Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
2184094
TITLE
Using factor scores to detect G X E interactive origin of "pure" genetic or environmental factors obtained in genetic covariance structure analysis.
ABSTRACT
Moment expressions for individual factor scores can serve as simple tests for the presence of a particular class of interaction factors that are disguised as pure genetic and/or environmental factors. That is, individual genetic and environmental factor scores may be used to construct fourth-order moments of these factors in order to test whether a common genetic or environmental factor in the multivariate genetic factor model is in fact of the interactive origin concerned. Expected fourth-order moments are derived for cases with and without interaction. Application of fourth-order moments of factor scores to detect interactive origin of common factors is illustrated with simulated twin data.
DATE PUBLISHED
1990
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1990/01/01
medline 1990/01/01 00:01
entrez 1990/01/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Molenaar PC Molenaar P C PC Department of Psychology, University of Amsterdam, The Netherlands.
Boomsma DI Boomsma D I DI
Neeleman D Neeleman D D
Dolan CV Dolan C V CV
INVESTIGATORS
JOURNAL
VOLUME: 7
ISSUE: 1
TITLE: Genetic epidemiology
ISOABBREVIATION: Genet. Epidemiol.
YEAR: 1990
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0741-0395
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Genet Epidemiol
COUNTRY: United States
ISSNLINKING: 0741-0395
NLMUNIQUEID: 8411723
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Environment
Genetic Techniques
Genetic Variation genetics
Genotype genetics
Mathematics genetics
Models, Genetic genetics
Multivariate Analysis genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's