Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
22847273
TITLE
The continuing value of twin studies in the omics era.
ABSTRACT
The classical twin study has been a powerful heuristic in biomedical, psychiatric and behavioural research for decades. Twin registries worldwide have collected biological material and longitudinal phenotypic data on tens of thousands of twins, providing a valuable resource for studying complex phenotypes and their underlying biology. In this Review, we consider the continuing value of twin studies in the current era of molecular genetic studies. We conclude that classical twin methods combined with novel technologies represent a powerful approach towards identifying and understanding the molecular pathways that underlie complex traits.
DATE PUBLISHED
2012 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2012/07/31
entrez 2012/08/01 06:00
pubmed 2012/08/01 06:00
medline 2012/11/06 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
van Dongen J van Dongen Jenny J Biological Psychology, VU University, Van der Boechorststraat 1, 1081BT, Amsterdam, The Netherlands.
Slagboom PE Slagboom P Eline PE
Draisma HH Draisma Harmen H M HH
Martin NG Martin Nicholas G NG
Boomsma DI Boomsma Dorret I DI
INVESTIGATORS
JOURNAL
VOLUME: 13
ISSUE: 9
TITLE: Nature reviews. Genetics
ISOABBREVIATION: Nat. Rev. Genet.
YEAR: 2012
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN:
ISSNTYPE:
MEDLINE JOURNAL
MEDLINETA: Nat Rev Genet
COUNTRY: England
ISSNLINKING: 1471-0056
NLMUNIQUEID: 100962779
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Review
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Epigenomics
Female
Genetic Diseases, Inborn genetics
Genomics genetics
Humans genetics
Longitudinal Studies genetics
Male genetics
Metabolomics genetics
Proteomics genetics
Registries genetics
Twin Studies as Topic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's