Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24097064
TITLE
Common variants associated with plasma triglycerides and risk for coronary artery disease.
ABSTRACT
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.
DATE PUBLISHED
2013 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/02/20
accepted 2013/09/13
aheadofprint 2013/10/06
entrez 2013/10/08 06:00
pubmed 2013/10/08 06:00
medline 2014/01/09 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Do R Do Ron R 1] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [3] Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. [4] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Willer CJ Willer Cristen J CJ
Schmidt EM Schmidt Ellen M EM
Sengupta S Sengupta Sebanti S
Gao C Gao Chi C
Peloso GM Peloso Gina M GM
Gustafsson S Gustafsson Stefan S
Kanoni S Kanoni Stavroula S
Ganna A Ganna Andrea A
Chen J Chen Jin J
Buchkovich ML Buchkovich Martin L ML
Mora S Mora Samia S
Beckmann JS Beckmann Jacques S JS
Bragg-Gresham JL Bragg-Gresham Jennifer L JL
Chang HY Chang Hsing-Yi HY
Demirkan A Demirkan Ayşe A
Den Hertog HM Den Hertog Heleen M HM
Donnelly LA Donnelly Louise A LA
Ehret GB Ehret Georg B GB
Esko T Esko Tõnu T
Feitosa MF Feitosa Mary F MF
Ferreira T Ferreira Teresa T
Fischer K Fischer Krista K
Fontanillas P Fontanillas Pierre P
Fraser RM Fraser Ross M RM
Freitag DF Freitag Daniel F DF
Gurdasani D Gurdasani Deepti D
Heikkilä K Heikkilä Kauko K
Hyppönen E Hyppönen Elina E
Isaacs A Isaacs Aaron A
Jackson AU Jackson Anne U AU
Johansson A Johansson Asa A
Johnson T Johnson Toby T
Kaakinen M Kaakinen Marika M
Kettunen J Kettunen Johannes J
Kleber ME Kleber Marcus E ME
Li X Li Xiaohui X
Luan J Luan Jian'an J
Lyytikäinen LP Lyytikäinen Leo-Pekka LP
Magnusson PK Magnusson Patrik K E PK
Mangino M Mangino Massimo M
Mihailov E Mihailov Evelin E
Montasser ME Montasser May E ME
Müller-Nurasyid M Müller-Nurasyid Martina M
Nolte IM Nolte Ilja M IM
O'Connell JR O'Connell Jeffrey R JR
Palmer CD Palmer Cameron D CD
Perola M Perola Markus M
Petersen AK Petersen Ann-Kristin AK
Sanna S Sanna Serena S
Saxena R Saxena Richa R
Service SK Service Susan K SK
Shah S Shah Sonia S
Shungin D Shungin Dmitry D
Sidore C Sidore Carlo C
Song C Song Ci C
Strawbridge RJ Strawbridge Rona J RJ
Surakka I Surakka Ida I
Tanaka T Tanaka Toshiko T
Teslovich TM Teslovich Tanya M TM
Thorleifsson G Thorleifsson Gudmar G
Van den Herik EG Van den Herik Evita G EG
Voight BF Voight Benjamin F BF
Volcik KA Volcik Kelly A KA
Waite LL Waite Lindsay L LL
Wong A Wong Andrew A
Wu Y Wu Ying Y
Zhang W Zhang Weihua W
Absher D Absher Devin D
Asiki G Asiki Gershim G
Barroso I Barroso Inês I
Been LF Been Latonya F LF
Bolton JL Bolton Jennifer L JL
Bonnycastle LL Bonnycastle Lori L LL
Brambilla P Brambilla Paolo P
Burnett MS Burnett Mary S MS
Cesana G Cesana Giancarlo G
Dimitriou M Dimitriou Maria M
Doney AS Doney Alex S F AS
Döring A Döring Angela A
Elliott P Elliott Paul P
Epstein SE Epstein Stephen E SE
Eyjolfsson GI Eyjolfsson Gudmundur Ingi GI
Gigante B Gigante Bruna B
Goodarzi MO Goodarzi Mark O MO
Grallert H Grallert Harald H
Gravito ML Gravito Martha L ML
Groves CJ Groves Christopher J CJ
Hallmans G Hallmans Göran G
Hartikainen AL Hartikainen Anna-Liisa AL
Hayward C Hayward Caroline C
Hernandez D Hernandez Dena D
Hicks AA Hicks Andrew A AA
Holm H Holm Hilma H
Hung YJ Hung Yi-Jen YJ
Illig T Illig Thomas T
Jones MR Jones Michelle R MR
Kaleebu P Kaleebu Pontiano P
Kastelein JJ Kastelein John J P JJ
Khaw KT Khaw Kay-Tee KT
Kim E Kim Eric E
Klopp N Klopp Norman N
Komulainen P Komulainen Pirjo P
Kumari M Kumari Meena M
Langenberg C Langenberg Claudia C
Lehtimäki T Lehtimäki Terho T
Lin SY Lin Shih-Yi SY
Lindström J Lindström Jaana J
Loos RJ Loos Ruth J F RJ
Mach F Mach François F
McArdle WL McArdle Wendy L WL
Meisinger C Meisinger Christa C
Mitchell BD Mitchell Braxton D BD
Müller G Müller Gabrielle G
Nagaraja R Nagaraja Ramaiah R
Narisu N Narisu Narisu N
Nieminen TV Nieminen Tuomo V M TV
Nsubuga RN Nsubuga Rebecca N RN
Olafsson I Olafsson Isleifur I
Ong KK Ong Ken K KK
Palotie A Palotie Aarno A
Papamarkou T Papamarkou Theodore T
Pomilla C Pomilla Cristina C
Pouta A Pouta Anneli A
Rader DJ Rader Daniel J DJ
Reilly MP Reilly Muredach P MP
Ridker PM Ridker Paul M PM
Rivadeneira F Rivadeneira Fernando F
Rudan I Rudan Igor I
Ruokonen A Ruokonen Aimo A
Samani N Samani Nilesh N
Scharnagl H Scharnagl Hubert H
Seeley J Seeley Janet J
Silander K Silander Kaisa K
Stančáková A Stančáková Alena A
Stirrups K Stirrups Kathleen K
Swift AJ Swift Amy J AJ
Tiret L Tiret Laurence L
Uitterlinden AG Uitterlinden Andre G AG
van Pelt LJ van Pelt L Joost LJ
Vedantam S Vedantam Sailaja S
Wainwright N Wainwright Nicholas N
Wijmenga C Wijmenga Cisca C
Wild SH Wild Sarah H SH
Willemsen G Willemsen Gonneke G
Wilsgaard T Wilsgaard Tom T
Wilson JF Wilson James F JF
Young EH Young Elizabeth H EH
Zhao JH Zhao Jing Hua JH
Adair LS Adair Linda S LS
Arveiler D Arveiler Dominique D
Assimes TL Assimes Themistocles L TL
Bandinelli S Bandinelli Stefania S
Bennett F Bennett Franklyn F
Bochud M Bochud Murielle M
Boehm BO Boehm Bernhard O BO
Boomsma DI Boomsma Dorret I DI
Borecki IB Borecki Ingrid B IB
Bornstein SR Bornstein Stefan R SR
Bovet P Bovet Pascal P
Burnier M Burnier Michel M
Campbell H Campbell Harry H
Chakravarti A Chakravarti Aravinda A
Chambers JC Chambers John C JC
Chen YD Chen Yii-Der Ida YD
Collins FS Collins Francis S FS
Cooper RS Cooper Richard S RS
Danesh J Danesh John J
Dedoussis G Dedoussis George G
de Faire U de Faire Ulf U
Feranil AB Feranil Alan B AB
Ferrières J Ferrières Jean J
Ferrucci L Ferrucci Luigi L
Freimer NB Freimer Nelson B NB
Gieger C Gieger Christian C
Groop LC Groop Leif C LC
Gudnason V Gudnason Vilmundur V
Gyllensten U Gyllensten Ulf U
Hamsten A Hamsten Anders A
Harris TB Harris Tamara B TB
Hingorani A Hingorani Aroon A
Hirschhorn JN Hirschhorn Joel N JN
Hofman A Hofman Albert A
Hovingh GK Hovingh G Kees GK
Hsiung CA Hsiung Chao Agnes CA
Humphries SE Humphries Steve E SE
Hunt SC Hunt Steven C SC
Hveem K Hveem Kristian K
Iribarren C Iribarren Carlos C
Järvelin MR Järvelin Marjo-Riitta MR
Jula A Jula Antti A
Kähönen M Kähönen Mika M
Kaprio J Kaprio Jaakko J
Kesäniemi A Kesäniemi Antero A
Kivimaki M Kivimaki Mika M
Kooner JS Kooner Jaspal S JS
Koudstaal PJ Koudstaal Peter J PJ
Krauss RM Krauss Ronald M RM
Kuh D Kuh Diana D
Kuusisto J Kuusisto Johanna J
Kyvik KO Kyvik Kirsten O KO
Laakso M Laakso Markku M
Lakka TA Lakka Timo A TA
Lind L Lind Lars L
Lindgren CM Lindgren Cecilia M CM
Martin NG Martin Nicholas G NG
März W März Winfried W
McCarthy MI McCarthy Mark I MI
McKenzie CA McKenzie Colin A CA
Meneton P Meneton Pierre P
Metspalu A Metspalu Andres A
Moilanen L Moilanen Leena L
Morris AD Morris Andrew D AD
Munroe PB Munroe Patricia B PB
Njølstad I Njølstad Inger I
Pedersen NL Pedersen Nancy L NL
Power C Power Chris C
Pramstaller PP Pramstaller Peter P PP
Price JF Price Jackie F JF
Psaty BM Psaty Bruce M BM
Quertermous T Quertermous Thomas T
Rauramaa R Rauramaa Rainer R
Saleheen D Saleheen Danish D
Salomaa V Salomaa Veikko V
Sanghera DK Sanghera Dharambir K DK
Saramies J Saramies Jouko J
Schwarz PE Schwarz Peter E H PE
Sheu WH Sheu Wayne H-H WH
Shuldiner AR Shuldiner Alan R AR
Siegbahn A Siegbahn Agneta A
Spector TD Spector Tim D TD
Stefansson K Stefansson Kari K
Strachan DP Strachan David P DP
Tayo BO Tayo Bamidele O BO
Tremoli E Tremoli Elena E
Tuomilehto J Tuomilehto Jaakko J
Uusitupa M Uusitupa Matti M
van Duijn CM van Duijn Cornelia M CM
Vollenweider P Vollenweider Peter P
Wallentin L Wallentin Lars L
Wareham NJ Wareham Nicholas J NJ
Whitfield JB Whitfield John B JB
Wolffenbuttel BH Wolffenbuttel Bruce H R BH
Altshuler D Altshuler David D
Ordovas JM Ordovas Jose M JM
Boerwinkle E Boerwinkle Eric E
Palmer CN Palmer Colin N A CN
Thorsteinsdottir U Thorsteinsdottir Unnur U
Chasman DI Chasman Daniel I DI
Rotter JI Rotter Jerome I JI
Franks PW Franks Paul W PW
Ripatti S Ripatti Samuli S
Cupples LA Cupples L Adrienne LA
Sandhu MS Sandhu Manjinder S MS
Rich SS Rich Stephen S SS
Boehnke M Boehnke Michael M
Deloukas P Deloukas Panos P
Mohlke KL Mohlke Karen L KL
Ingelsson E Ingelsson Erik E
Abecasis GR Abecasis Goncalo R GR
Daly MJ Daly Mark J MJ
Neale BM Neale Benjamin M BM
Kathiresan S Kathiresan Sekar S
INVESTIGATORS
JOURNAL
VOLUME: 45
ISSUE: 11
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2013
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
090532 Wellcome Trust United Kingdom
CZB/4/672 Chief Scientist Office United Kingdom
CZB/4/710 Chief Scientist Office United Kingdom
G0701863 Medical Research Council United Kingdom
G0901213 Medical Research Council United Kingdom
G1000143 Medical Research Council United Kingdom
MC_U106179471 Medical Research Council United Kingdom
MC_U106179472 Medical Research Council United Kingdom
MC_U106188470 Medical Research Council United Kingdom
MC_U123092720 Medical Research Council United Kingdom
MC_U950080926 Medical Research Council United Kingdom
MR/K013351/1 Medical Research Council United Kingdom
MR/K013491/1 Medical Research Council United Kingdom
MR/L003120/1 Medical Research Council United Kingdom
P30 DK063491 NIDDK NIH HHS United States
P60 DK020541 NIDDK NIH HHS United States
PG/08/094/26019 British Heart Foundation United Kingdom
R01 DK072193 NIDDK NIH HHS United States
R01 HL105756 NHLBI NIH HHS United States
R01 HL107816 NHLBI NIH HHS United States
R01 HL109946 NHLBI NIH HHS United States
R01HL107816 NHLBI NIH HHS United States
RG/08/014/24067 British Heart Foundation United Kingdom
T32HL007208 NHLBI NIH HHS United States
U01 HL069757 NHLBI NIH HHS United States
UL1 TR000124 NCATS NIH HHS United States
Canadian Institutes of Health Research Canada
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Biological Transport
Cholesterol, HDL genetics
Cholesterol, LDL genetics
Coronary Artery Disease genetics
Humans genetics
Polymorphism, Single Nucleotide genetics
Risk Factors genetics
Triglycerides metabolism
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Cholesterol, HDL
0 Cholesterol, LDL
0 Triglycerides
OTHER ID's
OTHERID SOURCE
NIHMS524704 NLM
PMC3904346 NLM