Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
15568190
TITLE
A method for meta-analysis of molecular association studies.
ABSTRACT
Although population-based molecular association studies are becoming increasingly popular, methodology for the meta-analysis of these studies has been neglected, particularly with regard to two issues: testing Hardy-Weinberg equilibrium (HWE), and pooling results in a manner that reflects a biological model of gene effect. We propose a process for pooling results from population-based molecular association studies which consists of the following steps: (1) checking HWE using chi-square goodness of fit; we suggest performing sensitivity analysis with and without studies that are in HWE. (2) Heterogeneity is then checked, and if present, possible causes are explored. (3) If no heterogeneity is present, regression analysis is used to pool data and to determine the gene effect. (4) If there is a significant gene effect, pairwise group differences are analysed and these data are allowed to 'dictate' the best genetic model. (5) Data may then be pooled using this model. This method is easily performed using standard software, and has the advantage of not assuming an a priori genetic model.
Copyright 2004 John Wiley & Sons, Ltd.
DATE PUBLISHED
2005 May 15
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2004/11/30 09:00
medline 2005/07/29 09:00
entrez 2004/11/30 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Thakkinstian A Thakkinstian Ammarin A Clinical Epidemiology Unit, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. raatk@mahidol.ac.th
McElduff P McElduff Patrick P
D'Este C D'Este Catherine C
Duffy D Duffy David D
Attia J Attia John J
INVESTIGATORS
JOURNAL
VOLUME: 24
ISSUE: 9
TITLE: Statistics in medicine
ISOABBREVIATION: Stat Med
YEAR: 2005
MONTH: May
DAY: 15
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0277-6715
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Stat Med
COUNTRY: England
ISSNLINKING: 0277-6715
NLMUNIQUEID: 8215016
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Bone Density physiology
Female physiology
Humans physiology
Meta-Analysis as Topic physiology
Models, Genetic physiology
Molecular Biology methods
Polymorphism, Genetic methods
Receptors, Calcitriol genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Receptors, Calcitriol
OTHER ID's