Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
17325240
TITLE
Genome-wide scan for blood pressure in Australian and Dutch subjects suggests linkage at 5P, 14Q, and 17P.
ABSTRACT
Large-scale studies estimate the heritability of blood pressure at approximately 50%. We carried out a genome-wide linkage analysis to search for chromosomal loci that might explain this heritability using longitudinal, multiple measures of systolic and diastolic blood pressure obtained in sibling pairs and dizygotic twin pairs from 2 countries (a total of 286 pairs from Australia and 636 pairs from the Netherlands). These pairs and a large number of their parents were genotyped with microsatellite markers. Multivariate linkage analysis of the combined data of both countries, using a variance components approach, showed suggestive linkage for diastolic blood pressure on chromosomes 5p13.1 (logarithm of odds score: 2.48), 14q12 (logarithm of odds score: 2.40) and 17q24.3 (logarithm of odds score: 2.36). The highest logarithm of odds score of 1.21 for systolic blood pressure was observed on chromosome 13q34. These results replicate earlier findings and add to a slowly emerging picture of multiple loci contributing to quantitative blood pressure variation.
DATE PUBLISHED
2007 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2007/02/26
pubmed 2007/02/28 09:00
medline 2007/04/06 09:00
entrez 2007/02/28 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hottenga JJ Hottenga Jouke-Jan JJ Department of Biological Psychology and the Center for Neurogenomics and Clinical Research, Vrije Universiteit, Amsterdam, The Netherlands. jj.hottenga@psy.vu.nl
Whitfield JB Whitfield John B JB
Posthuma D Posthuma Danielle D
Willemsen G Willemsen Gonneke G
de Geus EJ de Geus Eco J C EJ
Martin NG Martin Nicholas G NG
Boomsma DI Boomsma Dorret I DI
INVESTIGATORS
JOURNAL
VOLUME: 49
ISSUE: 4
TITLE: Hypertension
ISOABBREVIATION: Hypertension
YEAR: 2007
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1524-4563
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Hypertension
COUNTRY: United States
ISSNLINKING: 0194-911X
NLMUNIQUEID: 7906255
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
CA75581 NCI NIH HHS United States
DA00272 NIDA NIH HHS United States
DA12540 NIDA NIH HHS United States
DA12854 NIDA NIH HHS United States
R01 MH059160 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Australia
Blood Pressure genetics
Chromosome Mapping genetics
Chromosomes, Human, Pair 14 genetics
Chromosomes, Human, Pair 17 genetics
Chromosomes, Human, Pair 5 genetics
Diastole genetics
European Continental Ancestry Group genetics
Female genetics
Genetic Linkage genetics
Genome, Human genetics
Genotype genetics
Humans genetics
Lod Score genetics
Longitudinal Studies genetics
Male genetics
Microsatellite Repeats genetics
Middle Aged genetics
Netherlands genetics
Siblings genetics
Systole genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's