Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
16331531
TITLE
Linkage analyses of event-related potential slow wave phenotypes recorded in a working memory task.
ABSTRACT
Working memory is an essential component of wide-ranging cognitive functions. It is a complex genetic trait probably influenced by numerous genes that individually have only a small influence. These genes may have an amplified influence on phenotypes closer to the gene action. In this study, event-related potential (ERP) phenotypes recorded during a working-memory task were collected from 656 adolescents from 299 families for whom genotypes were available. Univariate linkage analyses using the MERLIN variance-components method were conducted on slow wave phenotypes recorded at multiple sites while participants were required to remember the location of a target. Suggestive linkage (LOD > 2.2) was found on chromosomes 4, 5, 6, 10, 17, and 20. After correcting for multiple testing, suggestive linkage remained on chromosome 10. Empirical thresholds were computed for the most promising phenotypes. Those on chromosome 10 remained suggestive. A number of genes reported to regulate neural differentiation and function (i.e. NRP1, ANK3, and CHAT) were found under these linkage peaks and may influence the levels of neural activity occurring in individuals participating in a spatial working-memory task.
DATE PUBLISHED
2006 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2005/02/07
accepted 2005/06/20
aheadofprint 2005/12/06
pubmed 2005/12/07 09:00
medline 2006/10/06 09:00
entrez 2005/12/07 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hansell NK Hansell N K NK Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.
Medland SE Medland S E SE
Ferreira MA Ferreira M A R MA
Geffen GM Geffen G M GM
Zhu G Zhu G G
Montgomery GW Montgomery G W GW
Duffy DL Duffy D L DL
Wright MJ Wright M J MJ
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 36
ISSUE: 1
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2006
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0001-8244
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Analysis of Variance
Chromosome Mapping
Computer Simulation
Evoked Potentials genetics
Female genetics
Genotype genetics
Humans genetics
Lod Score genetics
Male genetics
Memory physiology
Phenotype physiology
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's