Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
15741437
TITLE
The CD14 C-159T polymorphism is not associated with asthma or asthma severity in an Australian adult population.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
CD14 functions as a multifunctional receptor for bacterial cell wall components including endotoxin and lipopolysaccharide and is likely to play a role in the polarisation of T lymphocytes into Th1 and Th2 subsets, thereby influencing the cytokine profile and subsequent IgE production in response to antigen/allergen contact in allergic phenotypes. A functional C-159T polymorphism has been described in the promoter region of the gene and has been associated with increased gene expression, atopy, and non-atopic asthma in different ethnic populations. A study was undertaken to examine the association between the C-159T polymorphism and asthma, asthma severity, and atopy in a large Australian white population.
METHODS NlmCategory: METHODS
PCR-RFLP analysis was used to characterise the C-159T polymorphism in mild (n = 264), moderate (n = 225) and severe (n = 79) asthmatic patients and non-asthmatic controls (n = 443), including atopic (n = 688) and non-atopic (n = 323) individuals. Association analyses were performed using chi(2) tests.
RESULTS NlmCategory: RESULTS
There was no association between the polymorphism and asthma (p = 0.468) or asthma severity (p = 0.727), and only a very weak association with atopy (p = 0.084). A meta-analysis of all studies conducted to date revealed similar genotypic frequencies in white ethnic populations and confirmed that there was no overall association with atopy (p = 0.52) or asthma (p = 0.23), although there was significant between study heterogeneity (p = 0.01).
CONCLUSIONS NlmCategory: CONCLUSIONS
This study confirms that there is no association between the CD14 C-159T polymorphism and asthma or asthma severity and a weak association between this polymorphism and atopy in an adult population.
DATE PUBLISHED
2005 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2005/03/03 09:00
medline 2005/03/23 09:00
entrez 2005/03/03 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Kedda MA Kedda M-A MA Asthma and Allergy Research Institute, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia.
Lose F Lose F F
Duffy D Duffy D D
Bell E Bell E E
Thompson PJ Thompson P J PJ
Upham J Upham J J
INVESTIGATORS
JOURNAL
VOLUME: 60
ISSUE: 3
TITLE: Thorax
ISOABBREVIATION: Thorax
YEAR: 2005
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0040-6376
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Thorax
COUNTRY: England
ISSNLINKING: 0040-6376
NLMUNIQUEID: 0417353
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Antigens, CD14 genetics
Asthma genetics
Australia epidemiology
Case-Control Studies epidemiology
Genotype epidemiology
Humans epidemiology
Hypersensitivity, Immediate genetics
Odds Ratio genetics
Polymorphism, Genetic genetics
Polymorphism, Restriction Fragment Length genetics
Regression Analysis genetics
Reverse Transcriptase Polymerase Chain Reaction genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Antigens, CD14
OTHER ID's
OTHERID SOURCE
PMC1747323 NLM