Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18361720
TITLE
The Queensland Study of Melanoma: environmental and genetic associations (Q-MEGA); study design, baseline characteristics, and repeatability of phenotype and sun exposure measures.
ABSTRACT
Cutaneous malignant melanoma (CMM) is a major health issue in Queensland, Australia, which has the world's highest incidence. Recent molecular and epidemiologic studies suggest that CMM arises through multiple etiological pathways involving gene-environment interactions. Understanding the potential mechanisms leading to CMM requires larger studies than those previously conducted. This article describes the design and baseline characteristics of Q-MEGA, the Queensland Study of Melanoma: Environmental and Genetic Associations, which followed up 4 population-based samples of CMM patients in Queensland, including children, adolescents, men aged over 50, and a large sample of adult cases and their families, including twins. Q-MEGA aims to investigate the roles of genetic and environmental factors, and their interaction, in the etiology of melanoma. Three thousand, four hundred and seventy-one participants took part in the follow-up study and were administered a computer-assisted telephone interview in 2002-2005. Updated data on environmental and phenotypic risk factors, and 2777 blood samples were collected from interviewed participants as well as a subset of relatives. This study provides a large and well-described population-based sample of CMM cases with follow-up data. Characteristics of the cases and repeatability of sun exposure and phenotype measures between the baseline and the follow-up surveys, from 6 to 17 years later, are also described.
DATE PUBLISHED
2008 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2008/03/26 09:00
medline 2008/09/05 09:00
entrez 2008/03/26 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Baxter AJ Baxter Amanda J AJ Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Hughes MC Hughes Maria Celia MC
Kvaskoff M Kvaskoff Marina M
Siskind V Siskind Victor V
Shekar S Shekar Sri S
Aitken JF Aitken Joanne F JF
Green AC Green Adele C AC
Duffy DL Duffy David L DL
Hayward NK Hayward Nicholas K NK
Martin NG Martin Nicholas G NG
Whiteman DC Whiteman David C DC
INVESTIGATORS
JOURNAL
VOLUME: 11
ISSUE: 2
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2008
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
CA88363 NCI NIH HHS United States
R01 CA088363 NCI NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Child
Data Interpretation, Statistical
Female
Genetic Predisposition to Disease
Humans
Incidence
Male
Melanoma genetics
Middle Aged genetics
Queensland epidemiology
Questionnaires epidemiology
Reproducibility of Results epidemiology
Research Design epidemiology
Risk Factors epidemiology
Skin Neoplasms genetics
Sunlight adverse effects
Twin Studies as Topic adverse effects
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS468849 NLM
PMC3677021 NLM