Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
17597587
TITLE
A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
KIAA0319 (6p22.2) has recently been implicated as a susceptibility gene for dyslexia. We aimed to find further support for this gene by examining its association with reading and spelling ability in adolescent twins and their siblings unselected for dyslexia.
METHODS NlmCategory: METHODS
Ten single nucleotide polymorphisms (SNPs) in or near the KIAA0319 gene were typed in 440 families with up to five offspring who had been tested on reading and spelling tasks. Family-based association analyses were performed, including a univariate analysis of the principal component reading and spelling score derived from the Components of Reading Examination (CORE) test battery and a bivariate analysis of whole-word reading tests measured in a slightly larger sample.
RESULTS NlmCategory: RESULTS
Significant association with rs2143340 (TTRAP) and rs6935076 (KIAA0319) and with a three-SNP haplotype spanning KIAA0319 and TTRAP was observed. The association with rs2143340 was found in both analyses, although the effect was in the opposite direction to that previously reported. The effect of rs6935076 on the principal component was in the same direction as past findings. Two of the three significant individual haplotypes showed effects in the opposite direction to the two prior reports.
CONCLUSIONS NlmCategory: CONCLUSIONS
These results suggest that a multilocus effect in or near KIAA0319 may influence variation in reading ability.
DATE PUBLISHED
2007 Oct 1
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2006/03/15
revised 2006/09/12
accepted 2006/10/30
aheadofprint 2007/06/27
pubmed 2007/06/29 09:00
medline 2007/10/30 09:00
entrez 2007/06/29 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Luciano M Luciano Michelle M Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia. michelle.luciano@qimr.edu.au
Lind PA Lind Penelope A PA
Duffy DL Duffy David L DL
Castles A Castles Anne A
Wright MJ Wright Margaret J MJ
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
Bates TC Bates Timothy C TC
INVESTIGATORS
JOURNAL
VOLUME: 62
ISSUE: 7
TITLE: Biological psychiatry
ISOABBREVIATION: Biol. Psychiatry
YEAR: 2007
MONTH: Oct
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0006-3223
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Biol Psychiatry
COUNTRY: United States
ISSNLINKING: 0006-3223
NLMUNIQUEID: 0213264
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Alleles
Data Interpretation, Statistical
Dyslexia psychology
Female psychology
Gene Frequency psychology
Genotype psychology
Haplotypes psychology
Humans psychology
Male psychology
Nerve Tissue Proteins genetics
Neuropsychological Tests genetics
Nuclear Proteins genetics
Phenotype genetics
Polymorphism, Single Nucleotide genetics
Psychomotor Performance physiology
Reading physiology
Transcription Factors genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 KIAA0319 protein, human
0 Nerve Tissue Proteins
0 Nuclear Proteins
0 TDP2 protein, human
0 Transcription Factors
OTHER ID's