Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
16792555
TITLE
Effects of variation at the ALDH2 locus on alcohol metabolism, sensitivity, consumption, and dependence in Europeans.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
The low-activity variant of the aldehyde dehydrogenase 2 (ALDH2) gene found in East Asian populations leads to the alcohol flush reaction and reduces alcohol consumption and risk of alcohol dependence (AD). We have tested whether other polymorphisms in the ALDH2 gene have similar effects in people of European ancestry.
METHODS NlmCategory: METHODS
Serial measurements of blood and breath alcohol, subjective intoxication, body sway, skin temperature, blood pressure, and pulse were obtained in 412 twins who took part in an alcohol challenge study. Participants provided data on alcohol reactions, alcohol consumption, and symptoms related to AD at the time of the study and subsequently. Haplotypes based on 5 single-nucleotide polymorphisms (SNPs) were used in tests of the effects of variation in the ALDH2 gene on alcohol metabolism and alcohol's effects.
RESULTS NlmCategory: RESULTS
The typed SNPs were in strong linkage disequilibrium and 2 complementary haplotypes comprised 83% of those observed. Significant effects of ALDH2 haplotype were observed for breath alcohol concentration, with similar but smaller and nonsignificant effects on blood alcohol. Haplotype-related variation in responses to alcohol, and reported alcohol consumption, was small and not consistently in the direction predicted by the effects on alcohol concentrations.
CONCLUSIONS NlmCategory: CONCLUSIONS
Genetic variation in ALDH2 affects alcohol metabolism in Europeans. However, the data do not support the hypothesis that this leads to effects on alcohol sensitivity, consumption, or risk of dependence.
DATE PUBLISHED
2006 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2006/06/24 09:00
medline 2006/10/18 09:00
entrez 2006/06/24 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Dickson PA Dickson Peter A PA Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia.
James MR James Michael R MR
Heath AC Heath Andrew C AC
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
Whitfield JB Whitfield John B JB
Birley AJ Birley Andrew J AJ
INVESTIGATORS
JOURNAL
VOLUME: 30
ISSUE: 7
TITLE: Alcoholism, clinical and experimental research
ISOABBREVIATION: Alcohol. Clin. Exp. Res.
YEAR: 2006
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0145-6008
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Alcohol Clin Exp Res
COUNTRY: England
ISSNLINKING: 0145-6008
NLMUNIQUEID: 7707242
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Alcohol Drinking genetics
Alcoholic Intoxication genetics
Alcoholism genetics
Aldehyde Dehydrogenase genetics
Blood Pressure drug effects
Ethanol pharmacology
European Continental Ancestry Group genetics
Haplotypes genetics
Heart Rate drug effects
Humans drug effects
Linkage Disequilibrium drug effects
Polymorphism, Single Nucleotide drug effects
Postural Balance drug effects
Skin Temperature drug effects
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
3K9958V90M Ethanol
EC 1.2.1.3 ALDH2 protein, human
EC 1.2.1.3 Aldehyde Dehydrogenase
OTHER ID's