Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
17680356
TITLE
Estimation of variance components for age at menarche in twin families.
ABSTRACT
Age at menarche (AAM), time of first menstrual period, is an important developmental milestone in females. Follow-up data from 1,302 adolescent twins and their sisters were used to partition the normal variation in AAM. The proportion of censoring was 14.1%. Both a standard and a survival analysis method were used. The best fitting model from the survival analysis method was an ACE model, where 57% and 23% of the variance in AAM was explained by additive genetic and environmental effects, respectively. The best fitting model when using a standard variance decomposition method was an AE model, where 82% of the variance was explained by additive genetic effects. The lack of correspondence between the results of the two methods was an artefact of the different ascertainment of AAM reports from siblings and twins. After the removal of the sibling sample, both methods indicated that an ACE model was the most likely. Standard and survival analysis methods estimated the proportion of variance explained by additive effects to be 0.50 and 0.54, and common environmental effects to be 0.31 and 0.29, respectively. We conclude that variation in AAM can be explained by additive genetic and common environmental components.
DATE PUBLISHED
2007 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2006/12/07
accepted 2007/07/04
aheadofprint 2007/08/07
pubmed 2007/08/08 09:00
medline 2008/01/19 09:00
entrez 2007/08/08 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Anderson CA Anderson Carl A CA Genetic Epidemiology Group, Queensland Institute of Medical Research, Brisbane 4029, Australia. carl.anderson@well.ox.ac.uk
Duffy DL Duffy David L DL
Martin NG Martin Nicholas G NG
Visscher PM Visscher Peter M PM
INVESTIGATORS
JOURNAL
VOLUME: 37
ISSUE: 5
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2007
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0001-8244
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
CA88363 NCI NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Age Factors
Analysis of Variance
Child
Family
Female
Humans
Interviews as Topic
Male
Menarche genetics
Models, Genetic genetics
Nuclear Family genetics
Siblings genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's