Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23031429
TITLE
A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.
ABSTRACT
Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors(P=3.98 x 10-8). We followed up the association in further genotyped monozygotic twins (N= 1,261),which showed a moderate association for the variant (P= 0.200, same direction of an effect). In addition,we report a new association on the level of apolipoprotein A-ll (P= 4.03 x 1 o-8).
DATE PUBLISHED
2012 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2012/10/03
entrez 2012/10/04 06:00
pubmed 2012/10/04 06:00
medline 2013/02/16 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Surakka I Surakka Ida I Institute for Molecular Medicine, University of Helsinki, Finland.
Whitfield JB Whitfield John B JB
Perola M Perola Markus M
Visscher PM Visscher Peter M PM
Montgomery GW Montgomery Grant W GW
Falchi M Falchi Mario M
Willemsen G Willemsen Gonneke G
de Geus EJ de Geus Eco J C EJ
Magnusson PK Magnusson Patrik K E PK
Christensen K Christensen Kaare K
Sørensen TI Sørensen Thorkild I A TI
Pietiläinen KH Pietiläinen Kirsi H KH
Rantanen T Rantanen Taina T
Silander K Silander Kaisa K
Widén E Widén Elisabeth E
Muilu J Muilu Juha J
Rahman I Rahman Iffat I
Liljedahl U Liljedahl Ulrika U
Syvänen AC Syvänen Ann-Christine AC
Palotie A Palotie Aarno A
Kaprio J Kaprio Jaakko J
Kyvik KO Kyvik Kirsten O KO
Pedersen NL Pedersen Nancy L NL
Boomsma DI Boomsma Dorret I DI
Spector T Spector Tim T
Martin NG Martin Nicholas G NG
Ripatti S Ripatti Samuli S
Peltonen L Peltonen Leena L
GenomEUtwin Project
INVESTIGATORS
JOURNAL
VOLUME: 15
ISSUE: 6
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2012
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Clinical Trial
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
079771 Wellcome Trust United Kingdom
098051 Wellcome Trust United Kingdom
AA07535 NIAAA NIH HHS United States
AA10248 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
AA14041 NIAAA NIH HHS United States
AA17688 NIAAA NIH HHS United States
AG028555 NIA NIH HHS United States
AG04563 NIA NIH HHS United States
AG08724 NIA NIH HHS United States
AG08861 NIA NIH HHS United States
AG10175 NIA NIH HHS United States
DA12854 NIDA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
MH66206 NIMH NIH HHS United States
Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Aged, 80 and over
Alleles
Apolipoprotein A-II genetics
Cholesterol, HDL genetics
Female genetics
GTPase-Activating Proteins metabolism
Gene-Environment Interaction metabolism
Genetic Loci metabolism
Genome-Wide Association Study metabolism
Humans metabolism
Introns metabolism
Middle Aged metabolism
Polymorphism, Single Nucleotide metabolism
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Apolipoprotein A-II
0 Cholesterol, HDL
0 GTPase-Activating Proteins
0 SRGAP2 protein, human
OTHER ID's
OTHERID SOURCE
EMS62065 NLM
PMC4333218 NLM