Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21989516
TITLE
Atopic dermatitis in West Highland white terriers is associated with a 1.3-Mb region on CFA 17.
ABSTRACT
Canine atopic dermatitis (AD) is an allergic inflammatory skin disease that shares similarities with AD in humans. Canine AD is likely to be an inherited disease in dogs and is common in West Highland white terriers (WHWTs). We performed a genome-wide association study using the Affymetrix Canine SNP V2 array consisting of over 42,800 single nucleotide polymorphisms, on 35 atopic and 25 non-atopic WHWTs. A gene-dropping simulation method, using SIB-PAIR, identified a projected 1.3 Mb area of association (genome-wide P = 6 × 10(-5) to P = 7 × 10(-4)) on CFA 17. Nineteen genes on CFA 17, including 1 potential candidate gene (PTPN22), were located less than 0.5 Mb from the interval of association identified on the genome-wide association analysis. Four haplotypes within this locus were differently distributed between cases and controls in this population of dogs. These findings suggest that a major locus for canine AD in WHWTs may be located on, or in close proximity to an area on CFA 17.
DATE PUBLISHED
2012 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2011/02/16
accepted 2011/09/21
aheadofprint 2011/10/12
entrez 2011/10/13 06:00
pubmed 2011/10/13 06:00
medline 2012/04/10 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Roque JB Roque Joana B JB School of Veterinary Science, The University of Queensland, 4343, Gatton, QLD, Australia.
O'Leary CA O'Leary Caroline A CA
Duffy DL Duffy David L DL
Kyaw-Tanner M Kyaw-Tanner Myat M
Gharahkhani P Gharahkhani Puya P
Vogelnest L Vogelnest Linda L
Mason K Mason Kenneth K
Shipstone M Shipstone Michael M
Latter M Latter Melanie M
INVESTIGATORS
JOURNAL
VOLUME: 64
ISSUE: 3
TITLE: Immunogenetics
ISOABBREVIATION: Immunogenetics
YEAR: 2012
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1432-1211
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Immunogenetics
COUNTRY: United States
ISSNLINKING: 0093-7711
NLMUNIQUEID: 0420404
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Animals
Chromosome Mapping
Dermatitis, Atopic veterinary
Dog Diseases immunology
Dogs immunology
Genetic Loci immunology
Genome-Wide Association Study immunology
Genotype immunology
Polymorphism, Single Nucleotide immunology
Protein Tyrosine Phosphatase, Non-Receptor Type 22 genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
EC 3.1.3.48 Protein Tyrosine Phosphatase, Non-Receptor Type 22
OTHER ID's