Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
18824185
TITLE
Genetic influences on handedness: data from 25,732 Australian and Dutch twin families.
ABSTRACT
Handedness refers to a consistent asymmetry in skill or preferential use between the hands and is related to lateralization within the brain of other functions such as language. Previous twin studies of handedness have yielded inconsistent results resulting from a general lack of statistical power to find significant effects. Here we present analyses from a large international collaborative study of handedness (assessed by writing/drawing or self report) in Australian and Dutch twins and their siblings (54,270 individuals from 25,732 families). Maximum likelihood analyses incorporating the effects of known covariates (sex, year of birth and birth weight) revealed no evidence of hormonal transfer, mirror imaging or twin specific effects. There were also no differences in prevalence between zygosity groups or between twins and their singleton siblings. Consistent with previous meta-analyses, additive genetic effects accounted for about a quarter (23.64%) of the variance (95%CI 20.17, 27.09%) with the remainder accounted for by non-shared environmental influences. The implications of these findings for handedness both as a primary phenotype and as a covariate in linkage and association analyses are discussed.
DATE PUBLISHED
2009 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2008/05/24
revised 2008/08/12
accepted 2008/09/02
aheadofprint 2008/09/09
pubmed 2008/10/01 09:00
medline 2009/04/14 09:00
entrez 2008/10/01 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Medland SE Medland Sarah E SE Queensland Institute of Medical Research, Australia. sarahMe@qimr.edu.au
Duffy DL Duffy David L DL
Wright MJ Wright Margaret J MJ
Geffen GM Geffen Gina M GM
Hay DA Hay David A DA
Levy F Levy Florence F
van-Beijsterveldt CE van-Beijsterveldt Catherina E M CE
Willemsen G Willemsen Gonneke G
Townsend GC Townsend Grant C GC
White V White Vicki V
Hewitt AW Hewitt Alex W AW
Mackey DA Mackey David A DA
Bailey JM Bailey J Michael JM
Slutske WS Slutske Wendy S WS
Nyholt DR Nyholt Dale R DR
Treloar SA Treloar Susan A SA
Martin NG Martin Nicholas G NG
Boomsma DI Boomsma Dorret I DI
INVESTIGATORS
JOURNAL
VOLUME: 47
ISSUE: 2
TITLE: Neuropsychologia
ISOABBREVIATION: Neuropsychologia
YEAR: 2009
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0028-3932
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Neuropsychologia
COUNTRY: England
ISSNLINKING: 0028-3932
NLMUNIQUEID: 0020713
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Cortex. 1992 Sep;28(3):373-81 1395641
Cites Neuropsychologia. 1998 Jun;36(6):531-4 9705063
Cites Behav Genet. 1994 May;24(3):239-58 7945154
Cites Epidemiology. 2000 Sep;11(5):576-80 10955411
Cites Behav Genet. 2000 Jul;30(4):345-56 11206089
Cites Schizophr Res. 2001 Jul 1;50(3):181-9 11439239
Cites Twin Res. 2001 Feb;4(1):48-56 11665325
Cites Am J Hum Genet. 2002 Mar;70(3):800-5 11774074
Cites Schizophr Bull. 1999;25(1):63-78 10098914
Cites Neurology. 1999 Mar 23;52(5):1038-43 10102425
Cites Neuroreport. 1999 Feb 5;10(2):333-6 10203331
Cites Schizophr Res. 1999 Oct 19;39(3):167-76 10507509
Cites Schizophr Res. 1999 Oct 19;39(3):207-18 10507513
Cites Neuropsychologia. 2005;43(3):313-5 15707608
Cites Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3718-22 16186354
Cites Behav Brain Sci. 2005 Aug;28(4):575-89; discussion 589-633 16209828
Cites Behav Genet. 2005 Nov;35(6):735-44 16273319
Cites Twin Res Hum Genet. 2006 Feb;9(1):46-53 16611467
Cites Laterality. 2006 Nov;11(6):508-24 16966240
Cites Twin Res Hum Genet. 2006 Dec;9(6):718-26 17254397
Cites Mol Psychiatry. 2007 Dec;12(12):1129-39, 1057 17667961
Cites Ultrasound Obstet Gynecol. 2002 Mar;19(3):217-21 11896939
Cites Twin Res. 2002 Apr;5(2):98-106 11931687
Cites Br J Psychiatry. 2002 Oct;181:295-7 12356655
Cites Eur J Hum Genet. 2002 Oct;10(10):623-30 12357333
Cites Am J Hum Genet. 2003 Feb;72(2):499-502 12596796
Cites Twin Res. 2002 Oct;5(5):401-6 12537867
Cites Twin Res. 2003 Apr;6(2):119-30 12723998
Cites Addiction. 2003 Aug;98(8):1087-100 12873243
Cites Aust Dent J. 2003 Jun;48(2):82-8 14649396
Cites Hum Mol Genet. 2003 Dec 15;12(24):3225-30 14583442
Cites J Invest Dermatol. 2003 Dec;121(6):1561-4 14675213
Cites Laterality. 2004 Apr;9(2):175-88 15382716
Cites Neuropsychologia. 1974 Jan;12(1):43-7 4821188
Cites Neuropsychologia. 1973 Jul;11(3):363-6 4792187
Cites J Autism Child Schizophr. 1977 Jun;7(2):177-87 577495
Cites Ann Hum Genet. 1975 Oct;39(2):219-29 1053249
Cites Neuropsychologia. 1980;18(3):347-55 7191061
Cites Percept Mot Skills. 1980 Oct;51(2):666 7192382
Cites Neuropsychologia. 1981;19(3):459-62 7266839
Cites Brain Cogn. 1985 Jan;4(1):27-46 3927944
Cites Psychol Med Monogr Suppl. 1985;8:1-40 3863155
Cites Neuropsychologia. 1986;24(2):301-3 3714038
Cites Behav Genet. 1985 Mar;15(2):93-109 3838073
Cites Behav Genet. 1988 Jan;18(1):69-79 3365198
Cites Nature. 1988 May 19;333(6170):213 3367996
Cites Acta Genet Med Gemellol (Roma). 1990;39(1):109-15 2392887
Cites Behav Genet. 1995 Sep;25(5):433-45 7487840
Cites Dev Med Child Neurol. 1996 Jul;38(7):594-602 8674910
Cites Cortex. 1996 Sep;32(3):479-90 8886523
Cites J Autism Dev Disord. 1996 Dec;26(6):597-609 8986846
Cites Psychol Rev. 1997 Oct;104(4):714-27 9337630
Cites Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):840-5 9517600
Cites Neuropsychologia. 1998 Jan;36(1):37-43 9533385
Cites Behav Genet. 1994 May;24(3):217-27 7945152
GRANTS
GRANTID AGENCY COUNTRY
AA07728 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
DA12854 NIDA NIH HHS United States
MH66206 NIMH NIH HHS United States
R01 MH058799 NIMH NIH HHS United States
R01 MH058799-03 NIMH NIH HHS United States
R01 MH066206 NIMH NIH HHS United States
R01 MH066206-02 NIMH NIH HHS United States
R01 MH066206-03 NIMH NIH HHS United States
R01 MH066206-04 NIMH NIH HHS United States
R01 MH066206-05 NIMH NIH HHS United States
R01 MH58799-03 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Aged, 80 and over
Algorithms
Australia epidemiology
Birth Weight physiology
Child physiology
Cohort Studies physiology
Female physiology
Functional Laterality genetics
Humans genetics
Male genetics
Middle Aged genetics
Models, Statistical genetics
Netherlands epidemiology
Reproducibility of Results epidemiology
Twins epidemiology
Twins, Dizygotic epidemiology
Twins, Monozygotic epidemiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS97478 NLM
PMC2755095 NLM