Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23992762
TITLE
Substance use and sexual intercourse onsets in adolescence: a genetically informative discordant twin design.
ABSTRACT
PURPOSE NlmCategory: OBJECTIVE
Using a genetically informed, discordant twin analysis, the objective of this study was to examine whether earlier onset of drinking and smoking behaviors predicted early sexual intercourse onset.
METHODS NlmCategory: METHODS
Over 3,400 adult same-sex twins from the Australian Twin Registry completed a structured interview that included retrospective reports on onsets of smoking, drinking, intoxication, and sexual intercourse and conduct disorder symptoms. A two-level frailty model estimated within-twin-pair and between-twin-pair comparisons. Onsets of smoking, drinking, drunkenness, and conduct disorder symptoms were estimated as sexual intercourse onset predictors.
RESULTS NlmCategory: RESULTS
After controlling for conduct disorder, smoking and drinking onset did not predict sexual intercourse onset for either within-twin-pair or between-twin-pair comparisons. Drunkenness onset had a significant effect on sexual intercourse onset, such that twins who first experienced alcohol intoxication at a younger age than their co-twins were also more likely to have sex earlier than their co-twins.
CONCLUSIONS NlmCategory: CONCLUSIONS
Relationships between substance use and sexual intercourse onsets may be due mostly to shared underlying factors; there was only a small relation between intoxication onset and sexual intercourse onset, and no direct relation between smoking and drinking onset and sexual intercourse onset.
Copyright 2014 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.
DATE PUBLISHED
2014 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/03/26
revised 2013/07/05
accepted 2013/07/11
aheadofprint 2013/08/29
entrez 2013/09/03 06:00
pubmed 2013/09/03 06:00
medline 2014/08/08 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Deutsch AR Deutsch Arielle R AR Department of Psychological Sciences, University of Missouri-Columbia, Columbia, Missouri; Midwest Alcohol Research Center, Columbia, Missouri. Electronic address: arielle.deutsch@gmail.com.
Slutske WS Slutske Wendy S WS Department of Psychological Sciences, University of Missouri-Columbia, Columbia, Missouri; Midwest Alcohol Research Center, Columbia, Missouri.
Heath AC Heath Andrew C AC Midwest Alcohol Research Center, Columbia, Missouri; Department of Psychiatry, Washington University, St. Louis, Missouri.
Madden PA Madden Pamela A F PA Midwest Alcohol Research Center, Columbia, Missouri; Department of Psychiatry, Washington University, St. Louis, Missouri.
Martin NG Martin Nicholas G NG Queensland Institute of Medical Research, Brisbane, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 54
ISSUE: 1
TITLE: The Journal of adolescent health : official publication of the Society for Adolescent Medicine
ISOABBREVIATION: J Adolesc Health
YEAR: 2014
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1879-1972
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Adolesc Health
COUNTRY: United States
ISSNLINKING: 1054-139X
NLMUNIQUEID: 9102136
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites J Adolesc Health. 2005 Jan;36(1):82-6 15661605
Cites Psychol Med. 2004 Nov;34(8):1519-30 15724882
Cites Psychol Methods. 2007 Jun;12(2):121-38 17563168
Cites Genes Brain Behav. 2009 Feb;8(1):107-13 19016887
Cites Behav Genet. 2010 Jan;40(1):12-21 19813084
Cites J Adolesc Health. 2010 Oct;47(4):389-98 20864009
Cites Arch Sex Behav. 2013 Jan;42(1):35-44 22441771
CommentIn J Adolesc Health. 2014 Jan;54(1):1-2 24360592
GRANTS
GRANTID AGENCY COUNTRY
K05 AA017688 NIAAA NIH HHS United States
R37 AA007728 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Problem behavior theory
Sexual intercourse onset
Substance use onset
Twin study
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age of Onset
Alcoholic Intoxication genetics
Coitus genetics
Female genetics
Humans genetics
Male genetics
Retrospective Studies genetics
Risk Factors genetics
Smoking genetics
Substance-Related Disorders genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS521675 NLM
PMC3872214 NLM