Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23568457
TITLE
Genetic variants associated with disordered eating.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
Although the genetic contribution to the development of anorexia nervosa (AN) has long been recognized, there has been little progress relative to other psychiatric disorders in identifying specific susceptibility genes. Here, we have carried out a genome-wide association study on an unselected community sample of female twins surveyed for eating disorders.
METHOD NlmCategory: METHODS
We conducted genome-wide association analyses in 2,564 female twins for four different phenotypes derived from self-report data relating to lifetime presence of 15 types of disordered eating: AN spectrum, bulimia nervosa (BN) spectrum, purging via substances, and a binary measure of no disordered eating behaviors versus three or more. To complement the variant level results, we also conducted gene-based association tests using VEGAS software.
RESULTS NlmCategory: RESULTS
Although no variants reached genome-wide significance at the level of p < 10(-8), six regions were suggestive (p < 5 × 10(-7)). The current results implicate the following genes: CLEC5A, LOC136242, TSHZ1, and SYTL5 for the AN spectrum phenotype; NT5C1B for the BN spectrum phenotype; and ATP8A2 for the disordered eating behaviors phenotype.
DISCUSSION NlmCategory: CONCLUSIONS
As with other medical and psychiatric phenotypes, much larger samples and meta-analyses will ultimately be needed to identify genes and pathways contributing to predisposition to eating disorders.
2013 Wiley Periodicals, Inc.
DATE PUBLISHED
2013 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
accepted 2013/02/04
aheadofprint 2013/04/09
entrez 2013/04/10 06:00
pubmed 2013/04/10 06:00
medline 2014/02/28 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Wade TD Wade Tracey D TD School of Psychology, Flinders University, Adelaide, South Australia, Australia.
Gordon S Gordon Scott S
Medland S Medland Sarah S
Bulik CM Bulik Cynthia M CM
Heath AC Heath Andrew C AC
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 46
ISSUE: 6
TITLE: The International journal of eating disorders
ISOABBREVIATION: Int J Eat Disord
YEAR: 2013
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1098-108X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Int J Eat Disord
COUNTRY: United States
ISSNLINKING: 0276-3478
NLMUNIQUEID: 8111226
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA14041 NIAAA NIH HHS United States
AA17688 NIAAA NIH HHS United States
DA012854 NIDA NIH HHS United States
DA019951 NIDA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
R01 AA013320 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
anorexia nervosa
genes
genome-wide association study
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Feeding and Eating Disorders genetics
Female genetics
Genome-Wide Association Study genetics
Genotype genetics
Humans genetics
Phenotype genetics
Surveys and Questionnaires genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS470177 NLM
PMC3775874 NLM