Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
20673982
TITLE
Genetic influence on the age at onset of asthma: a twin study.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Although the genetics of asthma susceptibility have been frequently explored, little is known about genetic factors that influence the age at onset of asthma.
OBJECTIVE NlmCategory: OBJECTIVE
To study the variation in the age at onset of asthma attributable to genetic and environmental factors.
METHODS NlmCategory: METHODS
Data on the age at onset and predictors of asthma were collected in 2002 via a multidisciplinary questionnaire study of 34,782 Danish twins 20 to 71 years of age. Survival analytic methods were applied to partition variation in the age at onset of asthma into genetic and environmental components.
RESULTS NlmCategory: RESULTS
Sex, hay fever, atopic dermatitis, smoking, and exposure to passive smoking in childhood were significant risk factors, whereas BCG vaccination was protective for asthma. The risk of asthma in the co-twin of an affected twin was higher in monozygotic than in dizygotic twins (hazard ratio, 2.59; 95% CI, 1.83-3.68; P < .001). The risk of asthma in the co-twin decreased with increasing age at onset of asthma in the index twin (hazard ratio per ten years, 0.86; 95% CI, 0.76-0.98; P = .019). The effect was attenuated in dizygotic twins relative to monozygotic twins (P = .005). Genetic factors explained 34% of the variation in the age at onset of asthma, and environmental factors accounted for 66%.
CONCLUSION NlmCategory: CONCLUSIONS
Host-related differences in genetic makeup cause different individuals to develop asthma at different ages. Better understanding of the causes for variation in the age at onset of disease may ultimately lead the way to targeted treatments.
Copyright (c) 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
DATE PUBLISHED
2010 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2010/01/14
revised 2010/04/30
accepted 2010/06/04
aheadofprint 2010/07/31
entrez 2010/08/03 06:00
pubmed 2010/08/03 06:00
medline 2010/09/30 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Thomsen SF Thomsen Simon Francis SF Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark. sft@city.dk
Duffy DL Duffy David Lorenzo DL
Kyvik KO Kyvik Kirsten Ohm KO
Backer V Backer Vibeke V
INVESTIGATORS
JOURNAL
VOLUME: 126
ISSUE: 3
TITLE: The Journal of allergy and clinical immunology
ISOABBREVIATION: J. Allergy Clin. Immunol.
YEAR: 2010
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1097-6825
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Allergy Clin Immunol
COUNTRY: United States
ISSNLINKING: 0091-6749
NLMUNIQUEID: 1275002
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age of Onset
Aged
Asthma genetics
Denmark epidemiology
Environment epidemiology
Female epidemiology
Genetic Predisposition to Disease epidemiology
Humans epidemiology
Male epidemiology
Middle Aged epidemiology
Questionnaires epidemiology
Regression Analysis epidemiology
Risk Factors epidemiology
Young Adult epidemiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's