Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
18319743
TITLE
Heritability in the genomics era--concepts and misconceptions.
ABSTRACT
Heritability allows a comparison of the relative importance of genes and environment to the variation of traits within and across populations. The concept of heritability and its definition as an estimable, dimensionless population parameter was introduced by Sewall Wright and Ronald Fisher nearly a century ago. Despite continuous misunderstandings and controversies over its use and application, heritability remains key to the response to selection in evolutionary biology and agriculture, and to the prediction of disease risk in medicine. Recent reports of substantial heritability for gene expression and new estimation methods using marker data highlight the relevance of heritability in the genomics era.
DATE PUBLISHED
2008 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2008/03/04
pubmed 2008/03/06 09:00
medline 2008/03/28 09:00
entrez 2008/03/06 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Visscher PM Visscher Peter M PM Queensland Institute of Medical Research, Royal Brisbane Hospital Post Office, Brisbane 4029, Queensland, Australia. Peter.Visscher@qimr.edu.au
Hill WG Hill William G WG
Wray NR Wray Naomi R NR
INVESTIGATORS
JOURNAL
VOLUME: 9
ISSUE: 4
TITLE: Nature reviews. Genetics
ISOABBREVIATION: Nat. Rev. Genet.
YEAR: 2008
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1471-0064
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Rev Genet
COUNTRY: England
ISSNLINKING: 1471-0056
NLMUNIQUEID: 100962779
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Review
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Analysis of Variance
Animals
Bayes Theorem
Biological Evolution
Female
Gene Expression
Genomics
Humans
Inbreeding
Linear Models
Male
Models, Genetic
Phenotype
Quantitative Trait, Heritable
Regression Analysis
Selection, Genetic
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's