Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23817571
TITLE
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
ABSTRACT
Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.
DATE PUBLISHED
2013 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/10/29
accepted 2013/06/10
aheadofprint 2013/06/30
entrez 2013/07/03 06:00
pubmed 2013/07/03 06:00
medline 2013/10/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Bønnelykke K Bønnelykke Klaus K COPSAC (Copenhagen Prospective Studies on Asthma in Childhood), Health Sciences, University of Copenhagen & Copenhagen University Hospital, Gentofte, Denmark. kb@copsac.com
Matheson MC Matheson Melanie C MC
Pers TH Pers Tune H TH
Granell R Granell Raquel R
Strachan DP Strachan David P DP
Alves AC Alves Alexessander Couto AC
Linneberg A Linneberg Allan A
Curtin JA Curtin John A JA
Warrington NM Warrington Nicole M NM
Standl M Standl Marie M
Kerkhof M Kerkhof Marjan M
Jonsdottir I Jonsdottir Ingileif I
Bukvic BK Bukvic Blazenka K BK
Kaakinen M Kaakinen Marika M
Sleimann P Sleimann Patrick P
Thorleifsson G Thorleifsson Gudmar G
Thorsteinsdottir U Thorsteinsdottir Unnur U
Schramm K Schramm Katharina K
Baltic S Baltic Svetlana S
Kreiner-Møller E Kreiner-Møller Eskil E
Simpson A Simpson Angela A
St Pourcain B St Pourcain Beate B
Coin L Coin Lachlan L
Hui J Hui Jennie J
Walters EH Walters Eugene H EH
Tiesler CM Tiesler Carla M T CM
Duffy DL Duffy David L DL
Jones G Jones Graham G
Ring SM Ring Susan M SM
McArdle WL McArdle Wendy L WL
Price L Price Loren L
Robertson CF Robertson Colin F CF
Pekkanen J Pekkanen Juha J
Tang CS Tang Clara S CS
Thiering E Thiering Elisabeth E
Montgomery GW Montgomery Grant W GW
Hartikainen AL Hartikainen Anna-Liisa AL
Dharmage SC Dharmage Shyamali C SC
Husemoen LL Husemoen Lise L LL
Herder C Herder Christian C
Kemp JP Kemp John P JP
Elliot P Elliot Paul P
James A James Alan A
Waldenberger M Waldenberger Melanie M
Abramson MJ Abramson Michael J MJ
Fairfax BP Fairfax Benjamin P BP
Knight JC Knight Julian C JC
Gupta R Gupta Ramneek R
Thompson PJ Thompson Philip J PJ
Holt P Holt Patrick P
Sly P Sly Peter P
Hirschhorn JN Hirschhorn Joel N JN
Blekic M Blekic Mario M
Weidinger S Weidinger Stephan S
Hakonarsson H Hakonarsson Hakon H
Stefansson K Stefansson Kari K
Heinrich J Heinrich Joachim J
Postma DS Postma Dirkje S DS
Custovic A Custovic Adnan A
Pennell CE Pennell Craig E CE
Jarvelin MR Jarvelin Marjo-Riitta MR
Koppelman GH Koppelman Gerard H GH
Timpson N Timpson Nicholas N
Ferreira MA Ferreira Manuel A MA
Bisgaard H Bisgaard Hans H
Henderson AJ Henderson A John AJ
Australian Asthma Genetics Consortium (AAGC)
EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Henderson A John AJ
JOURNAL
VOLUME: 45
ISSUE: 8
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2013
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
090532 Wellcome Trust United Kingdom
092731 Wellcome Trust United Kingdom
G0601361 Medical Research Council United Kingdom
G0801056 Medical Research Council United Kingdom
G9815508 Medical Research Council United Kingdom
MC_PC_15018 Medical Research Council United Kingdom
MC_UU_12013/3 Medical Research Council United Kingdom
MR/K002449/1 Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Alleles
Computational Biology
Gene Regulatory Networks
Genetic Loci
Genome-Wide Association Study
Genomics
Humans
Hypersensitivity metabolism
Phenotype metabolism
Polymorphism, Single Nucleotide metabolism
Quantitative Trait Loci metabolism
Signal Transduction metabolism
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's