Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
17903117
TITLE
A longitudinal genetic study of uric acid and liver enzymes in adolescent twins.
ABSTRACT
Biochemical traits such as plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyltransferase (GGT) and uric acid are associated with obesity, and with risk of cardiovascular disease, metabolic syndrome and diabetes. Each is subject to genetic influences, but little is known about changes in genetic and environmental influences on these traits over time. We investigated the contribution of genetic and environmental influences to variation in these biochemical traits in adolescent twins and their nontwin siblings from 965 twin families. Twins were studied at ages 12, 14 and 16 years. Multivariate genetic models that included effects of age and sex were fitted to determine whether the same or different genetic or environmental factors influence each trait at different ages. Results showed that the genetic factors influencing AST, ALT, GGT and uric acid change over time during adolescence, and that the magnitude of these effects differs between males and females. The nonshared environment effects were generally time specific. There are developmental changes in genes affecting these traits during adolescence.
DATE PUBLISHED
2007 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2007/10/02 09:00
medline 2008/03/15 09:00
entrez 2007/10/02 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Middelberg RP Middelberg Rita P S RP Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia. rita.middelberg@qimr.edu.au
Medland SE Medland Sarah E SE
Martin NG Martin Nicholas G NG
Whitfield JB Whitfield John B JB
INVESTIGATORS
JOURNAL
VOLUME: 10
ISSUE: 5
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2007
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Age Factors
Alanine Transaminase metabolism
Aspartate Aminotransferases metabolism
Environment metabolism
Female metabolism
Genetic Variation metabolism
Humans metabolism
Liver enzymology
Longitudinal Studies enzymology
Male enzymology
Multivariate Analysis enzymology
Twins, Dizygotic genetics
Twins, Monozygotic genetics
Uric Acid metabolism
gamma-Glutamyltransferase metabolism
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
268B43MJ25 Uric Acid
EC 2.3.2.2 gamma-Glutamyltransferase
EC 2.6.1.1 Aspartate Aminotransferases
EC 2.6.1.2 Alanine Transaminase
OTHER ID's