyses were conducted predicting age at first use of alcohol, first alcohol intoxication, first use and first regular use of cigarettes, and first use of cannabis, from parental separation and both parent and cotwin substance dependence. Parent and cotwin alcohol and cannabis dependence were initially modeled separately, with post hoc tests for equality of effects.
RESULTS NlmCategory: RESULTS
With few exceptions, risks associated with parental alcohol versus cannabis dependence could be equated, with results largely suggestive of genetic transmission of risk from parental substance (alcohol or cannabis) dependence broadly defined. Controlling for parental substance dependence, parental separation was a strong predictor for all substance use variables, especially through age 13.
CONCLUSION NlmCategory: CONCLUSIONS
Together, findings underscore the importance of parental separation as a risk-factor for early substance involvement over and above both genetic and environmental influences specific to parental alcohol and cannabis dependence.
Copyright 2013 Elsevier Ireland Ltd. All rights reserved.
DATE PUBLISHED
2014 Jan 1
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/06/01
revised 2013/09/04
accepted 2013/09/10
aheadofprint 2013/09/19
entrez 2013/10/15 06:00
pubmed 2013/10/15 06:00
medline 2014/08/17 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Waldron M Waldron Mary M Department of Counseling and Educational Psychology, Indiana University School of Education, Bloomington, IN, United States; Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States. Electronic address: mwaldron@indiana.edu.
Grant JD Grant Julia D JD Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.
Bucholz KK Bucholz Kathleen K KK Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.
Lynskey MT Lynskey Michael T MT Addictions Department, Institute of Psychiatry, King's College, London, United Kingdom.
Slutske WS Slutske Wendy S WS Department of Psychology, University of Missouri, Columbia, MO, United States.
Glowinski AL Glowinski Anne L AL Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.
Henders A Henders Anjali A Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia.
Statham DJ Statham Dixie J DJ Faculty of Arts and Business, University of the Sunshine Coast, Queensland, Australia.
Martin NG Martin Nicholas G NG Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia.
Heath AC Heath Andrew C AC Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.
INVESTIGATORS
JOURNAL
VOLUME: 134
ISSUE:
TITLE: Drug and alcohol dependence
ISOABBREVIATION: Drug Alcohol Depend
YEAR: 2014
MONTH: Jan
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1879-0046
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Drug Alcohol Depend
COUNTRY: Ireland
ISSNLINKING: 0376-8716
NLMUNIQUEID: 7513587
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA010249 NIAAA NIH HHS United States
AA011998 NIAAA NIH HHS United States
AA015210 NIAAA NIH HHS United States
AA017688 NIAAA NIH HHS United States
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
DA023696 NIDA NIH HHS United States
DA14363 NIDA NIH HHS United States
K01 DA023696 NIDA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
P60 AA011998 NIAAA NIH HHS United States
R01 AA007535 NIAAA NIH HHS United States
R01 AA007728 NIAAA NIH HHS United States
R01 AA010249 NIAAA NIH HHS United States
R01 AA015210 NIAAA NIH HHS United States
R01 DA014363 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Adolescent substance use
Children of twins
Parental separation
Parental substance dependence
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Age Factors
Alcoholism psychology
Child psychology
Child of Impaired Parents psychology
Cohort Studies psychology
Divorce trends
Female trends
Humans trends
Male trends
Marijuana Abuse psychology
Risk Factors psychology
Twins psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS526041 NLM
PMC3908916 NLM