Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23321625
TITLE
Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect.
ABSTRACT
Telomere length (TL) has been associated with aging and mortality, but individual differences are also influenced by genetic factors, with previous studies reporting heritability estimates ranging from 34 to 82%. Here we investigate the heritability, mode of inheritance and the influence of parental age at birth on TL in six large, independent cohort studies with a total of 19,713 participants. The meta-analysis estimate of TL heritability was 0.70 (95% CI 0.64-0.76) and is based on a pattern of results that is highly similar for twins and other family members. We observed a stronger mother-offspring (r=0.42; P-value=3.60 × 10(-61)) than father-offspring correlation (r=0.33; P-value=7.01 × 10(-5)), and a significant positive association with paternal age at offspring birth (β=0.005; P-value=7.01 × 10(-5)). Interestingly, a significant and quite substantial correlation in TL between spouses (r=0.25; P-value=2.82 × 10(-30)) was seen, which appeared stronger in older spouse pairs (mean age ≥55 years; r=0.31; P-value=4.27 × 10(-23)) than in younger pairs (mean age<55 years; r=0.20; P-value=3.24 × 10(-10)). In summary, we find a high and very consistent heritability estimate for TL, evidence for a maternal inheritance component and a positive association with paternal age.
DATE PUBLISHED
2013 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/09/04
revised 2012/11/08
accepted 2012/11/13
aheadofprint 2013/01/16
entrez 2013/01/17 06:00
pubmed 2013/01/17 06:00
medline 2014/05/03 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Broer L Broer Linda L 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands [2] Netherlands Consortium for Healthy Aging, Leiden University Medical Center, Leiden, The Netherlands.
Codd V Codd Veryan V
Nyholt DR Nyholt Dale R DR
Deelen J Deelen Joris J
Mangino M Mangino Massimo M
Willemsen G Willemsen Gonneke G
Albrecht E Albrecht Eva E
Amin N Amin Najaf N
Beekman M Beekman Marian M
de Geus EJ de Geus Eco J C EJ
Henders A Henders Anjali A
Nelson CP Nelson Christopher P CP
Steves CJ Steves Claire J CJ
Wright MJ Wright Margie J MJ
de Craen AJ de Craen Anton J M AJ
Isaacs A Isaacs Aaron A
Matthews M Matthews Mary M
Moayyeri A Moayyeri Alireza A
Montgomery GW Montgomery Grant W GW
Oostra BA Oostra Ben A BA
Vink JM Vink Jacqueline M JM
Spector TD Spector Tim D TD
Slagboom PE Slagboom P Eline PE
Martin NG Martin Nicholas G NG
Samani NJ Samani Nilesh J NJ
van Duijn CM van Duijn Cornelia M CM
Boomsma DI Boomsma Dorret I DI
INVESTIGATORS
JOURNAL
VOLUME: 21
ISSUE: 10
TITLE: European journal of human genetics : EJHG
ISOABBREVIATION: Eur. J. Hum. Genet.
YEAR: 2013
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5438
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Eur J Hum Genet
COUNTRY: England
ISSNLINKING: 1018-4813
NLMUNIQUEID: 9302235
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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CommentIn Eur J Hum Genet. 2014 Jan;22(1):8-9 24022299
CommentIn Eur J Hum Genet. 2015 Jan;23(1):3-4 24755952
CommentIn Eur J Hum Genet. 2014 Jan;22(1):10-1 24149546
GRANTS
GRANTID AGENCY COUNTRY
British Heart Foundation United Kingdom
Department of Health United Kingdom
Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Case-Control Studies
Female
Humans
Inheritance Patterns
Male
Middle Aged
Paternal Age
Pedigree
Telomere genetics
Telomere Shortening genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3778341 NLM