Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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22001757
TITLE
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
ABSTRACT
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10(-8) to P = 10(-190)). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function.
DATE PUBLISHED
2011 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2011/03/08
accepted 2011/09/12
aheadofprint 2011/10/16
entrez 2011/10/18 06:00
pubmed 2011/10/18 06:00
medline 2011/12/20 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Chambers JC Chambers John C JC Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK. john.chambers@ic.ac.uk
Zhang W Zhang Weihua W
Sehmi J Sehmi Joban J
Li X Li Xinzhong X
Wass MN Wass Mark N MN
Van der Harst P Van der Harst Pim P
Holm H Holm Hilma H
Sanna S Sanna Serena S
Kavousi M Kavousi Maryam M
Baumeister SE Baumeister Sebastian E SE
Coin LJ Coin Lachlan J LJ
Deng G Deng Guohong G
Gieger C Gieger Christian C
Heard-Costa NL Heard-Costa Nancy L NL
Hottenga JJ Hottenga Jouke-Jan JJ
Kühnel B Kühnel Brigitte B
Kumar V Kumar Vinod V
Lagou V Lagou Vasiliki V
Liang L Liang Liming L
Luan J Luan Jian'an J
Vidal PM Vidal Pedro Marques PM
Mateo Leach I Mateo Leach Irene I
O'Reilly PF O'Reilly Paul F PF
Peden JF Peden John F JF
Rahmioglu N Rahmioglu Nilufer N
Soininen P Soininen Pasi P
Speliotes EK Speliotes Elizabeth K EK
Yuan X Yuan Xin X
Thorleifsson G Thorleifsson Gudmar G
Alizadeh BZ Alizadeh Behrooz Z BZ
Atwood LD Atwood Larry D LD
Borecki IB Borecki Ingrid B IB
Brown MJ Brown Morris J MJ
Charoen P Charoen Pimphen P
Cucca F Cucca Francesco F
Das D Das Debashish D
de Geus EJ de Geus Eco J C EJ
Dixon AL Dixon Anna L AL
Döring A Döring Angela A
Ehret G Ehret Georg G
Eyjolfsson GI Eyjolfsson Gudmundur I GI
Farrall M Farrall Martin M
Forouhi NG Forouhi Nita G NG
Friedrich N Friedrich Nele N
Goessling W Goessling Wolfram W
Gudbjartsson DF Gudbjartsson Daniel F DF
Harris TB Harris Tamara B TB
Hartikainen AL Hartikainen Anna-Liisa AL
Heath S Heath Simon S
Hirschfield GM Hirschfield Gideon M GM
Hofman A Hofman Albert A
Homuth G Homuth Georg G
Hyppönen E Hyppönen Elina E
Janssen HL Janssen Harry L A HL
Johnson T Johnson Toby T
Kangas AJ Kangas Antti J AJ
Kema IP Kema Ido P IP
Kühn JP Kühn Jens P JP
Lai S Lai Sandra S
Lathrop M Lathrop Mark M
Lerch MM Lerch Markus M MM
Li Y Li Yun Y
Liang TJ Liang T Jake TJ
Lin JP Lin Jing-Ping JP
Loos RJ Loos Ruth J F RJ
Martin NG Martin Nicholas G NG
Moffatt MF Moffatt Miriam F MF
Montgomery GW Montgomery Grant W GW
Munroe PB Munroe Patricia B PB
Musunuru K Musunuru Kiran K
Nakamura Y Nakamura Yusuke Y
O'Donnell CJ O'Donnell Christopher J CJ
Olafsson I Olafsson Isleifur I
Penninx BW Penninx Brenda W BW
Pouta A Pouta Anneli A
Prins BP Prins Bram P BP
Prokopenko I Prokopenko Inga I
Puls R Puls Ralf R
Ruokonen A Ruokonen Aimo A
Savolainen MJ Savolainen Markku J MJ
Schlessinger D Schlessinger David D
Schouten JN Schouten Jeoffrey N L JN
Seedorf U Seedorf Udo U
Sen-Chowdhry S Sen-Chowdhry Srijita S
Siminovitch KA Siminovitch Katherine A KA
Smit JH Smit Johannes H JH
Spector TD Spector Timothy D TD
Tan W Tan Wenting W
Teslovich TM Teslovich Tanya M TM
Tukiainen T Tukiainen Taru T
Uitterlinden AG Uitterlinden Andre G AG
Van der Klauw MM Van der Klauw Melanie M MM
Vasan RS Vasan Ramachandran S RS
Wallace C Wallace Chris C
Wallaschofski H Wallaschofski Henri H
Wichmann HE Wichmann H-Erich HE
Willemsen G Willemsen Gonneke G
Würtz P Würtz Peter P
Xu C Xu Chun C
Yerges-Armstrong LM Yerges-Armstrong Laura M LM
Alcohol Genome-wide Association (AlcGen) Consortium
Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study
Genetic Investigation of Anthropometric Traits (GIANT) Consortium
Global Lipids Genetics Consortium
Genetics of Liver Disease (GOLD) Consortium
International Consortium for Blood Pressure (ICBP-GWAS)
Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC)
Abecasis GR Abecasis Goncalo R GR
Ahmadi KR Ahmadi Kourosh R KR
Boomsma DI Boomsma Dorret I DI
Caulfield M Caulfield Mark M
Cookson WO Cookson William O WO
van Duijn CM van Duijn Cornelia M CM
Froguel P Froguel Philippe P
Matsuda K Matsuda Koichi K
McCarthy MI McCarthy Mark I MI
Meisinger C Meisinger Christa C
Mooser V Mooser Vincent V
Pietiläinen KH Pietiläinen Kirsi H KH
Schumann G Schumann Gunter G
Snieder H Snieder Harold H
Sternberg MJ Sternberg Michael J E MJ
Stolk RP Stolk Ronald P RP
Thomas HC Thomas Howard C HC
Thorsteinsdottir U Thorsteinsdottir Unnur U
Uda M Uda Manuela M
Waeber G Waeber Gérard G
Wareham NJ Wareham Nicholas J NJ
Waterworth DM Waterworth Dawn M DM
Watkins H Watkins Hugh H
Whitfield JB Whitfield John B JB
Witteman JC Witteman Jacqueline C M JC
Wolffenbuttel BH Wolffenbuttel Bruce H R BH
Fox CS Fox Caroline S CS
Ala-Korpela M Ala-Korpela Mika M
Stefansson K Stefansson Kari K
Vollenweider P Vollenweider Peter P
Völzke H Völzke Henry H
Schadt EE Schadt Eric E EE
Scott J Scott James J
Järvelin MR Järvelin Marjo-Riitta MR
Elliott P Elliott Paul P
Kooner JS Kooner Jaspal S JS
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Voight Benjamin F BF
Scott Laura J LJ
Steinthorsdottir Valgerdur V
Morris Andrew P AP
Dina Christian C
Welch Ryan P RP
Zeggini Eleftheria E
Huth Cornelia C
Aulchenko Yurii S YS
Thorleifsson Gudmar G
McCulloch Laura J LJ
Ferreira Teresa T
Grallert Harald H
Amin Najaf N
Wu Guanming G
Willer Cristen J CJ
Raychaudhuri Soumya S
McCarroll Steve A SA
Langenberg Claudia C
Hofmann Oliver M OM
Dupuis Josée J
Qi Lu L
Segrè Ayellet V AV
van Hoek Mandy M
Navarro Pau P
Ardlie Kristin K
Balkau Beverley B
Benediktsson Rafn R
Bennett Amanda J AJ
Blagieva Roza R
Boerwinkle Eric E
Bonnycastle Lori L LL
Bengtsson Boström Kristina K
Bravenboer Bert B
Bumpstead Suzannah S
Burtt Noël P NP
Charpentier Guillaume G
Chines Peter S PS
Cornelis Marilyn M
Couper David J DJ
Crawford Gabe G
Doney Alex S F AS
Elliott Katherine S KS
Elliott Amanda L AL
Erdos Michael R MR
Fox Caroline S CS
Franklin Christopher S CS
Ganser Martha M
Gieger Christian C
Grarup Niels N
Green Todd T
Griffin Simon S
Groves Christopher J CJ
Guiducci Candace C
Hadjadj Samy S
Hassanali Neelam N
Herder Christian C
Isomaa Bo B
Jackson Anne U AU
Johnson Paul R V PR
Jørgensen Torben T
Kao Wen H L WH
Klopp Norman N
Kong Augustine A
Kraft Peter P
Kuusisto Johanna J
Lauritzen Torsten T
Li Man M
Lieverse Aloysius A
Lindgren Cecilia M CM
Lyssenko Valeriya V
Marre Michel M
Meitinger Thomas T
Midthjell Kristian K
Morken Mario A MA
Narisu Narisu N
Nilsson Peter P
Owen Katharine R KR
Payne Felicity F
Perry John R B JR
Petersen Ann-Kristin AK
Platou Carl C
Proença Christine C
Prokopenko Inga I
Rathmann Wolfgang W
William Rayner N N
Robertson Neil R NR
Rocheleau Ghislain G
Roden Michael M
Sampson Michael J MJ
Saxena Richa R
Shields Beverley M BM
Shrader Peter P
Sigurdsson Gunnar G
Sparsø Thomas T
Strassburger Klaus K
Stringham Heather M HM
Sun Qi Q
Swift Amy J AJ
Thorand Barbara B
Tichet Jean J
Tuomi Tiinamaija T
van Dam Rob M RM
van Haeften Timon W TW
van Herpt Thijs T
van Vliet-Ostaptchouk Jana V JV
Walters G Bragi GB
Weedon Michael N MN
Wijmenga Cisca C
Witteman Jacqueline J
Bergman Richard N RN
Cauchi Stephane S
Collins Francis S FS
Gloyn Anna L AL
Gyllensten Ulf U
Hansen Torben T
Hide Winston A WA
Hitman Graham A GA
Hofman Albert A
Hunter David J DJ
Hveem Kristian K
Laakso Markku M
Mohlke Karen L KL
Morris Andrew D AD
Palmer Colin N A CN
Pramstaller Peter P PP
Rudan Igor I
Sijbrands Eric E
Stein Lincoln D LD
Tuomilehto Jaakko J
Uitterlinden Andre A
Walker Mark M
Wareham Nicholas J NJ
Watanabe Richard M RM
Abecasis Goncalo R GR
Boehm Bernhard O BO
Campbell Harry H
Daly Mark J MJ
Hattersley Andrew T AT
Hu Frank B FB
Meigs James B JB
Pankow James S JS
Pedersen Oluf O
Wichmann H-Erich HE
Barroso Inês I
Florez Jose C JC
Frayling Timothy M TM
Groop Leif L
Sladek Rob R
Thorsteinsdottir Unnur U
Wilson James F JF
Illig Thomas T
Froguel Philippe P
van Duijn Cornelia M CM
Stefansson Kari K
Altshuler David D
Boehnke Michael M
McCarthy Mark I MI
Lango Allen H H
Estrada K K
Lettre G G
Berndt S I SI
Weedon M N MN
Rivadeneira F F
Willer C J CJ
Jackson A U AU
Vedantam S S
Raychaudhuri S S
Ferreira T T
Wood A R AR
Weyant R J RJ
Segrè A V AV
Speliotes E K EK
Wheeler E E
Soranzo N N
Park J H JH
Yang J J
Gudbjartsson D D
Heard-Costa N L NL
Randall J C JC
Qi L L
Smith A Vernon AV
Mägi R R
Pastinen T T
Liang L L
Heid I M IM
Luan J J
Thorleifsson G G
Winkler T W TW
Goddard M E ME
Sin Lo K K
Palmer C C
Workalemahu T T
Aulchenko Y S YS
Johansson A A
Zillikens M C MC
Feitosa M F MF
Esko T T
Johnson T T
Ketkar S S
Kraft P P
Mangino M M
Prokopenko I I
Absher D D
Albrecht E E
Ernst F F
Glazer N L NL
Hayward C C
Hottenga J J JJ
Jacobs K B KB
Knowles J W JW
Kutalik Z Z
Monda K L KL
Polasek O O
Preuss M M
Rayner N W NW
Robertson N R NR
Steinthorsdottir V V
Tyrer J P JP
Voight B F BF
Wiklund F F
Xu J J
Zhao J Hua JH
Nyholt D R DR
Pellikka N N
Perola M M
Perry J R JR
Surakka I I
Tammesoo M L ML
Altmaier E L EL
Amin N N
Aspelund T T
Bhangale T T
Boucher G G
Chasman D I DI
Chen C C
Coin L L
Cooper M N MN
Dixon A L AL
Gibson Q Q
Grundberg E E
Hao K K
Juhani Junttila M M
Kaplan L M LM
Kettunen J J
König I R IR
Kwan T T
Lawrence R W RW
Levinson D F DF
Lorentzon M M
McKnight B B
Morris A P AP
Müller M M
Suh Ngwa J J
Purcell S S
Rafelt S S
Salem R M RM
Salvi E E
Sanna S S
Shi J J
Sovio U U
Thompson J R JR
Turchin M C MC
Vandenput L L
Verlaan D J DJ
Vitart V V
White C C CC
Ziegler A A
Almgren P P
Balmforth A J AJ
Campbell H H
Citterio L L
De Grandi A A
Dominiczak A A
Duan J J
Elliott P P
Elosua R R
Eriksson J G JG
Freimer N B NB
Geus E J EJ
Glorioso N N
Haiqing S S
Hartikainen A L AL
Havulinna A S AS
Hicks A A AA
Hui J J
Igl W W
Illig T T
Jula A A
Kajantie E E
Kilpeläinen T O TO
Koiranen M M
Kolcic I I
Koskinen S S
Kovacs P P
Laitinen J J
Liu J J
Lokki M L ML
Marusic A A
Maschio A A
Meitinger T T
Mulas A A
Paré G G
Parker A N AN
Peden J F JF
Petersmann A A
Pichler I I
Pietiläinen K H KH
Pouta A A
Ridderstråle M M
Rotter J I JI
Sambrook J G JG
Sanders A R AR
Schmidt C Oliver CO
Sinisalo J J
Smit J H JH
Stringham H M HM
Walters G Bragi GB
Widen E E
Wild S H SH
Willemsen G G
Zagato L L
Zgaga L L
Zitting P P
Alavere H H
Farrall M M
McArdle W L WL
Nelis M M
Peters M J MJ
Ripatti S S
van Meurs J B JB
Aben K K KK
Ardlie K G KG
Beckmann J S JS
Beilby J P JP
Bergman R N RN
Bergmann S S
Collins F S FS
Cusi D D
den Heijer M M
Eiriksdottir G G
Gejman P V PV
Hamsten A A
Huikuri H V HV
Iribarren C C
Kähönen M M
Kaprio J J
Kathiresan S S
Kiemeney L L
Kocher T T
Launer L J LJ
Lehtimäki T T
Melander O O
Mosley T H TH
Musk A W AW
Nieminen M S MS
O'Donnell C J CJ
Ohlsson C C
Oostra B B
Palmer L J LJ
Raitakari O O
Ridker P M PM
Rioux J D JD
Rissanen A A
Rivolta C C
Schunkert H H
Shuldiner A R AR
Siscovick D S DS
Stumvoll M M
Tönjes A A
Tuomilehto J J
van Ommen G J GJ
Viikari J J
Heath A C AC
Martin N G NG
Montgomery G W GW
Province M A MA
Kayser M M
Arnold A M AM
Atwood L D LD
Boerwinkle E E
Chanock S J SJ
Deloukas P P
Gieger C C
Grönberg H H
Hall P P
Hattersley A T AT
Hengstenberg C C
Hoffman W W
Lathrop G Mark GM
Salomaa V V
Schreiber S S
Uda M M
Waterworth D D
Wright A F AF
Assimes T L TL
Barroso I I
Hofman A A
Mohlke K L KL
Boomsma D I DI
Caulfield M J MJ
Cupples L Adrienne LA
Erdmann J J
Fox C S CS
Gudnason V V
Gyllensten U U
Harris T B TB
Hayes R B RB
Jarvelin M R MR
Mooser V V
Munroe P B PB
Ouwehand W H WH
Penninx B W BW
Pramstaller P P PP
Quertermous T T
Rudan I I
Samani N J NJ
Spector T D TD
Völzke H H
Watkins H H
Wilson J F JF
Groop L C LC
Haritunians T T
Hu F B FB
Kaplan R C RC
Metspalu A A
North K E KE
Schlessinger D D
Wareham N J NJ
Hunter D J DJ
O'Connell J R JR
Strachan D P DP
Wichmann H E HE
Borecki I B IB
van Duijn C M CM
Schadt E E EE
Thorsteinsdottir U U
Peltonen L L
Uitterlinden A G AG
Visscher P M PM
Chatterjee N N
Loos R J RJ
Boehnke M M
McCarthy M I MI
Ingelsson E E
Lindgren C M CM
Abecasis G R GR
Stefansson K K
Frayling T M TM
Hirschhorn J N JN
Teslovich T M TM
Musunuru K K
Smith A V AV
Edmondson A C AC
Stylianou I M IM
Koseki M M
Pirruccello J P JP
Ripatti S S
Chasman D I DI
Willer C J CJ
Johansen C T CT
Fouchier S W SW
Isaacs A A
Peloso G M GM
Barbalic M M
Ricketts S L SL
Bis J C JC
Aulchenko Y S YS
Thorleifsson G G
Feitosa M F MF
Chambers J J
Orho-Melander M M
Melander O O
Johnson T T
Li X X
Guo X X
Li M M
Cho Y Shin YS
Go M Jin MJ
Kim Y Jin YJ
Lee J Y JY
Park T T
Kim K K
Sim X X
Ong R Twee-Hee RT
Croteau-Chonka D C DC
Lange L A LA
Smith J D JD
Song K K
Zhao J Hua JH
Yuan X X
Luan J J
Lamina C C
Ziegler A A
Zhang W W
Zee R Y RY
Wright A F AF
Witteman J C JC
Wilson J F JF
Willemsen G G
Wichmann H E HE
Whitfield J B JB
Waterworth D M DM
Wareham N J NJ
Waeber G G
Vollenweider P P
Voight B F BF
Vitart V V
Uitterlinden A G AG
Uda M M
Tuomilehto J J
Thompson J R JR
Tanaka T T
Surakka I I
Stringham H M HM
Spector T D TD
Soranzo N N
Smit J H JH
Sinisalo J J
Silander K K
Sijbrands E J EJ
Scuteri A A
Scott J J
Schlessinger D D
Sanna S S
Salomaa V V
Salomaa J J
Sabatti C C
Ruokonen A A
Rudan I I
Rose L M LM
Roberts R R
Rieder M M
Psaty B M BM
Pramstaller P P PP
Pichler I I
Perola M M
Penninx B W BW
Pedersen N L NL
Pattaro C C
Pare G G
Oostra B A BA
O'Donnell C J CJ
Nieminen M S MS
Nickerson D A DA
Montgomery G W GW
Meitinger T T
McPherson R R
McCarthy M I MI
McArdle W W
Masson D D
Martin N G NG
Marroni F F
Mangino M M
Magnusson P K PK
Lucas G G
Luben R R
Loos R J RJ
Lokki M L ML
Lettre G G
Langenberg C C
Launer L J LJ
Lakatta E G EG
Laaksonen R R
Kyvik K O KO
Kronenberg F F
König I R IR
Khaw K T KT
Kaprio J J
Kaplan L M LM
Johansson A A
Jarvelin M R MR
Janssens A C AC
Ingelsson E E
Igl W W
Hovingh G Kees GK
Hottenga J J JJ
Hofman A A
Hicks A A AA
Hengstenberg C C
Heid I M IM
Hayward C C
Havulinna A S AS
Hastie N D ND
Harris T B TB
Haritunians T T
Hall A S AS
Gyllensten U U
Guiducci C C
Groop L C LC
Gonzalez E E
Gieger C C
Gieger N B NB
Ferrucci L L
Erdmann J J
Elliott P P
Ejebe K G KG
Döring A A
Dominiczak A F AF
Demissie S S
Deloukas P P
de Geus E J EJ
de Faire U U
Crawford G G
Collins F S FS
Chen Y D YD
Caulfield M J MJ
Campbell H H
Burtt N P NP
Bonnycastle L L LL
Boomsma D I DI
Boekholdt S M SM
Bergman R N RN
Barroso I I
Bandinelli S S
Ballantyne C M CM
Ballantyne T L TL
Quertermous T T
Altshuler D D
Seielstad M M
Wong T Y TY
Tai E S ES
Feranil A B AB
Kuzawa C W CW
Adair L S LS
Taylor H A HA
Borecki I B IB
Gabriel S B SB
Wilson J G JG
Holm H H
Thorsteinsdottir U U
Gudnason V V
Krauss R M RM
Mohlke K L KL
Ordovas J M JM
Munroe P B PB
Kooner J S JS
Tall A R AR
Hegele R A RA
Kastelein J J JJ
Schadt E E EE
Rotter J I JI
Boerwinkle E E
Strachan D P DP
Mooser V V
Stefansson K K
Reilly M P MP
Samani N J NJ
Schunkert H H
Cupples L A LA
Sandhu M S MS
Ridker P M PM
Rader D J DJ
van Duijn C M CM
Peltonen L L
Abecasis G R GR
Boehnke M M
Kathiresan S S
Speliotes Elizabeth K EK
Yerges-Armstrong Laura M LM
Hernaez Ruben R
Kim Lauren J LJ
Palmer Cameron D CD
Gudnason Vilmundur V
Eiriksdottir Gudny G
Garcia Melissa E ME
Launer Lenore J LJ
Nalls Michael A MA
Clark Jeanne M JM
Mitchell Braxton D BD
Shuldiner Alan R AR
Butler Johannah L JL
Tomas Marta M
Hoffmann Udo U
Hwang Shih-Jen SJ
Massaro Joseph M JM
O'Donnell Christopher J CJ
Sahani Dushyant V DV
Salomaa Veikko V
Schadt Eric E EE
Schwartz Stephen M SM
Siscovick David S DS
Voight Benjamin F BF
Carr J Jeffrey JJ
Feitosa Mary F MF
Harris Tamara B TB
Fox Caroline S CS
Smith Albert V AV
Kao W H Linda WH
Hirschhorn Joel N JN
Borecki Ingrid B IB
Ehret Georg B GB
Munroe Patricia B PB
Rice Kenneth M KM
Bochud Murielle M
Johnson Andrew D AD
Chasman Daniel I DI
Smith Albert V AV
Tobin Martin D MD
Verwoert Germaine C GC
Hwang Shih-Jen SJ
Pihur Vasyl V
Vollenweider Peter P
O'Reilly Paul F PF
Amin Najaf N
Bragg-Gresham Jennifer L JL
Teumer Alexander A
Glazer Nicole L NL
Launer Lenore L
Zhao Jing Hua JH
Aulchenko Yurii Y
Heath Simon S
Sober Siim S
Parsa Afshin A
Luan Jian'an J
Arora Pankaj P
Dehghan Abbas A
Zhang Feng F
Lucas Gavin G
Hicks Andrew A AA
Jackson Anne U AU
Peden John F JF
Tanaka Toshiko T
Wild Sarah H SH
Rudan Igor I
Igl Wilmar W
Milaneschi Yuri Y
Parker Alex N AN
Fava Cristiano C
Chambers John C JC
Fox Ervin R ER
Kumari Meena M
Go Min Jin MJ
van der Harst Pim P
Kao Wen Hong Linda WH
Sjogren Marketa M
Vinay D G DG
Alexander Myriam M
Tabara Yasuharu Y
Shaw-Hawkins Sue S
Whincup Peter H PH
Liu Yongmei Y
Shi Gang G
Kuusisto Johanna J
Tayo Bamidele B
Seielstad Mark M
Sim Xueling X
Nguyen Khanh-Dung Hoang KD
Lehtimaki Terho T
Matullo Giuseppe G
Wu Ying Y
Gaunt Tom R TR
Onland-Moret N Charlotte NC
Cooper Matthew N MN
Platou Carl G P CG
Org Elin E
Hardy Rebecca R
Dahgam Santosh S
Palmen Jutta J
Vitart Veronique V
Braund Peter S PS
Kuznetsova Tatiana T
Uiterwaal Cuno S P M CS
Adeyemo Adebowale A
Palmas Walter W
Campbell Harry H
Ludwig Barbara B
Tomaszewski Maciej M
Tzoulaki Ioanna I
Palmer Nicholette D ND
Aspelund Thor T
Garcia Melissa M
Chang Yen-Pei C YP
O'Connell Jeffrey R JR
Steinle Nanette I NI
Grobbee Diederick E DE
Arking Dan E DE
Kardia Sharon L SL
Morrison Alanna C AC
Hernandez Dena D
Najjar Samer S
McArdle Wendy L WL
Hadley David D
Brown Morris J MJ
Connell John M JM
Hingorani Aroon D AD
Day Ian N M IN
Lawlor Debbie A DA
Beilby John P JP
Lawrence Robert W RW
Clarke Robert R
Collins Rory R
Hopewell Jemma C JC
Ongen Halit H
Dreisbach Albert W AW
Li Yali Y
Young J H JH
Bis Joshua C JC
Kahonen Mika M
Viikari Jorma J
Adair Linda S LS
Lee Nanette R NR
Chen Ming-Huei MH
Olden Matthias M
Pattaro Cristian C
Bolton Judith A Hoffman JA
Kottgen Anna A
Bergmann Sven S
Mooser Vincent V
Chaturvedi Nish R NR
Frayling Timothy M TM
Islam Muhammad M
Jafar Tazeen H TH
Erdmann Jeanette J
Kulkarni Smita R SR
Bornstein Stefan R SR
Grassler Jurgen J
Groop Leif L
Voight Benjamin F BF
Kettunen Johannes J
Howard Philip P
Taylor Andrew A
Guarrera Simonetta S
Ricceri Fulvio F
Emilsson Valur V
Plump Andrew A
Barroso Ines I
Khaw Kay-Tee KT
Weder Alan B AB
Hunt Steven C SC
Sun Yan V YV
Bergman Richard N RN
Collins Francis S FS
Bonnycastle Lori L LL
Scott Laura J LJ
Stringham Heather M HM
Peltonen Leena L
Perola Markus M
Vartiainen Erkki E
Brand Stefan-Martin SM
Staessen Jan A JA
Wang Thomas J TJ
Burton Paul R PR
Artigas Maria Soler MS
Dong Yanbin Y
Snieder Harold H
Wang Xiaoling X
Zhu Haidong H
Lohman Kurt K KK
Rudock Megan E ME
Heckbert Susan R SR
Smith Nicholas L NL
Wiggins Kerri L KL
Doumatey Ayo A
Shriner Daniel D
Veldre Gudrun G
Viigimaa Margus M
Kinra Sanjay S
Prabhakaran Dorairajan D
Tripathy Vikal V
Langefeld Carl D CD
Rosengren Annika A
Thelle Dag S DS
Corsi Anna Maria AM
Singleton Andrew A
Forrester Terrence T
Hilton Gina G
McKenzie Colin A CA
Salako Tunde T
Iwai Naoharu N
Kita Yoshikuni Y
Ogihara Toshio T
Ohkubo Takayoshi T
Okamura Tomonori T
Ueshima Hirotsugu H
Umemura Satoshi S
Eyheramendy Susana S
Meitinger Thomas T
Wichmann H-Erich HE
Cho Yoon Shin YS
Kim Hyung-Lae HL
Lee Jong-Young JY
Scott James J
Sehmi Joban S JS
Zhang Weihua W
Hedblad Bo B
Nilsson Peter P
Smith George Davey GD
Wong Andrew A
Narisu Narisu N
Stančakova Alena A
Raffel Leslie J LJ
Yao Jie J
Kathiresan Sekar S
O'Donnell Chris C
Schwartz Steven M SM
Ikram M Arfan MA
Longstreth Will T WT
Mosley Thomas H TH
Seshadri Sudha S
Shrine Nick R G NR
Wain Louise V LV
Morken Mario A MA
Swift Amy J AJ
Laitinen Jaana J
Prokopenko Inga I
Zitting Paavo P
Cooper Jackie A JA
Humphries Steve E SE
Danesh John J
Rasheed Asif A
Goel Anuj A
Hamsten Anders A
Watkins Hugh H
Bakker Stephan J L SJ
van Gilst Wiek H WH
Janipalli Charles S CS
Mani K Radha KR
Yajnik Chittaranjan S CS
Hofman Albert A
Mattace-Raso Francesco U S FU
Oostra Ben A BA
Demirkan Ayse A
Isaacs Aaron A
Rivadeneira Fernando F
Lakatta Edward G EG
Orru Marco M
Scuteri Angelo A
Ala-Korpela Mika M
Kangas Antti J AJ
Lyytikainen Leo-Pekka LP
Soininen Pasi P
Tukiainen Taru T
Wurz Peter P
Ong Rick Twee-Hee RT
Dorr Marcus M
Kroemer Heyo K HK
Volker Uwe U
Volzke Henry H
Galan Pilar P
Hercberg Serge S
Lathrop Mark M
Zelenika Diana D
Deloukas Panos P
Mangino Massimo M
Spector Tim D TD
Zhai Guangju G
Meschia James F JF
Nalls Michael A MA
Sharma Pankaj P
Terzic Janos J
Kumar M J Kranthi MJ
Denniff Matthew M
Zukowska-Szczechowska Ewa E
Wagenknecht Lynne E LE
Fowkes F Gerald R FG
Charchar Fadi J FJ
Schwarz Peter E H PE
Hayward Caroline C
Guo Xiuqing X
Rotimi Charles C
Bots Michiel L ML
Brand Eva E
Samani Nilesh J NJ
Polasek Ozren O
Talmud Philippa J PJ
Nyberg Fredrik F
Kuh Diana D
Laan Maris M
Hveem Kristian K
Palmer Lyle J LJ
van der Schouw Yvonne T YT
Casas Juan P JP
Mohlke Karen L KL
Vineis Paolo P
Raitakari Olli O
Ganesh Santhi K SK
Wong Tien Y TY
Tai E Shyong ES
Cooper Richard S RS
Laakso Markku M
Rao Dabeeru C DC
Harris Tamara B TB
Morris Richard W RW
Dominiczak Anna F AF
Kivimaki Mika M
Marmot Michael G MG
Miki Tetsuro T
Saleheen Danish D
Chandak Giriraj R GR
Coresh Josef J
Navis Gerjan G
Salomaa Veikko V
Han Bok-Ghee BG
Zhu Xiaofeng X
Kooner Jaspal S JS
Melander Olle O
Ridker Paul M PM
Bandinelli Stefania S
Gyllensten Ulf B UB
Wright Alan F AF
Wilson James F JF
Ferrucci Luigi L
Farrall Martin M
Tuomilehto Jaakko J
Pramstaller Peter P PP
Elosua Roberto R
Soranzo Nicole N
Sijbrands Eric J G EJ
Altshuler David D
Loos Ruth J F RJ
Shuldiner Alan R AR
Gieger Christian C
Meneton Pierre P
Uitterlinden Andre G AG
Wareham Nicholas J NJ
Gudnason Vilmundur V
Rotter Jerome I JI
Rettig Rainer R
Uda Manuela M
Strachan David P DP
Witteman Jacqueline C M JC
Hartikainen Anna-Liisa AL
Beckmann Jacques S JS
Boerwinkle Eric E
Vasan Ramachandran S RS
Boehnke Michael M
Larson Martin G MG
Jarvelin Marjo-Riitta MR
Psaty Bruce M BM
Abecasis Goncalo R GR
Chakravarti Aravinda A
Elliott Paul P
van Duijn Cornelia M CM
Newton-Cheh Christopher C
Levy Daniel D
Caulfield Mark J MJ
Johnson Toby T
Dupuis J J
Langenberg C C
Prokopenko I I
Saxena R R
Soranzo N N
Jackson A U AU
Wheeler E E
Glazer N L NL
Bouatia-Naji N N
Gloyn A L AL
Lindgren C M CM
Mägi R R
Morris A P AP
Randall J J
Johnson T T
Elliott P P
Rybin D D
Thorleifsson G G
Steinthorsdottir V V
Henneman P P
Grallert H H
Dehghan A A
Hottenga J J JJ
Franklin C S CS
Navarro P P
Song K K
Goel A A
Perry J R JR
Egan J M JM
Lajunen T T
Grarup N N
Sparsø T T
Doney A A
Voight B F BF
Stringham H M HM
Li M M
Kanoni S S
Shrader P P
Cavalcanti-Proença C C
Kumari M M
Qi L L
Timpson N J NJ
Gieger C C
Zabena C C
Rocheleau G G
Ingelsson E E
An P P
O'Connell J J
Luan J J
Elliott A A
McCarroll S A SA
Payne F F
Roccasecca R M RM
Pattou F F
Sethupathy P P
Ardlie K K
Ariyurek Y Y
Balkau B B
Barter P P
Beilby J P JP
Ben-Shlomo Y Y
Benediktsson R R
Bennett A J AJ
Bergmann S S
Bochud M M
Boerwinkle E E
Bonnefond A A
Bonnycastle L L LL
Borch-Johnsen K K
Böttcher Y Y
Brunner E E
Bumpstead S J SJ
Charpentier G G
Chen Y D YD
Chines P P
Clarke R R
Coin L J LJ
Cooper M N MN
Cornelis M M
Crawford G G
Crisponi L L
Day I N IN
de Geus E J EJ
Delplanque J J
Dina C C
Erdos M R MR
Fedson A C AC
Fischer-Rosinsky A A
Forouhi N G NG
Fox C S CS
Frants R R
Franzosi M G MG
Galan P P
Goodarzi M O MO
Graessler J J
Groves C J CJ
Grundy S S
Gwilliam R R
Gyllensten U U
Hadjadj S S
Hallmans G G
Hammond N N
Han X X
Hartikainen A L AL
Hassanali N N
Hayward C C
Heath S C SC
Hercberg S S
Herder C C
Hicks A A AA
Hillman D R DR
Hingorani A D AD
Hofman A A
Hui J J
Hung J J
Isomaa B B
Johnson P R PR
Jørgensen T T
Jula A A
Kaakinen M M
Kaprio J J
Kesaniemi Y A YA
Kivimaki M M
Knight B B
Koskinen S S
Kovacs P P
Kyvik K O KO
Lathrop G M GM
Lawlor D A DA
Le Bacquer O O
Lecoeur C C
Li Y Y
Lyssenko V V
Mahley R R
Mangino M M
Manning A K AK
Martínez-Larrad M T MT
McAteer J B JB
McCulloch L J LJ
McPherson R R
Meisinger C C
Melzer D D
Meyre D D
Mitchell B D BD
Morken M A MA
Mukherjee S S
Naitza S S
Narisu N N
Neville M J MJ
Oostra B A BA
Orrù M M
Pakyz R R
Palmer C N CN
Paolisso G G
Pattaro C C
Pearson D D
Peden J F JF
Pedersen N L NL
Perola M M
Pfeiffer A F AF
Pichler I I
Polasek O O
Posthuma D D
Potter S C SC
Pouta A A
Province M A MA
Psaty B M BM
Rathmann W W
Rayner N W NW
Rice K K
Ripatti S S
Rivadeneira F F
Roden M M
Rolandsson O O
Sandbaek A A
Sandhu M M
Sanna S S
Sayer A A AA
Scheet P P
Scott L J LJ
Seedorf U U
Sharp S J SJ
Shields B B
Sigurethsson G G
Sijbrands E J EJ
Silveira A A
Simpson L L
Singleton A A
Smith N L NL
Sovio U U
Swift A A
Syddall H H
Syvänen A C AC
Tanaka T T
Thorand B B
Tichet J J
Tönjes A A
Tuomi T T
Uitterlinden A G AG
van Dijk K W KW
van Hoek M M
Varma D D
Visvikis-Siest S S
Vitart V V
Vogelzangs N N
Waeber G G
Wagner P J PJ
Walley A A
Walters G B GB
Ward K L KL
Watkins H H
Weedon M N MN
Wild S H SH
Willemsen G G
Witteman J C JC
Yarnell J W JW
Zeggini E E
Zelenika D D
Zethelius B B
Zhai G G
Zhao J H JH
Zillikens M C MC
Borecki I B IB
Loos R J RJ
Meneton P P
Magnusson P K PK
Nathan D M DM
Williams G H GH
Hattersley A T AT
Silander K K
Salomaa V V
Smith G D GD
Bornstein S R SR
Schwarz P P
Spranger J J
Karpe F F
Shuldiner A R AR
Cooper C C
Dedoussis G V GV
Serrano-Ríos M M
Morris A D AD
Lind L L
Palmer L J LJ
Hu F B FB
Franks P W PW
Ebrahim S S
Marmot M M
Kao W H WH
Pankow J S JS
Sampson M J MJ
Kuusisto J J
Laakso M M
Hansen T T
Pedersen O O
Pramstaller P P PP
Wichmann H E HE
Illig T T
Rudan I I
Wright A F AF
Stumvoll M M
Campbell H H
Wilson J F JF
Hamsten Anders A
Bergman R N RN
Buchanan T A TA
Collins F S FS
Mohlke K L KL
Tuomilehto J J
Valle T T TT
Altshuler D D
Rotter J I JI
Siscovick D S DS
Penninx B W BW
Boomsma D I DI
Deloukas P P
Spector T D TD
Frayling T M TM
Ferrucci L L
Kong A A
Thorsteinsdottir U U
Stefansson K K
van Duijn C M CM
Aulchenko Y S YS
Cao A A
Scuteri A A
Schlessinger D D
Uda M M
Ruokonen A A
Jarvelin M R MR
Waterworth D M DM
Vollenweider P P
Peltonen L L
Mooser V V
Abecasis G R GR
Wareham N J NJ
Sladek R R
Froguel P P
Watanabe R M RM
Meigs J B JB
Groop L L
Boehnke M M
McCarthy M I MI
Florez J C JC
Barroso
JOURNAL
VOLUME: 43
ISSUE: 11
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2011
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites PLoS Genet. 2009 Jun;5(6):e1000534 19557189
Cites JAMA. 2009 Jul 1;302(1):37-48 19567438
Cites Analyst. 2009 Sep;134(9):1781-5 19684899
Cites Diabetes. 2009 Sep;58(9):2027-31 19581420
Cites Eur J Epidemiol. 2009;24(9):553-72 19728115
Cites Nature. 2009 Dec 17;462(7275):868-74 20016592
Cites Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7119-24 21471458
Cites Nat Genet. 2010 Feb;42(2):137-41 20037589
Cites Nat Genet. 2010 Feb;42(2):105-16 20081858
Cites Hepatology. 2010 Feb;51(2):595-602 20014114
Cites J Biol Chem. 2010 Feb 26;285(9):6706-15 20034933
Cites Nat Genet. 2010 Mar;42(3):210-5 20139978
Cites BMC Public Health. 2010;10(1):144 20298560
Cites Nat Genet. 2010 May;42(5):373-5 20383145
Cites Nat Genet. 2010 Jul;42(7):579-89 20581827
Cites Nature. 2010 Aug 5;466(7307):707-13 20686565
Cites Nat Genet. 2009 Jun;41(6):677-87 19430479
Cites Nat Genet. 2009 Jun;41(6):666-76 19430483
Cites Nat Genet. 2010 Nov;42(11):937-48 20935630
Cites Nature. 2010 Oct 28;467(7319):1061-73 20981092
Cites Am J Epidemiol. 2010 Dec 1;172(11):1280-5 20937632
Cites J Clin Endocrinol Metab. 2010 Dec;95(12):E430-6 20826584
Cites Cancer Epidemiol Biomarkers Prev. 2010 Dec;19(12):3140-9 20971884
Cites Mol Syst Biol. 2010 Dec 21;6:441 21179014
Cites Mol Biosyst. 2011 Feb;7(2):385-93 21057674
Cites PLoS Genet. 2011 Mar;7(3):e1001324 21423719
Cites J Clin Psychiatry. 2011 Mar;72(3):341-8 21294994
Cites N Engl J Med. 2009 Dec 24;361(26):2518-28 20032323
Cites N Engl J Med. 2000 Apr 27;342(17):1266-71 10781624
Cites J Cell Biol. 2000 Sep 4;150(5):1101-12 10973998
Cites Gastroenterology. 2002 Nov;123(5):1659-66 12404240
Cites Twin Res. 2002 Oct;5(5):440-3 12537873
Cites Nat Med. 2003 May;9(5):548-53 12692541
Cites Biochem J. 2004 May 15;380(Pt 1):75-81 14967068
Cites Hepatology. 2004 Jul;40(1):27-38 15239083
Cites Gastroenterology. 2004 Aug;127(2):379-84 15300568
Cites Diabetes. 2004 Nov;53(11):2855-60 15504965
Cites Am J Gastroenterol. 1992 Aug;87(8):991-5 1353662
Cites Psychol Med. 1997 Nov;27(6):1381-96 9403910
Cites Nat Genet. 1998 Mar;18(3):219-24 9500542
Cites Mamm Genome. 1998 Sep;9(9):710-4 9716655
Cites Toxicol Pathol. 2005;33(1):1-5 15805049
Cites Gesundheitswesen. 2005 Aug;67 Suppl 1:S13-8 16032512
Cites Methods Enzymol. 2005;401:468-83 16399403
Cites Hepatology. 2006 May;43(5):1145-51 16628637
Cites Hepatology. 2006 Jul;44(1):195-204 16799980
Cites Nat Genet. 2006 Aug;38(8):904-9 16862161
Cites Hepatology. 2006 Aug;44(2):478-86 16871584
Cites Ann Hum Genet. 2006 Sep;70(Pt 5):587-93 16907705
Cites Curr Drug Metab. 2006 Aug;7(6):613-28 16918316
Cites Twin Res Hum Genet. 2006 Dec;9(6):772-7 17254406
Cites Twin Res Hum Genet. 2006 Dec;9(6):849-57 17254420
Cites Science. 2007 Jun 1;316(5829):1331-6 17463246
Cites Nat Clin Pract Gastroenterol Hepatol. 2007 Aug;4(8):432-41 17667992
Cites Nat Genet. 2007 Oct;39(10):1202-7 17873877
Cites Nature. 2007 Oct 18;449(7164):851-61 17943122
Cites Am J Hum Genet. 2008 Jan;82(1):139-49 18179892
Cites Eur J Epidemiol. 2008;23(1):67-74 18075776
Cites Proteins. 2008 Feb 15;70(3):611-25 17876813
Cites Nature. 2008 Mar 27;452(7186):423-8 18344981
Cites BMC Cardiovasc Disord. 2008;8:6 18366642
Cites PLoS Genet. 2007 Jul;3(7):e115 17658951
Cites Genet Epidemiol. 2008 May;32(4):381-5 18348202
Cites Nat Genet. 2008 May;40(5):638-45 18372903
Cites PLoS Biol. 2008 May 6;6(5):e107 18462017
Cites Nat Genet. 2008 Oct;40(10):1160-2 18776911
Cites Am J Hum Genet. 2008 Oct;83(4):520-8 18940312
Cites PLoS Genet. 2008 Nov;4(11):e1000282 19043545
Cites Nat Genet. 2009 Jan;41(1):35-46 19060910
Cites PLoS One. 2009;4(2):e4435 19209234
Cites Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9362-7 19474294
GRANTS
GRANTID AGENCY COUNTRY
090532 Wellcome Trust United Kingdom
14136 Cancer Research UK United Kingdom
FS/10/011/27881 British Heart Foundation United Kingdom
G0100222 Medical Research Council United Kingdom
G0401527 Medical Research Council United Kingdom
G0601653 Medical Research Council United Kingdom
G0601966 Medical Research Council United Kingdom
G0700342 Medical Research Council United Kingdom
G0700931 Medical Research Council United Kingdom
G0701863 Medical Research Council United Kingdom
G0902037 Medical Research Council United Kingdom
G1000143 Medical Research Council United Kingdom
G19/35 Medical Research Council United Kingdom
G8802774 Medical Research Council United Kingdom
G9521010 Medical Research Council United Kingdom
K05 AA017688 NIAAA NIH HHS United States
MC_PC_U127561128 Medical Research Council United Kingdom
MC_U106179471 Medical Research Council United Kingdom
MC_U106188470 Medical Research Council United Kingdom
MC_U127561128 Medical Research Council United Kingdom
MC_UP_A100_1003 Medical Research Council United Kingdom
MC_UP_A620_1015 Medical Research Council United Kingdom
PG/09/002/26056 British Heart Foundation United Kingdom
PG/09/023/26806 British Heart Foundation United Kingdom
PHCS/C4/4/016 Department of Health United Kingdom
R01 HL087647 NHLBI NIH HHS United States
RG/07/008/23674 British Heart Foundation United Kingdom
Z99 DK999999 Intramural NIH HHS United States
ZIA DK075013-05 Intramural NIH HHS United States
ZIA DK075013-07 Intramural NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Enzymes genetics
Genome-Wide Association Study genetics
Humans genetics
Liver enzymology
Polymorphism, Single Nucleotide enzymology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Enzymes
OTHER ID's
OTHERID SOURCE
NIHMS411128 NLM
PMC3482372 NLM