PMID |
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TITLE |
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Common sequence variants on 20q11.22 confer melanoma susceptibility. |
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ABSTRACT |
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We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2008/03/06 |
accepted |
2008/04/30 |
aheadofprint |
2008/05/18 |
pubmed |
2008/05/20 09:00 |
medline |
2008/07/23 09:00 |
entrez |
2008/05/20 09:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Brown KM |
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Brown |
Kevin M |
KM |
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Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona 85028, USA. |
Macgregor S |
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Macgregor |
Stuart |
S |
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Montgomery GW |
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Montgomery |
Grant W |
GW |
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Craig DW |
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Craig |
David W |
DW |
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Zhao ZZ |
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Zhao |
Zhen Zhen |
ZZ |
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Iyadurai K |
|
Iyadurai |
Kelly |
K |
|
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Henders AK |
|
Henders |
Anjali K |
AK |
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Homer N |
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Homer |
Nils |
N |
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Campbell MJ |
|
Campbell |
Megan J |
MJ |
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Stark M |
|
Stark |
Mitchell |
M |
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Thomas S |
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Thomas |
Shane |
S |
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Schmid H |
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Schmid |
Helen |
H |
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Holland EA |
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Holland |
Elizabeth A |
EA |
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Gillanders EM |
|
Gillanders |
Elizabeth M |
EM |
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Duffy DL |
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Duffy |
David L |
DL |
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Maskiell JA |
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Maskiell |
Judith A |
JA |
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Jetann J |
|
Jetann |
Jodie |
J |
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Ferguson M |
|
Ferguson |
Megan |
M |
|
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Stephan DA |
|
Stephan |
Dietrich A |
DA |
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Cust AE |
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Cust |
Anne E |
AE |
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Whiteman D |
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Whiteman |
David |
D |
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Green A |
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Green |
Adele |
A |
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Olsson H |
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Olsson |
HÃ¥kan |
H |
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Puig S |
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Puig |
Susana |
S |
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Ghiorzo P |
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Ghiorzo |
Paola |
P |
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Hansson J |
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Hansson |
Johan |
J |
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Demenais F |
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Demenais |
Florence |
F |
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Goldstein AM |
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Goldstein |
Alisa M |
AM |
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Gruis NA |
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Gruis |
Nelleke A |
NA |
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Elder DE |
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Elder |
David E |
DE |
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Bishop JN |
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Bishop |
Julia Newton |
JN |
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Kefford RF |
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Kefford |
Richard F |
RF |
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Giles GG |
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Giles |
Graham G |
GG |
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Armstrong BK |
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Armstrong |
Bruce K |
BK |
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Aitken JF |
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Aitken |
Joanne F |
JF |
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Hopper JL |
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Hopper |
John L |
JL |
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Martin NG |
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Martin |
Nicholas G |
NG |
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Trent JM |
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Trent |
Jeffrey M |
JM |
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Mann GJ |
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Mann |
Graham J |
GJ |
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Hayward NK |
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Hayward |
Nicholas K |
NK |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 40 |
ISSUE: 7 |
TITLE: Nature genetics |
ISOABBREVIATION: Nat. Genet. |
YEAR: 2008 |
MONTH: Jul |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1546-1718 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Nat Genet |
COUNTRY: United States |
ISSNLINKING: 1061-4036 |
NLMUNIQUEID: 9216904 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
Research Support, N.I.H., Extramural |
Research Support, Non-U.S. Gov't |
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COMMENTS AND CORRECTIONS |
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REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
Cites |
J Natl Cancer Inst. 2005 Jul 6;97(13):998-1007 |
15998953 |
|
Cites |
Am J Hum Genet. 2000 Jan;66(1):176-86 |
10631149 |
|
Cites |
Am J Hum Genet. 2002 Mar;70(3):770-5 |
11833005 |
|
Cites |
Br J Dermatol. 2004 Feb;150(2):179-85 |
14996086 |
|
Cites |
Hum Genet. 2005 Apr;116(5):402-6 |
15726415 |
|
Cites |
Nucleic Acids Res. 2008 Apr;36(6):e35 |
18276640 |
|
Cites |
J Dermatol Sci. 2005 Nov;40(2):133-6 |
16183259 |
|
Cites |
Cancer Lett. 2005 Dec 18;230(2):153-86 |
16297704 |
|
Cites |
Nucleic Acids Res. 2006;34(7):e55 |
16627870 |
|
Cites |
Pigment Cell Res. 2007 Jun;20(3):216-21 |
17516929 |
|
Cites |
Twin Res Hum Genet. 2008 Apr;11(2):183-96 |
18361720 |
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CommentIn |
Nat Genet. 2008 Jul;40(7):817-8 |
18583973 |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
CA083115 |
NCI NIH HHS |
United States |
CA109544 |
NCI NIH HHS |
United States |
CA83115 |
NCI NIH HHS |
United States |
CA88363 |
NCI NIH HHS |
United States |
HL086528 |
NHLBI NIH HHS |
United States |
R01 CA083115 |
NCI NIH HHS |
United States |
R01 CA083115-08 |
NCI NIH HHS |
United States |
R01 CA088363 |
NCI NIH HHS |
United States |
R01 CA088363-07 |
NCI NIH HHS |
United States |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Adult |
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Age of Onset |
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Case-Control Studies |
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Chromosomes, Human, Pair 20 |
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Genetic Predisposition to Disease |
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Humans |
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Linkage Disequilibrium |
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Melanoma |
genetics |
Odds Ratio |
genetics |
Polymorphism, Single Nucleotide |
genetics |
Skin Neoplasms |
genetics |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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OTHERID |
SOURCE |
NIHMS130202 |
NLM |
PMC2755512 |
NLM |
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