Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
2184093
TITLE
Estimation of individual genetic and environmental factor scores.
ABSTRACT
Implicit in the application of the common-factor model as a method for decomposing trait covariance into a genetic and environmental part is the use of factor scores. In multivariate analyses, it is possible to estimate these factor scores for the communal part of the model. Estimation of scores on latent factors in terms of individual observations within the context of a twin/family study amounts to estimation of individual genetic and environmental scores. Such estimates may be of both theoretical and practical interest and may be provided with confidence intervals around the individual estimates. The method is first illustrated with stimulated twin data and next is applied to blood pressure data obtained in a Dutch sample of 59 male adolescent twin pairs. Subjects with high blood pressure can be distinguished into groups with high genetic or high environmental scores.
DATE PUBLISHED
1990
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1990/01/01
medline 1990/01/01 00:01
entrez 1990/01/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Boomsma DI Boomsma D I DI Department of Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Molenaar PC Molenaar P C PC
Orlebeke JF Orlebeke J F JF
INVESTIGATORS
JOURNAL
VOLUME: 7
ISSUE: 1
TITLE: Genetic epidemiology
ISOABBREVIATION: Genet. Epidemiol.
YEAR: 1990
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0741-0395
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Genet Epidemiol
COUNTRY: United States
ISSNLINKING: 0741-0395
NLMUNIQUEID: 8411723
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Blood Pressure genetics
Computer Simulation genetics
Confidence Intervals genetics
Environment genetics
Factor Analysis, Statistical genetics
Genetic Techniques genetics
Genetic Variation genetics
Humans genetics
Male genetics
Mathematics genetics
Models, Genetic genetics
Multivariate Analysis genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's