Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
16828726
TITLE
Genome-wide linkage scan for loci influencing plasma triglycerides.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Plasma triglyceride concentration is known to be a significant risk factor for cardiovascular disease (CVD). Previous studies have found that the level of triglycerides is strongly influenced by genetic factors.
METHODS NlmCategory: METHODS
To identify quantitative trait loci influencing triglycerides, we conducted a genome-wide linkage scan on data from 485 Australian adult dizygotic twin pairs. Prior to linkage analysis, triglyceride values were adjusted for the effects of covariates including age, sex, time since last meal, time of blood collection (CT) and time to plasma separation.
RESULTS NlmCategory: RESULTS
The heritability estimate for ln(triglyceride) adjusted for all above fixed effects was 0.49. The highest multipoint LOD score observed was 2.94 (genome-wide p=0.049) on chromosome 7 (at 65 cM). This 7p region contains several candidate genes. Two other regions with suggestive multipoint LOD scores were also identified on chromosome 4 (LOD score=2.26 at 62 cM) and chromosome X (LOD score=2.01 at 81 cM).
CONCLUSIONS NlmCategory: CONCLUSIONS
The linkage peaks found represent newly identified regions for more detailed study, in particular the significant linkage observed on chromosome 7p13.
DATE PUBLISHED
2006 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2006/03/01
revised 2006/05/26
accepted 2006/05/26
aheadofprint 2006/06/03
pubmed 2006/07/11 09:00
medline 2007/03/17 09:00
entrez 2006/07/11 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Middelberg RP Middelberg Rita P RP Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. ritaM@qimr.edu.au
Martin NG Martin Nicholas G NG
Montgomery GW Montgomery Grant W GW
Whitfield JB Whitfield John B JB
INVESTIGATORS
JOURNAL
VOLUME: 374
ISSUE: 1-2
TITLE: Clinica chimica acta; international journal of clinical chemistry
ISOABBREVIATION: Clin. Chim. Acta
YEAR: 2006
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0009-8981
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Clin Chim Acta
COUNTRY: Netherlands
ISSNLINKING: 0009-8981
NLMUNIQUEID: 1302422
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA007535 NIAAA NIH HHS United States
AA014041 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Aged, 80 and over
Australia
Chromosomes, Human, Pair 7 genetics
Female genetics
Genetic Linkage genetics
Genome, Human genetics
Humans genetics
Lod Score genetics
Male genetics
Middle Aged genetics
Quantitative Trait Loci genetics
Triglycerides blood
Twins, Dizygotic blood
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Triglycerides
OTHER ID's