Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
17687451
TITLE
Evidence of genetic effects on blood lead concentration.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Lead is an environmental pollutant that causes acute and chronic toxicity. Surveys have related mean blood lead concentrations to exogenous sources, including industrial activity, use of lead-based paints, or traffic density. However, there has been little investigation of individual differences in lead absorption, distribution, or toxicity, or of genetic causes of such variation.
OBJECTIVES NlmCategory: OBJECTIVE
We assessed the genetic contribution to variation in blood lead concentration in adults and conducted a preliminary search for genes producing such variation.
METHODS NlmCategory: METHODS
Erythrocyte lead concentration was measured by inductively coupled plasma mass spectrometry in venous blood samples from 2,926 Australian adult male and female twins. Mean lead concentrations were compared by place of residence, social class and education, and by the subjects' age, sex, alcohol intake, smoking habits, iron status, and HFE genotype.
RESULTS NlmCategory: RESULTS
After adjustment for these covariates, there was strong evidence of genetic effects but not for shared environmental effects persisting into adult life. Linkage analysis showed suggestive evidence (logarithm of odds = 2.63, genome-wide p = 0.170) for a quantitative trait locus affecting blood lead values on chromosome 3 with the linkage peak close to SLC4A7, a gene whose product affects lead transport.
CONCLUSIONS NlmCategory: CONCLUSIONS
We conclude that genetic variation plays a significant role in determining lead absorption, lead distribution within the body, or both.
DATE PUBLISHED
2007 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2005/11/14
accepted 2007/06/14
pubmed 2007/08/10 09:00
medline 2007/10/03 09:00
entrez 2007/08/10 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Whitfield JB Whitfield John B JB Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, Australia. John.Whitfield@email.cs.nsw.gov.au
Dy V Dy Veronica V
McQuilty R McQuilty Robert R
Zhu G Zhu Gu G
Montgomery GW Montgomery Grant W GW
Ferreira MA Ferreira Manuel A R MA
Duffy DL Duffy David L DL
Neale MC Neale Michael C MC
Heijmans BT Heijmans Bas T BT
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 115
ISSUE: 8
TITLE: Environmental health perspectives
ISOABBREVIATION: Environ. Health Perspect.
YEAR: 2007
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0091-6765
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Environ Health Perspect
COUNTRY: United States
ISSNLINKING: 0091-6765
NLMUNIQUEID: 0330411
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA007535 NIAAA NIH HHS United States
AA007728 NIAAA NIH HHS United States
AA011998 NIAAA NIH HHS United States
AA013320 NIAAA NIH HHS United States
AA013326 NIAAA NIH HHS United States
AA014041 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Alcohol Drinking
Australia
Chromosomes, Human, Pair 3 genetics
Environmental Pollutants blood
Female blood
Ferritins blood
Genetic Linkage blood
Genetic Variation blood
Genotype blood
Histocompatibility Antigens Class I genetics
Humans genetics
Iron blood
Lead blood
Male blood
Membrane Proteins genetics
Middle Aged genetics
Quantitative Trait Loci genetics
Sodium-Bicarbonate Symporters genetics
Transferrin metabolism
Twins genetics
Uric Acid blood
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Environmental Pollutants
0 HFE protein, human
0 Histocompatibility Antigens Class I
0 Membrane Proteins
0 SLC4A7 protein, human
0 Sodium-Bicarbonate Symporters
0 Transferrin
268B43MJ25 Uric Acid
2P299V784P Lead
9007-73-2 Ferritins
E1UOL152H7 Iron
OTHER ID's
OTHERID SOURCE
PMC1940084 NLM