Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23836455
TITLE
Development of insula connectivity between ages 12 and 30 revealed by high angular resolution diffusion imaging.
ABSTRACT
The insula, hidden deep within the Sylvian fissures, has proven difficult to study from a connectivity perspective. Most of our current information on the anatomical connectivity of the insula comes from studies of nonhuman primates and post mortem human dissections. To date, only two neuroimaging studies have successfully examined the connectivity of the insula. Here we examine how the connectivity of the insula develops between ages 12 and 30, in 307 young adolescent and adult subjects scanned with 4-Tesla high angular resolution diffusion imaging (HARDI). The density of fiber connections between the insula and the frontal and parietal cortex decreased with age, but the connection density between the insula and the temporal cortex generally increased with age. This trajectory is in line with well-known patterns of cortical development in these regions. In addition, males and females showed different developmental trajectories for the connection between the left insula and the left precentral gyrus. The insula plays many different roles, some of them affected in neuropsychiatric disorders; this information on the insula's connectivity may help efforts to elucidate mechanisms of brain disorders in which it is implicated.
Copyright 2013 Wiley Periodicals, Inc.
DATE PUBLISHED
2014 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/11/27
revised 2013/02/05
accepted 2013/03/04
aheadofprint 2013/07/08
entrez 2013/07/10 06:00
pubmed 2013/07/10 06:00
medline 2014/12/15 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Dennis EL Dennis Emily L EL Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, California.
Jahanshad N Jahanshad Neda N
McMahon KL McMahon Katie L KL
de Zubicaray GI de Zubicaray Greig I GI
Martin NG Martin Nicholas G NG
Hickie IB Hickie Ian B IB
Toga AW Toga Arthur W AW
Wright MJ Wright Margaret J MJ
Thompson PM Thompson Paul M PM
INVESTIGATORS
JOURNAL
VOLUME: 35
ISSUE: 4
TITLE: Human brain mapping
ISOABBREVIATION: Hum Brain Mapp
YEAR: 2014
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1097-0193
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Hum Brain Mapp
COUNTRY: United States
ISSNLINKING: 1065-9471
NLMUNIQUEID: 9419065
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
EB007813 NIBIB NIH HHS United States
EB008281 NIBIB NIH HHS United States
EB008432 NIBIB NIH HHS United States
P41 RR013642 NCRR NIH HHS United States
P41 RR013642 NCRR NIH HHS United States
R01 EB007813 NIBIB NIH HHS United States
R01 EB008281 NIBIB NIH HHS United States
R01 EB008432 NIBIB NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
T32 MH073526 NIMH NIH HHS United States
T32MH073526-06 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
HARDI
development
insula
structural connectivity
tractography
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adolescent Development
Adult
Cerebral Cortex growth & development
Child growth & development
Diffusion Tensor Imaging growth & development
Female growth & development
Frontal Lobe growth & development
Functional Laterality growth & development
Humans growth & development
Image Processing, Computer-Assisted growth & development
Male growth & development
Neural Pathways growth & development
Parietal Lobe growth & development
Sex Factors growth & development
Temporal Lobe growth & development
Young Adult growth & development
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS575973 NLM
PMC4017914 NLM