Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21083567
TITLE
Risk of asthma in adult twins with type 2 diabetes and increased body mass index.
ABSTRACT
AIM NlmCategory: OBJECTIVE
To examine the relationship between asthma, type 2 diabetes and increased body mass index (BMI) in adult twins.
METHODS NlmCategory: METHODS
We performed record linkage between questionnaire-defined asthma and BMI, and hospital discharge diagnoses of type 2 diabetes in 34,782 Danish twins, 20-71 years of age.
RESULTS NlmCategory: RESULTS
The risk of asthma was increased in subjects with type 2 diabetes relative to nondiabetic subjects both in men (13.5%vs 7.5%), P = 0.001 and in women (16.6%vs 9.6%), P = 0.001. The result remained significant after adjustment for age, BMI, smoking, symptoms of chronic bronchitis, marital status and zygosity, men: OR = 1.70 (1.07-2.70), P = 0.026; women: OR = 1.88 (1.24-2.85), P = 0.003. In this analysis, BMI remained a highly significant predictor for asthma independently of diabetes status in women, P < 0.000 but not in men, P = 0.336. Significant positive genetic correlations were found between asthma and type 2 diabetes, 0.20 (0.01-0.40), P = 0.047; between asthma and BMI in women, 0.15 (0.07-0.22), P < 0.000; and between BMI and type 2 diabetes, 0.40 (0.29-0.43), P < 0.000.
CONCLUSIONS NlmCategory: CONCLUSIONS
Asthma, type 2 diabetes and increased BMI are strongly associated in adults, particularly in women. These results suggest a common aetiology for asthma and metabolic syndrome.
2010 John Wiley & Sons A/S.
DATE PUBLISHED
2011 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2010/11/17
entrez 2010/11/19 06:00
pubmed 2010/11/19 06:00
medline 2011/07/21 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Thomsen SF Thomsen S F SF Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark. sft@city.dk
Duffy DL Duffy D L DL
Kyvik KO Kyvik K O KO
Skytthe A Skytthe A A
Backer V Backer V V
INVESTIGATORS
JOURNAL
VOLUME: 66
ISSUE: 4
TITLE: Allergy
ISOABBREVIATION: Allergy
YEAR: 2011
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1398-9995
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Allergy
COUNTRY: Denmark
ISSNLINKING: 0105-4538
NLMUNIQUEID: 7804028
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Asthma etiology
Body Mass Index etiology
Diabetes Mellitus, Type 2 complications
Diseases in Twins immunology
Female immunology
Humans immunology
Male immunology
Middle Aged immunology
Risk Factors immunology
Twins immunology
Young Adult immunology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's