Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
17439340
TITLE
Toward standardization of carbohydrate-deficient transferrin (CDT) measurements: I. Analyte definition and proposal of a candidate reference method.
ABSTRACT
An alcohol-associated change in the serum transferrin glycoform pattern, carbohydrate-deficient transferrin (CDT), is used as a biomarker of chronic moderate to heavy alcohol consumption. A current limitation in CDT analysis is the lack of standardization, which hampers clinical and analytical comparison between studies. This situation prompted initiation of a Working Group (WG) on CDT Standardization under the auspices of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The standardization work aims to define and validate the analyte, select a reference method, work out procedures for the production of reference materials, and make suggestions for the clinical usage of CDT. The first recommendation of the WG is that disialotransferrin should be the primary target molecule for CDT measurement and the single analyte on which CDT standardization is based. It is further recommended that HPLC should be the analytical principle considered as the basis of an interim reference method until a suitable mass spectrometric reference method is established. In clinical use, CDT should be expressed in a relative amount (% CDT), to compensate for variations in the total transferrin concentration.
DATE PUBLISHED
2007
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2007/04/19 09:00
medline 2007/06/15 09:00
entrez 2007/04/19 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Jeppsson JO Jeppsson Jan-Olof JO Malmö University Hospital, Malmö, Sweden.
Arndt T Arndt Torsten T
Schellenberg F Schellenberg François F
Wielders JP Wielders Jos P M JP
Anton RF Anton Raymond F RF
Whitfield JB Whitfield John B JB
Helander A Helander Anders A
International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Standardization of Carbohydrate-deficient Transferin (IFCC-WG-CDT)
INVESTIGATORS
JOURNAL
VOLUME: 45
ISSUE: 4
TITLE: Clinical chemistry and laboratory medicine
ISOABBREVIATION: Clin. Chem. Lab. Med.
YEAR: 2007
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1434-6621
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Clin Chem Lab Med
COUNTRY: Germany
ISSNLINKING: 1434-6621
NLMUNIQUEID: 9806306
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
CommentIn Clin Chem Lab Med. 2008;46(5):725-6; author reply 727-8 18839475
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Humans
Reference Standards
Transferrin standards
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Transferrin
0 carbohydrate-deficient transferrin
OTHER ID's