Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22806211
TITLE
The genetics of addiction-a translational perspective.
ABSTRACT
Addictions are serious and common psychiatric disorders, and are among the leading contributors to preventable death. This selective review outlines and highlights the need for a multi-method translational approach to genetic studies of these important conditions, including both licit (alcohol, nicotine) and illicit (cannabis, cocaine, opiates) drug addictions and the behavioral addiction of disordered gambling. First, we review existing knowledge from twin studies that indicates both the substantial heritability of substance-specific addictions and the genetic overlap across addiction to different substances. Next, we discuss the limited number of candidate genes which have shown consistent replication, and the implications of emerging genomewide association findings for the genetic architecture of addictions. Finally, we review the utility of extensions to existing methods such as novel phenotyping, including the use of endophenotypes, biomarkers and neuroimaging outcomes; emerging methods for identifying alternative sources of genetic variation and accompanying statistical methodologies to interpret them; the role of gene-environment interplay; and importantly, the potential role of genetic variation in suggesting new alternatives for treatment of addictions.
DATE PUBLISHED
2012
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2012/07/19 06:00
pubmed 2012/07/19 06:00
medline 2013/03/15 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Agrawal A Agrawal A A Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO 63110, USA. arpana@wustl.edu
Verweij KJ Verweij K J H KJ
Gillespie NA Gillespie N A NA
Heath AC Heath A C AC
Lessov-Schlaggar CN Lessov-Schlaggar C N CN
Martin NG Martin N G NG
Nelson EC Nelson E C EC
Slutske WS Slutske W S WS
Whitfield JB Whitfield J B JB
Lynskey MT Lynskey M T MT
INVESTIGATORS
JOURNAL
VOLUME: 2
ISSUE:
TITLE: Translational psychiatry
ISOABBREVIATION: Transl Psychiatry
YEAR: 2012
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2158-3188
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Transl Psychiatry
COUNTRY: United States
ISSNLINKING: 2158-3188
NLMUNIQUEID: 101562664
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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ErratumIn Transl Psychiatry. 2012;2:e193 3669669
GRANTS
GRANTID AGENCY COUNTRY
AA013326 NIAAA NIH HHS United States
AA014041 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA17688 NIAAA NIH HHS United States
DA027046 NIDA NIH HHS United States
DA030976 NIDA NIH HHS United States
DA17305 NIDA NIH HHS United States
DA18660 NIDA NIH HHS United States
DA23668 NIDA NIH HHS United States
DA25886 NIDA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
R00DA023549 NIDA NIH HHS United States
R01 AA017915 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Biological Markers
Diagnostic and Statistical Manual of Mental Disorders
Endophenotypes
Gene-Environment Interaction
Genetic Association Studies
Genetic Predisposition to Disease
Genetic Variation
Humans
Pharmacogenetics
Substance-Related Disorders genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Biological Markers
OTHER ID's
OTHERID SOURCE
PMC3410620 NLM