Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
16079647
TITLE
Evidence of age-dependent genetic influences on plasma total cholesterol.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Causes of variation in cardiovascular risk factors include biological variation within individuals, and more permanent differences between individuals, which are at least partly genetic in origin. We have compared the magnitude of genetic and non-genetic factors within and across occasions through repeated measures of plasma cholesterol in twin subjects, and have also determined how far the same genes affect cholesterol levels at different ages.
METHODS NlmCategory: METHODS
Data on plasma total cholesterol were extracted for 208 twin pairs who had provided blood on up to six occasions across a period of 17 years. They were aged 18-30 years at the time of first study and 30-47 at the time of the last. Multivariate models of variation due to genetic, shared environmental and unique environmental factors were fitted to the multi-occasion data and the proportions of variation due to these factors were estimated.
RESULTS NlmCategory: RESULTS
One genetic factor influenced plasma cholesterol on all occasions and a second genetic factor only influenced cholesterol results on the fifth and sixth occasions 10-17 years after the first. Environmental factors did not have significant long-term effects.
CONCLUSIONS NlmCategory: CONCLUSIONS
We conclude that individuals' long-term mean plasma cholesterol values are strongly genetically determined, but that some of these genes are age-specific in their effects.
DATE PUBLISHED
2005 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2005/08/05 09:00
medline 2006/07/15 09:00
entrez 2005/08/05 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Middelberg R Middelberg Rita R Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia.
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
Whitfield JB Whitfield John B JB
INVESTIGATORS
JOURNAL
VOLUME: 12
ISSUE: 4
TITLE: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
ISOABBREVIATION: Eur J Cardiovasc Prev Rehabil
YEAR: 2005
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1741-8267
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Eur J Cardiovasc Prev Rehabil
COUNTRY: England
ISSNLINKING: 1741-8267
NLMUNIQUEID: 101192000
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA007535 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aging blood
Australia epidemiology
Biological Markers blood
Cholesterol genetics
Evidence-Based Medicine genetics
Female genetics
Genetic Variation genetics
Humans genetics
Male genetics
Multivariate Analysis genetics
Phenotype genetics
Twin Studies as Topic genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Biological Markers
97C5T2UQ7J Cholesterol
OTHER ID's