Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
1575585
TITLE
Genetic control of the renal clearance of urate: a study of twins.
ABSTRACT
Although a genetic predisposition to gout has been recognised for centuries, its mechanism has never been defined. This study was designed to determine whether this factor might be the renal clearance of urate, which is an important determinant of the concentration of urate in serum. In this study the renal clearance of urate was examined in 37 pairs of normouricaemic twins to determine whether this resemblance was genetically mediated. Monozygotic twins had more similar values of urate clearance and fractional excretion of urate than dizygotic twins. The heritability of the renal clearance of urate was estimated as about 60% (95% confidence limits 40 to 100%), whereas the heritability of the fractional excretion of urate was 87% (confidence limits 45 to 100%). This study supports the hypothesis that genetic factors exert an important control on the renal clearance of urate, which determines some of the familiarity of hyperuricaemia and gout.
DATE PUBLISHED
1992 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1992/03/01
medline 1992/03/01 00:01
entrez 1992/03/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Emmerson BT Emmerson B T BT Department of Medicine, University of Queensland, Woolloongabba, Australia.
Nagel SL Nagel S L SL
Duffy DL Duffy D L DL
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 51
ISSUE: 3
TITLE: Annals of the rheumatic diseases
ISOABBREVIATION: Ann. Rheum. Dis.
YEAR: 1992
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0003-4967
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Ann Rheum Dis
COUNTRY: England
ISSNLINKING: 0003-4967
NLMUNIQUEID: 0372355
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Creatinine urine
Female urine
Humans urine
Male urine
Middle Aged urine
Twins, Dizygotic genetics
Twins, Monozygotic genetics
Uric Acid urine
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
268B43MJ25 Uric Acid
AYI8EX34EU Creatinine
OTHER ID's
OTHERID SOURCE
PMC1004665 NLM