Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
15842033
TITLE
The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Serotonin is a good candidate for major depression. We attempted to replicate the study by Caspi and colleagues [Science (2003) 301, 386-389] which reported a significant interaction between serotonin transporter (5-HTTLPR) genotype and stressful life events when predicting major depression.
METHOD NlmCategory: METHODS
We typed the serotonin promoter 5-HTTLPR gene in 1206 male and female twins aged 19-78 years (mean = 39, S.D. = 11). A DSM-IV diagnosis of major depression was available for 1199 twins. Most of these twins had participated in a 1988-1990 study which included a stressful life events inventory and self-report measure of depression based on the SCL-90 and DSSI/sAD. Complete 5-HTT genotype and life events data, self-report symptoms and major depression diagnoses were available for 1091 subjects. We regressed categorical and ordinal measures of depression onto stressful life events and genotype.
RESULTS NlmCategory: RESULTS
There were significant main effects for stressful life events but there was no evidence for any effect of 5-HTT genotype, nor a genotype x stressful life event interaction.
CONCLUSIONS NlmCategory: CONCLUSIONS
Regardless of whether our results were based on binary logistic or ordinal regression analyses we found no evidence to support a main effect of 5-HTTLPR, or an interaction between the 5-HTTLPR genotype and stressful life events on major depression, Only 20 % of our subjects were aged below 30 years. It is possible that the effect reported by Caspi and colleagues is specific to young people, in which case our study has much less power in this age group.
DATE PUBLISHED
2005 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2005/04/22 09:00
medline 2005/05/18 09:00
entrez 2005/04/22 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Gillespie NA Gillespie Nathan A NA Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Australia. nathanG@qimr.edu.au
Whitfield JB Whitfield John B JB
Williams B Williams Ben B
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 35
ISSUE: 1
TITLE: Psychological medicine
ISOABBREVIATION: Psychol Med
YEAR: 2005
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0033-2917
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Psychol Med
COUNTRY: England
ISSNLINKING: 0033-2917
NLMUNIQUEID: 1254142
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
MH31302 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Aged
Depressive Disorder, Major genetics
Diagnostic and Statistical Manual of Mental Disorders genetics
Female genetics
Genotype genetics
Humans genetics
Interview, Psychological genetics
Life Change Events genetics
Male genetics
Membrane Glycoproteins genetics
Membrane Transport Proteins genetics
Middle Aged genetics
Nerve Tissue Proteins genetics
Regression Analysis genetics
Serotonin Plasma Membrane Transport Proteins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Membrane Glycoproteins
0 Membrane Transport Proteins
0 Nerve Tissue Proteins
0 SLC6A4 protein, human
0 Serotonin Plasma Membrane Transport Proteins
OTHER ID's