Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24065563
TITLE
Are bottom-up and top-down traits in dual-systems models of risky behavior genetically distinct?
ABSTRACT
Numerous dual-systems models of personality have been posited, which propose that behavior is influenced by two complementary systems. A bottom-up system is characterized by emotion-based drive (e.g., urge for rewarding experience), and a top-down system is characterized by the ability to control those urges. Although evidence suggests that these two systems are distinct and may be important in explaining some behaviors, these constructs are also moderately correlated. Notably, there has been little molecular or behavior genetic research on the genetic distinctness of the two systems central to the dual-systems model. The current study used a national twin sample to investigate the degree to which bottom-up and top-down systems, measured here as personality traits of sensation seeking and lack of planning, respectively, covary through genetic and environmental influences. Whereas the overlap between these systems was primarily comprised of unshared environmental influences (e.g., measurement error and unshared systematic variation) in females, a statistically significant proportion of the overlap was accounted for by genetic factors in men. Further, the genetic factors for these systems were moderately to highly correlated in men (rG = 0.62-0.79). These results provide clear support for a dual-systems model in women; however, these systems appear to share some common genetic influences in men.
DATE PUBLISHED
2013 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/05/17
accepted 2013/09/12
aheadofprint 2013/09/25
entrez 2013/09/26 06:00
pubmed 2013/09/26 06:00
medline 2014/06/12 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Ellingson JM Ellingson Jarrod M JM Department of Psychological Sciences, University of Missouri-Columbia, 210 McAlester Hall, Columbia, MO, 65211, USA, jarrod.ellingson@mail.missouri.edu.
Verges A Verges Alvaro A
Littlefield AK Littlefield Andrew K AK
Martin NG Martin Nicholas G NG
Slutske WS Slutske Wendy S WS
INVESTIGATORS
JOURNAL
VOLUME: 43
ISSUE: 6
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2013
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1573-3297
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
F31 AA019596 NIAAA NIH HHS United States
F31 AA022294 NIAAA NIH HHS United States
F31AA019596 NIAAA NIH HHS United States
F31AA022294 NIAAA NIH HHS United States
MH066206 NIMH NIH HHS United States
R01 MH066206 NIMH NIH HHS United States
T32AA13526 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Factor Analysis, Statistical
Female
Humans
Male
Models, Psychological
Personality genetics
Phenotype genetics
Risk-Taking genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS527425 NLM
PMC3929393 NLM