Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
16848784
TITLE
Effect of the BDNF V166M polymorphism on working memory in healthy adolescents.
ABSTRACT
Brain-derived neurotrophic factor (BDNF) may play a role in modulating memory function and there is growing evidence that the BDNF V166M polymorphism may influence episodic memory in humans. However, previous association studies examining this polymorphism and working memory are inconsistent. The current study examined this association in a large sample of adolescent twin-pairs and siblings (785 individuals from 439 families). A range of measures (event-related potential, general performance and reaction time) was obtained from a delayed-response working-memory task and total association was examined using the quantitative transmission disequilibrium tests (QTDT) program. Analyses had approximately 93-97% power (alpha= 0.05) to detect an association accounting for as little as 2% of the variance in the phenotypes examined. Results indicated that the BDNF V166M polymorphism is not associated with variation in working memory in healthy adolescents.
DATE PUBLISHED
2007 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2006/07/17
pubmed 2006/07/20 09:00
medline 2007/08/30 09:00
entrez 2006/07/20 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hansell NK Hansell N K NK Genetic Epidemiology, Queensland Institute of Medical Research, University of Queensland, Brisbane, Australia. Narelle.Hansell@qimr.edu.au
James MR James M R MR
Duffy DL Duffy D L DL
Birley AJ Birley A J AJ
Luciano M Luciano M M
Geffen GM Geffen G M GM
Wright MJ Wright M J MJ
Montgomery GW Montgomery G W GW
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 6
ISSUE: 3
TITLE: Genes, brain, and behavior
ISOABBREVIATION: Genes Brain Behav.
YEAR: 2007
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1601-1848
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Genes Brain Behav
COUNTRY: England
ISSNLINKING: 1601-183X
NLMUNIQUEID: 101129617
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Brain-Derived Neurotrophic Factor metabolism
Chi-Square Distribution metabolism
Event-Related Potentials, P300 physiology
Female physiology
Humans physiology
Linkage Disequilibrium physiology
Memory, Short-Term physiology
Polymorphism, Single Nucleotide physiology
Reaction Time physiology
Reference Values physiology
Siblings physiology
Statistics, Nonparametric physiology
Twins, Dizygotic metabolism
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Brain-Derived Neurotrophic Factor
OTHER ID's