Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18488026
TITLE
Common sequence variants on 20q11.22 confer melanoma susceptibility.
ABSTRACT
We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.
DATE PUBLISHED
2008 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2008/03/06
accepted 2008/04/30
aheadofprint 2008/05/18
pubmed 2008/05/20 09:00
medline 2008/07/23 09:00
entrez 2008/05/20 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Brown KM Brown Kevin M KM Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona 85028, USA.
Macgregor S Macgregor Stuart S
Montgomery GW Montgomery Grant W GW
Craig DW Craig David W DW
Zhao ZZ Zhao Zhen Zhen ZZ
Iyadurai K Iyadurai Kelly K
Henders AK Henders Anjali K AK
Homer N Homer Nils N
Campbell MJ Campbell Megan J MJ
Stark M Stark Mitchell M
Thomas S Thomas Shane S
Schmid H Schmid Helen H
Holland EA Holland Elizabeth A EA
Gillanders EM Gillanders Elizabeth M EM
Duffy DL Duffy David L DL
Maskiell JA Maskiell Judith A JA
Jetann J Jetann Jodie J
Ferguson M Ferguson Megan M
Stephan DA Stephan Dietrich A DA
Cust AE Cust Anne E AE
Whiteman D Whiteman David D
Green A Green Adele A
Olsson H Olsson HÃ¥kan H
Puig S Puig Susana S
Ghiorzo P Ghiorzo Paola P
Hansson J Hansson Johan J
Demenais F Demenais Florence F
Goldstein AM Goldstein Alisa M AM
Gruis NA Gruis Nelleke A NA
Elder DE Elder David E DE
Bishop JN Bishop Julia Newton JN
Kefford RF Kefford Richard F RF
Giles GG Giles Graham G GG
Armstrong BK Armstrong Bruce K BK
Aitken JF Aitken Joanne F JF
Hopper JL Hopper John L JL
Martin NG Martin Nicholas G NG
Trent JM Trent Jeffrey M JM
Mann GJ Mann Graham J GJ
Hayward NK Hayward Nicholas K NK
INVESTIGATORS
JOURNAL
VOLUME: 40
ISSUE: 7
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2008
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites J Natl Cancer Inst. 2005 Jul 6;97(13):998-1007 15998953
Cites Am J Hum Genet. 2000 Jan;66(1):176-86 10631149
Cites Am J Hum Genet. 2002 Mar;70(3):770-5 11833005
Cites Br J Dermatol. 2004 Feb;150(2):179-85 14996086
Cites Hum Genet. 2005 Apr;116(5):402-6 15726415
Cites Nucleic Acids Res. 2008 Apr;36(6):e35 18276640
Cites J Dermatol Sci. 2005 Nov;40(2):133-6 16183259
Cites Cancer Lett. 2005 Dec 18;230(2):153-86 16297704
Cites Nucleic Acids Res. 2006;34(7):e55 16627870
Cites Pigment Cell Res. 2007 Jun;20(3):216-21 17516929
Cites Twin Res Hum Genet. 2008 Apr;11(2):183-96 18361720
CommentIn Nat Genet. 2008 Jul;40(7):817-8 18583973
GRANTS
GRANTID AGENCY COUNTRY
CA083115 NCI NIH HHS United States
CA109544 NCI NIH HHS United States
CA83115 NCI NIH HHS United States
CA88363 NCI NIH HHS United States
HL086528 NHLBI NIH HHS United States
R01 CA083115 NCI NIH HHS United States
R01 CA083115-08 NCI NIH HHS United States
R01 CA088363 NCI NIH HHS United States
R01 CA088363-07 NCI NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age of Onset
Case-Control Studies
Chromosomes, Human, Pair 20
Genetic Predisposition to Disease
Humans
Linkage Disequilibrium
Melanoma genetics
Odds Ratio genetics
Polymorphism, Single Nucleotide genetics
Skin Neoplasms genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS130202 NLM
PMC2755512 NLM