Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
16341610
TITLE
Genome-wide scan of IQ finds significant linkage to a quantitative trait locus on 2q.
ABSTRACT
A genome-wide linkage scan of 795 microsatellite markers (761 autosomal, 34 X chromosome) was performed on Multidimensional Aptitude Battery subtests and verbal, performance and full scale scores, the WAIS-R Digit Symbol subtest, and two word-recognition tests (Schonell Graded Word Reading Test, Cambridge Contextual Reading Test) highly predictive of IQ. The sample included 361 families comprising 2-5 siblings who ranged in age from 15.7 to 22.2 years; genotype, but not phenotype, data were available for 81% of parents. A variance components analysis which controlled for age and sex effects showed significant linkage for the Cambridge reading test and performance IQ to the same region on chromosome 2, with respective LOD scores of 4.15 and 3.68. Suggestive linkage (LOD score>2.2) for various measures was further supported on chromosomes 6, 7, 11, 14, 21 and 22. Where location of linkage peaks converged for IQ subtests within the same scale, the overall scale score provided increased evidence for linkage to that region over any individual subtest. Association studies of candidate genes, particularly those involved in neural transmission and development, will be directed to genes located under the linkage peaks identified in this study.
DATE PUBLISHED
2006 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2005/02/06
accepted 2005/06/20
aheadofprint 2005/12/09
pubmed 2005/12/13 09:00
medline 2006/10/06 09:00
entrez 2005/12/13 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Luciano M Luciano M M Queensland Institute of Medical Research, Herston, Brisbane, Australia. michelle.luciano@qimr.edu.au
Wright MJ Wright M J MJ
Duffy DL Duffy D L DL
Wainwright MA Wainwright M A MA
Zhu G Zhu G G
Evans DM Evans D M DM
Geffen GM Geffen G M GM
Montgomery GW Montgomery G W GW
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 36
ISSUE: 1
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2006
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0001-8244
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Chromosome Mapping
Chromosomes, Human, Pair 2
Cognition
Female
Genetic Linkage
Genome, Human
Genotype
Humans
Intelligence genetics
Intelligence Tests genetics
Lod Score genetics
Male genetics
Mathematics genetics
Microsatellite Repeats genetics
Quantitative Trait Loci genetics
Siblings genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
Vocabulary genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's