Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
15987731
TITLE
Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review.
ABSTRACT
A number of studies have investigated two common polymorphisms in the beta(2)-adrenoceptor gene, Arg/Gly16 and Gln/Glu27, in relation to asthma susceptibility. The authors performed a meta-analysis of each polymorphism, as well as haplotype analysis, for adult and pediatric populations separately, using published data, supplemented by additional data requested from the original authors. Individual analysis detected no effect of Arg/Gly16 in adults but did suggest a recessive protective effect of Gly16 for children, with an odds ratio of 0.71 (95% confidence interval (CI): 0.53, 0.96) compared with the other genotypes. Results for Gln/Glu27 in adults seem to indicate that heterozygotes are at decreased risk of asthma than either homozygote (odds ratio = 0.73, 95% CI: 0.62, 0.87), although the studies are heterogeneous; in children, the Glu/Glu genotype has a decreased risk of asthma (odds ratio = 0.60, 95% CI: 0.35, 0.99) compared with the other genotypes. Despite the proximity of these two polymorphic sites, the linkage disequilibrium coefficient of 0.41 was not high (p < 0.001). Haplotype analysis suggests that there may be an interaction between the two sites, with a lower risk of asthma associated with the Glu27 allele (compared with Gln27), and that this risk is modified by the allele at position 16.
DATE PUBLISHED
2005 Aug 1
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2005/06/29
pubmed 2005/07/01 09:00
medline 2005/09/09 09:00
entrez 2005/07/01 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Thakkinstian A Thakkinstian Ammarin A Clinical Epidemiology Unit, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
McEvoy M McEvoy Mark M
Minelli C Minelli Cosetta C
Gibson P Gibson Peter P
Hancox B Hancox Bob B
Duffy D Duffy David D
Thompson J Thompson John J
Hall I Hall Ian I
Kaufman J Kaufman Joel J
Leung TF Leung Ting-Fan TF
Helms PJ Helms Peter Joseph PJ
Hakonarson H Hakonarson Hakon H
Halpi E Halpi Eva E
Navon R Navon Ruth R
Attia J Attia John J
INVESTIGATORS
JOURNAL
VOLUME: 162
ISSUE: 3
TITLE: American journal of epidemiology
ISOABBREVIATION: Am. J. Epidemiol.
YEAR: 2005
MONTH: Aug
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0002-9262
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Am J Epidemiol
COUNTRY: United States
ISSNLINKING: 0002-9262
NLMUNIQUEID: 7910653
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Review
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Alleles
Asthma genetics
Genetic Predisposition to Disease genetics
Genotype genetics
Haplotypes genetics
Humans genetics
Linkage Disequilibrium genetics
Polymorphism, Genetic genetics
Receptors, Adrenergic, beta-2 genetics
Risk Assessment genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Receptors, Adrenergic, beta-2
OTHER ID's