Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
17826493
TITLE
Significance of minute focus of adenocarcinoma on prostate needle biopsy.
ABSTRACT
OBJECTIVES NlmCategory: OBJECTIVE
To assess the radical prostatectomy findings in patients with a minute focus of adenocarcinoma on prostate needle biopsy in current practice in Australia.
METHODS NlmCategory: METHODS
A total of 58 patients with a 0.5-mm focus or less of Gleason score 6 adenocarcinoma on needle biopsy who had been treated by radical prostatectomy were selected. At each biopsy, 6 to 20 cores (mean 11, median 13) were taken. Significant tumors were those with a Gleason score of 6 or more and tumor volume of 0.5 cm3 or larger.
RESULTS NlmCategory: RESULTS
The 58 patients (mean age 50 years, median 58, range 44 to 69) had a mean prostate-specific antigen (PSA) level of 6.9 ng/mL (range 0.7 to 16, median 6). Of the 58 men, 48 (82.75%) had pathologically significant tumor, with 8 (13.8%) showing extraprostatic extension. No statistically significant association was found between significant carcinoma and age, mean PSA level, PSA density greater than 0.15, prior negative biopsy, coexistent atypical glands, or the number of tissue cores per biopsy. A prostate weight greater than 40 g correlated significantly with insignificant cancer on both univariate (P = 0.03) and multivariate (P = 0.02) analyses. In 14 (29.2%) of 48 patients with significant tumor, the largest cancer focus in the radical prostatectomy was anterior, lateral, or anterolateral. In patients without atypical glands, 37 (78.72%) of 47 had significant carcinoma, a risk not significantly lower than that of the entire group.
CONCLUSIONS NlmCategory: CONCLUSIONS
The results of our study have shown that in populations without PSA screening, a minute focus of prostate cancer on needle biopsy, even with extended biopsy cores, does not mean insignificant carcinoma in most cases. Patients with larger glands had a greater chance of insignificant cancer.
DATE PUBLISHED
2007 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2006/04/30
revised 2007/03/01
accepted 2007/03/28
pubmed 2007/09/11 09:00
medline 2007/10/04 09:00
entrez 2007/09/11 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Samaratunga H Samaratunga Hemamali H Sullivan Nicolaides Pathology, Brisbane, Queensland, Australia. hema_samaratunga@snp.com.au
Yaxley J Yaxley John J
Kerr K Kerr Kris K
McClymont K McClymont Kelly K
Duffy D Duffy David D
INVESTIGATORS
JOURNAL
VOLUME: 70
ISSUE: 2
TITLE: Urology
ISOABBREVIATION: Urology
YEAR: 2007
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1527-9995
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Urology
COUNTRY: United States
ISSNLINKING: 0090-4295
NLMUNIQUEID: 0366151
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adenocarcinoma pathology
Adult pathology
Aged pathology
Biopsy, Needle pathology
Humans pathology
Male pathology
Middle Aged pathology
Prognosis pathology
Prostatic Neoplasms pathology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's