Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21121932
TITLE
Relationship between type 1 diabetes and atopic diseases in a twin population.
ABSTRACT
AIM NlmCategory: OBJECTIVE
To study the association between type 1 diabetes and atopic diseases in a twin population.
METHODS NlmCategory: METHODS
We performed record linkage between questionnaire-defined atopic dermatitis, asthma and hay fever, and hospital discharge diagnoses of type 1 diabetes in 54,530 Danish twins, 3-71 years of age.
RESULTS NlmCategory: RESULTS
The age- and sex-adjusted risk of atopic dermatitis was decreased in subjects with type 1 diabetes compared with nondiabetic subjects, (2.1%vs 9.9%), odds ratio (OR)= 0.23 (0.07-0.71), P = 0.011, whereas asthma and hay fever were not significantly associated with type 1 diabetes. Within twin pairs discordant for type 1 diabetes, the diabetic twin had a lower risk of atopic dermatitis relative to the nondiabetic co-twin. Genetic factors for atopic dermatitis and type 1 diabetes were negatively correlated (r = -0.30), P = 0.0009.
CONCLUSIONS NlmCategory: CONCLUSIONS
These findings substantiate the Th1 vs Th2 cell dichotomy for type 1 diabetes and atopic dermatitis, and indicate an inverse association between genetic factors for these disorders.
2010 John Wiley & Sons A/S.
DATE PUBLISHED
2011 May
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2010/12/01
entrez 2010/12/03 06:00
pubmed 2010/12/03 06:00
medline 2011/08/09 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Thomsen SF Thomsen S F SF Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark. sft@city.dk
Duffy DL Duffy D L DL
Kyvik KO Kyvik K O KO
Skytthe A Skytthe A A
Backer V Backer V V
INVESTIGATORS
JOURNAL
VOLUME: 66
ISSUE: 5
TITLE: Allergy
ISOABBREVIATION: Allergy
YEAR: 2011
MONTH: May
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1398-9995
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Allergy
COUNTRY: Denmark
ISSNLINKING: 0105-4538
NLMUNIQUEID: 7804028
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
CommentIn Allergy. 2011 Dec;66(12):1612-3; author reply 1613-4 21797884
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Asthma
Child
Child, Preschool
Dermatitis, Atopic etiology
Diabetes Mellitus, Type 1 genetics
Female genetics
Humans genetics
Male genetics
Middle Aged genetics
Odds Ratio genetics
Rhinitis, Allergic, Seasonal genetics
Th1 Cells genetics
Th2 Cells genetics
Twins genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's