Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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22479202
TITLE
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
ABSTRACT
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3×10(-4)). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3×10(-3), n = 22,044), increased triglycerides (p = 2.6×10(-14), n = 93,440), increased waist-to-hip ratio (p = 1.8×10(-5), n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4×10(-3), n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL-cholesterol concentrations (p = 4.5×10(-13), n = 96,748) and decreased BMI (p = 1.4×10(-4), n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance.
DATE PUBLISHED
2012
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2011/09/30
accepted 2012/02/03
epublish 2012/03/29
entrez 2012/04/06 06:00
pubmed 2012/04/06 06:00
medline 2012/09/05 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Dastani Z Dastani Zari Z Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada.
Hivert MF Hivert Marie-France MF
Timpson N Timpson Nicholas N
Perry JR Perry John R B JR
Yuan X Yuan Xin X
Scott RA Scott Robert A RA
Henneman P Henneman Peter P
Heid IM Heid Iris M IM
Kizer JR Kizer Jorge R JR
Lyytikäinen LP Lyytikäinen Leo-Pekka LP
Fuchsberger C Fuchsberger Christian C
Tanaka T Tanaka Toshiko T
Morris AP Morris Andrew P AP
Small K Small Kerrin K
Isaacs A Isaacs Aaron A
Beekman M Beekman Marian M
Coassin S Coassin Stefan S
Lohman K Lohman Kurt K
Qi L Qi Lu L
Kanoni S Kanoni Stavroula S
Pankow JS Pankow James S JS
Uh HW Uh Hae-Won HW
Wu Y Wu Ying Y
Bidulescu A Bidulescu Aurelian A
Rasmussen-Torvik LJ Rasmussen-Torvik Laura J LJ
Greenwood CM Greenwood Celia M T CM
Ladouceur M Ladouceur Martin M
Grimsby J Grimsby Jonna J
Manning AK Manning Alisa K AK
Liu CT Liu Ching-Ti CT
Kooner J Kooner Jaspal J
Mooser VE Mooser Vincent E VE
Vollenweider P Vollenweider Peter P
Kapur KA Kapur Karen A KA
Chambers J Chambers John J
Wareham NJ Wareham Nicholas J NJ
Langenberg C Langenberg Claudia C
Frants R Frants Rune R
Willems-Vandijk K Willems-Vandijk Ko K
Oostra BA Oostra Ben A BA
Willems SM Willems Sara M SM
Lamina C Lamina Claudia C
Winkler TW Winkler Thomas W TW
Psaty BM Psaty Bruce M BM
Tracy RP Tracy Russell P RP
Brody J Brody Jennifer J
Chen I Chen Ida I
Viikari J Viikari Jorma J
Kähönen M Kähönen Mika M
Pramstaller PP Pramstaller Peter P PP
Evans DM Evans David M DM
St Pourcain B St Pourcain Beate B
Sattar N Sattar Naveed N
Wood AR Wood Andrew R AR
Bandinelli S Bandinelli Stefania S
Carlson OD Carlson Olga D OD
Egan JM Egan Josephine M JM
Böhringer S Böhringer Stefan S
van Heemst D van Heemst Diana D
Kedenko L Kedenko Lyudmyla L
Kristiansson K Kristiansson Kati K
Nuotio ML Nuotio Marja-Liisa ML
Loo BM Loo Britt-Marie BM
Harris T Harris Tamara T
Garcia M Garcia Melissa M
Kanaya A Kanaya Alka A
Haun M Haun Margot M
Klopp N Klopp Norman N
Wichmann HE Wichmann H-Erich HE
Deloukas P Deloukas Panos P
Katsareli E Katsareli Efi E
Couper DJ Couper David J DJ
Duncan BB Duncan Bruce B BB
Kloppenburg M Kloppenburg Margreet M
Adair LS Adair Linda S LS
Borja JB Borja Judith B JB
DIAGRAM+ Consortium
MAGIC Consortium
GLGC Investigators
MuTHER Consortium
Wilson JG Wilson James G JG
Musani S Musani Solomon S
Guo X Guo Xiuqing X
Johnson T Johnson Toby T
Semple R Semple Robert R
Teslovich TM Teslovich Tanya M TM
Allison MA Allison Matthew A MA
Redline S Redline Susan S
Buxbaum SG Buxbaum Sarah G SG
Mohlke KL Mohlke Karen L KL
Meulenbelt I Meulenbelt Ingrid I
Ballantyne CM Ballantyne Christie M CM
Dedoussis GV Dedoussis George V GV
Hu FB Hu Frank B FB
Liu Y Liu Yongmei Y
Paulweber B Paulweber Bernhard B
Spector TD Spector Timothy D TD
Slagboom PE Slagboom P Eline PE
Ferrucci L Ferrucci Luigi L
Jula A Jula Antti A
Perola M Perola Markus M
Raitakari O Raitakari Olli O
Florez JC Florez Jose C JC
Salomaa V Salomaa Veikko V
Eriksson JG Eriksson Johan G JG
Frayling TM Frayling Timothy M TM
Hicks AA Hicks Andrew A AA
Lehtimäki T Lehtimäki Terho T
Smith GD Smith George Davey GD
Siscovick DS Siscovick David S DS
Kronenberg F Kronenberg Florian F
van Duijn C van Duijn Cornelia C
Loos RJ Loos Ruth J F RJ
Waterworth DM Waterworth Dawn M DM
Meigs JB Meigs James B JB
Dupuis J Dupuis Josee J
Richards JB Richards J Brent JB
Voight BF Voight Benjamin F BF
Scott LJ Scott Laura J LJ
Steinthorsdottir V Steinthorsdottir Valgerdur V
Dina C Dina Christian C
Welch RP Welch Ryan P RP
Zeggini E Zeggini Eleftheria E
Huth C Huth Cornelia C
Aulchenko YS Aulchenko Yurii S YS
Thorleifsson G Thorleifsson Gudmar G
McCulloch LJ McCulloch Laura J LJ
Ferreira T Ferreira Teresa T
Grallert H Grallert Harald H
Amin N Amin Najaf N
Wu G Wu Guanming G
Willer CJ Willer Cristen J CJ
Raychaudhuri S Raychaudhuri Soumya S
McCarroll SA McCarroll Steve A SA
Hofmann OM Hofmann Oliver M OM
Segrè AV Segrè Ayellet V AV
van Hoek M van Hoek Mandy M
Navarro P Navarro Pau P
Ardlie K Ardlie Kristin K
Balkau B Balkau Beverley B
Benediktsson R Benediktsson Rafn R
Bennett AJ Bennett Amanda J AJ
Blagieva R Blagieva Roza R
Boerwinkle E Boerwinkle Eric E
Bonnycastle LL Bonnycastle Lori L LL
Boström KB Boström Kristina Bengtsson KB
Bravenboer B Bravenboer Bert B
Bumpstead S Bumpstead Suzannah S
Burtt NP Burtt Noël P NP
Charpentier G Charpentier Guillaume G
Chines PS Chines Peter S PS
Cornelis M Cornelis Marilyn M
Crawford G Crawford Gabe G
Doney AS Doney Alex S F AS
Elliott KS Elliott Katherine S KS
Elliott AL Elliott Amanda L AL
Erdos MR Erdos Michael R MR
Fox CS Fox Caroline S CS
Franklin CS Franklin Christopher S CS
Ganser M Ganser Martha M
Gieger C Gieger Christian C
Grarup N Grarup Niels N
Green T Green Todd T
Griffin S Griffin Simon S
Groves CJ Groves Christopher J CJ
Guiducci C Guiducci Candace C
Hadjadj S Hadjadj Samy S
Hassanali N Hassanali Neelam N
Herder C Herder Christian C
Isomaa B Isomaa Bo B
Jackson AU Jackson Anne U AU
Johnson PR Johnson Paul R V PR
Jørgensen T Jørgensen Torben T
Kao WH Kao Wen H L WH
Kong A Kong Augustine A
Kraft P Kraft Peter P
Kuusisto J Kuusisto Johanna J
Lauritzen T Lauritzen Torsten T
Li M Li Man M
Lieverse A Lieverse Aloysius A
Lindgren CM Lindgren Cecilia M CM
Lyssenko V Lyssenko Valeriya V
Marre M Marre Michel M
Meitinger T Meitinger Thomas T
Midthjell K Midthjell Kristian K
Morken MA Morken Mario A MA
Narisu N Narisu Narisu N
Nilsson P Nilsson Peter P
Owen KR Owen Katharine R KR
Payne F Payne Felicity F
Petersen AK Petersen Ann-Kristin AK
Platou C Platou Carl C
Proença C Proença Christine C
Prokopenko I Prokopenko Inga I
Rathmann W Rathmann Wolfgang W
Rayner NW Rayner N William NW
Robertson NR Robertson Neil R NR
Rocheleau G Rocheleau Ghislain G
Roden M Roden Michael M
Sampson MJ Sampson Michael J MJ
Saxena R Saxena Richa R
Shields BM Shields Beverley M BM
Shrader P Shrader Peter P
Sigurdsson G Sigurdsson Gunnar G
Sparsø T Sparsø Thomas T
Strassburger K Strassburger Klaus K
Stringham HM Stringham Heather M HM
Sun Q Sun Qi Q
Swift AJ Swift Amy J AJ
Thorand B Thorand Barbara B
Tichet J Tichet Jean J
Tuomi T Tuomi Tiinamaija T
van Dam RM van Dam Rob M RM
van Haeften TW van Haeften Timon W TW
van Herpt T van Herpt Thijs T
van Vliet-Ostaptchouk JV van Vliet-Ostaptchouk Jana V JV
Walters GB Walters G Bragi GB
Weedon MN Weedon Michael N MN
Wijmenga C Wijmenga Cisca C
Witteman J Witteman Jacqueline J
Bergman RN Bergman Richard N RN
Cauchi S Cauchi Stephane S
Collins FS Collins Francis S FS
Gloyn AL Gloyn Anna L AL
Gyllensten U Gyllensten Ulf U
Hansen T Hansen Torben T
Hide WA Hide Winston A WA
Hitman GA Hitman Graham A GA
Hofman A Hofman Albert A
Hunter DJ Hunter David J DJ
Hveem K Hveem Kristian K
Laakso M Laakso Markku M
Morris AD Morris Andrew D AD
Palmer CN Palmer Colin N A CN
Rudan I Rudan Igor I
Sijbrands E Sijbrands Eric E
Stein LD Stein Lincoln D LD
Tuomilehto J Tuomilehto Jaakko J
Uitterlinden A Uitterlinden Andre A
Walker M Walker Mark M
Watanabe RM Watanabe Richard M RM
Abecasis GR Abecasis Goncalo R GR
Boehm BO Boehm Bernhard O BO
Campbell H Campbell Harry H
Daly MJ Daly Mark J MJ
Hattersley AT Hattersley Andrew T AT
Pedersen O Pedersen Oluf O
Barroso I Barroso Inês I
Groop L Groop Leif L
Sladek R Sladek Rob R
Thorsteinsdottir U Thorsteinsdottir Unnur U
Wilson JF Wilson James F JF
Illig T Illig Thomas T
Froguel P Froguel Philippe P
van Duijn CM van Duijn Cornelia M CM
Stefansson K Stefansson Kari K
Altshuler D Altshuler David D
Boehnke M Boehnke Michael M
McCarthy MI McCarthy Mark I MI
Soranzo N Soranzo Nicole N
Wheeler E Wheeler Eleanor E
Glazer NL Glazer Nicole L NL
Bouatia-Naji N Bouatia-Naji Nabila N
Mägi R Mägi Reedik R
Randall J Randall Joshua J
Elliott P Elliott Paul P
Rybin D Rybin Denis D
Dehghan A Dehghan Abbas A
Hottenga JJ Hottenga Jouke Jan JJ
Song K Song Kijoung K
Goel A Goel Anuj A
Lajunen T Lajunen Taina T
Doney A Doney Alex A
Cavalcanti-Proença C Cavalcanti-Proença Christine C
Kumari M Kumari Meena M
Timpson NJ Timpson Nicholas J NJ
Zabena C Zabena Carina C
Ingelsson E Ingelsson Erik E
An P An Ping P
O'Connell J O'Connell Jeffrey J
Luan J Luan Jian'an J
Elliott A Elliott Amanda A
McCarroll SA McCarroll Steven A SA
Roccasecca RM Roccasecca Rosa Maria RM
Pattou F Pattou François F
Sethupathy P Sethupathy Praveen P
Ariyurek Y Ariyurek Yavuz Y
Barter P Barter Philip P
Beilby JP Beilby John P JP
Ben-Shlomo Y Ben-Shlomo Yoav Y
Bergmann S Bergmann Sven S
Bochud M Bochud Murielle M
Bonnefond A Bonnefond Amélie A
Borch-Johnsen K Borch-Johnsen Knut K
Böttcher Y Böttcher Yvonne Y
Brunner E Brunner Eric E
Bumpstead SJ Bumpstead Suzannah J SJ
Chen YD Chen Yii-Der Ida YD
Chines P Chines Peter P
Clarke R Clarke Robert R
Coin LJ Coin Lachlan J M LJ
Cooper MN Cooper Matthew N MN
Crisponi L Crisponi Laura L
Day IN Day Ian N M IN
de Geus EJ de Geus Eco J C EJ
Delplanque J Delplanque Jerome J
Fedson AC Fedson Annette C AC
Fischer-Rosinsky A Fischer-Rosinsky Antje A
Forouhi NG Forouhi Nita G NG
Franzosi MG Franzosi Maria Grazia MG
Galan P Galan Pilar P
Goodarzi MO Goodarzi Mark O MO
Graessler J Graessler Jürgen J
Grundy S Grundy Scott S
Gwilliam R Gwilliam Rhian R
Hallmans G Hallmans Göran G
Hammond N Hammond Naomi N
Han X Han Xijing X
Hartikainen AL Hartikainen Anna-Liisa AL
Hayward C Hayward Caroline C
Heath SC Heath Simon C SC
Hercberg S Hercberg Serge S
Hillman DR Hillman David R DR
Hingorani AD Hingorani Aroon D AD
Hui J Hui Jennie J
Hung J Hung Joe J
Kaakinen M Kaakinen Marika M
Kaprio J Kaprio Jaakko J
Kesaniemi YA Kesaniemi Y Antero YA
Kivimaki M Kivimaki Mika M
Knight B Knight Beatrice B
Koskinen S Koskinen Seppo S
Kovacs P Kovacs Peter P
Kyvik KO Kyvik Kirsten Ohm KO
Lathrop GM Lathrop G Mark GM
Lawlor DA Lawlor Debbie A DA
Le Bacquer O Le Bacquer Olivier O
Lecoeur C Lecoeur Cécile C
Li Y Li Yun Y
Mahley R Mahley Robert R
Mangino M Mangino Massimo M
Martínez-Larrad MT Martínez-Larrad María Teresa MT
McAteer JB McAteer Jarred B JB
McPherson R McPherson Ruth R
Meisinger C Meisinger Christa C
Melzer D Melzer David D
Meyre D Meyre David D
Mitchell BD Mitchell Braxton D BD
Mukherjee S Mukherjee Sutapa S
Naitza S Naitza Silvia S
Neville MJ Neville Matthew J MJ
Orrù M Orrù Marco M
Pakyz R Pakyz Ruth R
Paolisso G Paolisso Giuseppe G
Pattaro C Pattaro Cristian C
Pearson D Pearson Daniel D
Peden JF Peden John F JF
Pedersen NL Pedersen Nancy L NL
Pfeiffer AF Pfeiffer Andreas F H AF
Pichler I Pichler Irene I
Polasek O Polasek Ozren O
Posthuma D Posthuma Danielle D
Potter SC Potter Simon C SC
Pouta A Pouta Anneli A
Province MA Province Michael A MA
Rayner NW Rayner Nigel W NW
Rice K Rice Kenneth K
Ripatti S Ripatti Samuli S
Rivadeneira F Rivadeneira Fernando F
Rolandsson O Rolandsson Olov O
Sandbaek A Sandbaek Annelli A
Sandhu M Sandhu Manjinder M
Sanna S Sanna Serena S
Sayer AA Sayer Avan Aihie AA
Scheet P Scheet Paul P
Seedorf U Seedorf Udo U
Sharp SJ Sharp Stephen J SJ
Shields B Shields Beverley B
Sigurðsson G Sigurðsson Gunnar G
Sijbrands EJ Sijbrands Eric J G EJ
Silveira A Silveira Angela A
Simpson L Simpson Laila L
Singleton A Singleton Andrew A
Smith NL Smith Nicholas L NL
Sovio U Sovio Ulla U
Swift A Swift Amy A
Syddall H Syddall Holly H
Syvänen AC Syvänen Ann-Christine AC
Tönjes A Tönjes Anke A
Uitterlinden AG Uitterlinden André G AG
van Dijk KW van Dijk Ko Willems KW
Varma D Varma Dhiraj D
Visvikis-Siest S Visvikis-Siest Sophie S
Vitart V Vitart Veronique V
Vogelzangs N Vogelzangs Nicole N
Waeber G Waeber Gérard G
Wagner PJ Wagner Peter J PJ
Walley A Walley Andrew A
Ward KL Ward Kim L KL
Watkins H Watkins Hugh H
Wild SH Wild Sarah H SH
Willemsen G Willemsen Gonneke G
Witteman JC Witteman Jaqueline C M JC
Yarnell JW Yarnell John W G JW
Zelenika D Zelenika Diana D
Zethelius B Zethelius Björn B
Zhai G Zhai Guangju G
Zhao JH Zhao Jing Hua JH
Zillikens MC Zillikens M Carola MC
DIAGRAM Consortium
GIANT Consortium
Global B Pgen Consortium
Borecki IB Borecki Ingrid B IB
Meneton P Meneton Pierre P
Magnusson PK Magnusson Patrik K E PK
Nathan DM Nathan David M DM
Williams GH Williams Gordon H GH
Silander K Silander Kaisa K
Bornstein SR Bornstein Stefan R SR
Schwarz P Schwarz Peter P
Spranger J Spranger Joachim J
Karpe F Karpe Fredrik F
Shuldiner AR Shuldiner Alan R AR
Cooper C Cooper Cyrus C
Serrano-Ríos M Serrano-Ríos Manuel M
Lind L Lind Lars L
Palmer LJ Palmer Lyle J LJ
Hu FB 1st Hu Frank B FB
Franks PW Franks Paul W PW
Ebrahim S Ebrahim Shah S
Marmot M Marmot Michael M
Kao WH Kao W H Linda WH
Pramstaller PP Pramstaller Peter Paul PP
Wright AF Wright Alan F AF
Stumvoll M Stumvoll Michael M
Hamsten A Hamsten Anders A
Procardis Consortium
Buchanan TA Buchanan Thomas A TA
Valle TT Valle Timo T TT
Rotter JI Rotter Jerome I JI
Penninx BW Penninx Brenda W J H BW
Boomsma DI Boomsma Dorret I DI
Cao A Cao Antonio A
Scuteri A Scuteri Angelo A
Schlessinger D Schlessinger David D
Uda M Uda Manuela M
Ruokonen A Ruokonen Aimo A
Jarvelin MR Jarvelin Marjo-Riitta MR
Peltonen L Peltonen Leena L
Mooser V Mooser Vincent V
Sladek R Sladek Robert R
MAGIC investigators
GLGC Consortium
Musunuru K Musunuru Kiran K
Smith AV Smith Albert V AV
Edmondson AC Edmondson Andrew C AC
Stylianou IM Stylianou Ioannis M IM
Koseki M Koseki Masahiro M
Pirruccello JP Pirruccello James P JP
Chasman DI Chasman Daniel I DI
Johansen CT Johansen Christopher T CT
Fouchier SW Fouchier Sigrid W SW
Peloso GM Peloso Gina M GM
Barbalic M Barbalic Maja M
Ricketts SL Ricketts Sally L SL
Bis JC Bis Joshua C JC
Feitosa MF Feitosa Mary F MF
Orho-Melander M Orho-Melander Marju M
Melander O Melander Olle O
Li X Li Xiaohui X
Li M Li Mingyao M
Cho YS Cho Yoon Shin YS
Go MJ Go Min Jin MJ
Kim YJ Kim Young Jin YJ
Lee JY Lee Jong-Young JY
Park T Park Taesung T
Kim K Kim Kyunga K
Sim X Sim Xueling X
Ong RT Ong Rick Twee-Hee RT
Croteau-Chonka DC Croteau-Chonka Damien C DC
Lange LA Lange Leslie A LA
Smith JD Smith Joshua D JD
Ziegler A Ziegler Andreas A
Zhang W Zhang Weihua W
Zee RY Zee Robert Y L RY
Whitfield JB Whitfield John B JB
Thompson JR Thompson John R JR
Surakka I Surakka Ida I
Spector TD Spector Tim D TD
Smit JH Smit Johannes H JH
Sinisalo J Sinisalo Juha J
Scott J Scott James J
Saharinen J Saharinen Juha J
Sabatti C Sabatti Chiara C
Rose LM Rose Lynda M LM
Roberts R Roberts Robert R
Rieder M Rieder Mark M
Parker AN Parker Alex N AN
Pare G Pare Guillaume G
O'Donnell CJ O'Donnell Christopher J CJ
Nieminen MS Nieminen Markku S MS
Nickerson DA Nickerson Deborah A DA
Montgomery GW Montgomery Grant W GW
McArdle W McArdle Wendy W
Masson D Masson David D
Martin NG Martin Nicholas G NG
Marroni F Marroni Fabio F
Lucas G Lucas Gavin G
Luben R Luben Robert R
Lokki ML Lokki Marja-Liisa ML
Lettre G Lettre Guillaume G
Launer LJ Launer Lenore J LJ
Lakatta EG Lakatta Edward G EG
Laaksonen R Laaksonen Reijo R
Kyvik KO Kyvik Kirsten O KO
König IR König Inke R IR
Khaw KT Khaw Kay-Tee KT
Kaplan LM Kaplan Lee M LM
Johansson Å Johansson Åsa
Janssens AC Janssens A Cecile J W AC
Igl W Igl Wilmar W
Hovingh GK Hovingh G Kees GK
Hengstenberg C Hengstenberg Christian C
Havulinna AS Havulinna Aki S AS
Hastie ND Hastie Nicholas D ND
Harris TB Harris Tamara B TB
Haritunians T Haritunians Talin T
Hall AS Hall Alistair S AS
Groop LC Groop Leif C LC
Gonzalez E Gonzalez Elena E
Freimer NB Freimer Nelson B NB
Erdmann J Erdmann Jeanette J
Ejebe KG Ejebe Kenechi G KG
Döring A Döring Angela A
Dominiczak AF Dominiczak Anna F AF
Demissie S Demissie Serkalem S
Deloukas P Deloukas Panagiotis P
de Faire U de Faire Ulf U
Crawford G Crawford Gabriel G
Chen YD Chen Yii-der I YD
Caulfield MJ Caulfield Mark J MJ
Boekholdt SM Boekholdt S Matthijs SM
Assimes TL Assimes Themistocles L TL
Quertermous T Quertermous Thomas T
Seielstad M Seielstad Mark M
Wong TY Wong Tien Y TY
Tai ES Tai E-Shyong ES
Feranil AB Feranil Alan B AB
Kuzawa CW Kuzawa Christopher W CW
Taylor HA Jr Taylor Herman A HA
Gabriel SB Gabriel Stacey B SB
Holm H Holm Hilma H
Gudnason V Gudnason Vilmundur V
Krauss RM Krauss Ronald M RM
Ordovas JM Ordovas Jose M JM
Munroe PB Munroe Patricia B PB
Kooner JS Kooner Jaspal S JS
Tall AR Tall Alan R AR
Hegele RA Hegele Robert A RA
Kastelein JJ Kastelein John J P JJ
Schadt EE Schadt Eric E EE
Strachan DP Strachan David P DP
Reilly MP Reilly Muredach P MP
Samani NJ Samani Nilesh J NJ
Schunkert H Schunkert Heribert H
Cupples LA Cupples L Adrienne LA
Sandhu MS Sandhu Manjinder S MS
Ridker PM Ridker Paul M PM
Rader DJ Rader Daniel J DJ
Kathiresan S Kathiresan Sekar S
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Olson Jean J
Kronmal Richard R
Robbins John J
Chaves Paulo H PH
Burke Gregory G
Kuller Lewis H LH
Tracy Russell R
Gottdiener John J
Prineas Ronald R
Becker James T JT
Enright Paul P
Klein Ronald R
O'Leary Daniel H DH
JOURNAL
VOLUME: 8
ISSUE: 3
TITLE: PLoS genetics
ISOABBREVIATION: PLoS Genet.
YEAR: 2012
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1553-7404
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: PLoS Genet
COUNTRY: United States
ISSNLINKING: 1553-7390
NLMUNIQUEID: 101239074
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
064890 Wellcome Trust United Kingdom
081682 Wellcome Trust United Kingdom
090532 Wellcome Trust United Kingdom
092731 Wellcome Trust United Kingdom
1 R01 DK075787-01A1 NIDDK NIH HHS United States
1R01AG032098-01A1 NIA NIH HHS United States
CZB/4/710 Chief Scientist Office United Kingdom
DHCS/07/07/008 Department of Health United Kingdom
DK063491 NIDDK NIH HHS United States
DK078150 NIDDK NIH HHS United States
DK56350 NIDDK NIH HHS United States
ES10126 NIEHS NIH HHS United States
G0100222 Medical Research Council United Kingdom
G0401527 Medical Research Council United Kingdom
G0600705 Medical Research Council United Kingdom
G0601966 Medical Research Council United Kingdom
G0700931 Medical Research Council United Kingdom
G0701863 Medical Research Council United Kingdom
G0800582 Medical Research Council United Kingdom
G0801056 Medical Research Council United Kingdom
G0900339 Medical Research Council United Kingdom
G0901213 Medical Research Council United Kingdom
G0902037 Medical Research Council United Kingdom
G1000143 Medical Research Council United Kingdom
G19/35 Medical Research Council United Kingdom
G20234 Biotechnology and Biological Sciences Research Council United Kingdom
G8802774 Medical Research Council United Kingdom
HHSN268200625226C PHS HHS United States
HHSN268200782096C PHS HHS United States
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MC_U127561128 Medical Research Council United Kingdom
MC_U127592696 Medical Research Council United Kingdom
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PG/08/094/26019 British Heart Foundation United Kingdom
PG/09/002/26056 British Heart Foundation United Kingdom
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R01 DK078150 NIDDK NIH HHS United States
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R01 HL087652 NHLBI NIH HHS United States
R01-HL085251 NHLBI NIH HHS United States
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R01HL087641 NHLBI NIH HHS United States
R01HL59367 NHLBI NIH HHS United States
R24 HD050924 NICHD NIH HHS United States
R69/0208 The Dunhill Medical Trust United Kingdom
RC2 HL102419 NHLBI NIH HHS United States
RG/07/008/23674 British Heart Foundation United Kingdom
RR-024156 NCRR NIH HHS United States
RR20649 NCRR NIH HHS United States
TW05596 FIC NIH HHS United States
U01 HL080295 NHLBI NIH HHS United States
U01HG004402 NHGRI NIH HHS United States
UL1 RR025008 NCRR NIH HHS United States
UL1 RR025008 NCRR NIH HHS United States
UL1 TR000124 NCATS NIH HHS United States
UL1 TR000454 NCATS NIH HHS United States
UL1RR025005 NCRR NIH HHS United States
Canadian Institutes of Health Research Canada
Intramural NIH HHS United States
Medical Research Council United Kingdom
Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adiponectin genetics
African Americans genetics
Asian Continental Ancestry Group genetics
Cholesterol, HDL genetics
Diabetes Mellitus, Type 2 genetics
European Continental Ancestry Group genetics
Female genetics
Gene Expression genetics
Genetic Predisposition to Disease genetics
Genome-Wide Association Study genetics
Glucose Tolerance Test genetics
Humans genetics
Insulin Resistance genetics
Male genetics
Metabolic Networks and Pathways genetics
Polymorphism, Single Nucleotide genetics
Waist-Hip Ratio genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Adiponectin
0 Cholesterol, HDL
OTHER ID's
OTHERID SOURCE
PMC3315470 NLM