Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
15480322
TITLE
Major quantitative trait locus for eosinophil count is located on chromosome 2q.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Eosinophils are granulocytic white blood cells implicated in asthma and atopic disease. The degree of eosinophilia in the blood of patients with asthma correlates with the severity of asthmatic symptoms. Quantitative trait loci (QTL) linkage analysis of eosinophil count may be a more powerful strategy of mapping genes involved in asthma than linkage analysis using affected relative pairs.
OBJECTIVE NlmCategory: OBJECTIVE
To identify QTLs responsible for variation in eosinophil count in adolescent twins.
METHODS NlmCategory: METHODS
We measured eosinophil count longitudinally in 738 pairs of twins at 12, 14, and 16 years of age. We typed 757 highly polymorphic microsatellite markers at an average spacing of approximately 5 centimorgans across the genome. We then used multipoint variance components linkage analysis to test for linkage between marker loci and eosinophil concentrations at each age across the genome.
RESULTS NlmCategory: RESULTS
We found highly significant linkage on chromosome 2q33 in 12-year-old twins (logarithm of the odds=4.6; P=.000002) and suggestive evidence of linkage in the same region in 14-year-olds (logarithm of the odds=1.0; P=.016). We also found suggestive evidence of linkage at other areas of the genome, including regions on chromosomes 2, 3, 4, 8, 9, 11, 12, 17, 20, and 22.
CONCLUSION NlmCategory: CONCLUSIONS
A QTL for eosinophil count is present on chromosome 2q33. This QTL might represent a gene involved in asthma pathophysiology.
DATE PUBLISHED
2004 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2004/10/14 09:00
medline 2004/12/31 09:00
entrez 2004/10/14 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Evans DM Evans David M DM Queensland Institute of Medical Research and Joint Genetics Program, University of Queensland, Brisbane, Australia. davide@well.ox.ac.uk
Zhu G Zhu Gu G
Duffy DL Duffy David L DL
Montgomery GW Montgomery Grant W GW
Frazer IH Frazer Ian H IH
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 114
ISSUE: 4
TITLE: The Journal of allergy and clinical immunology
ISOABBREVIATION: J. Allergy Clin. Immunol.
YEAR: 2004
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0091-6749
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: J Allergy Clin Immunol
COUNTRY: United States
ISSNLINKING: 0091-6749
NLMUNIQUEID: 1275002
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
CA88363 NCI NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Child
Chromosome Mapping methods
Chromosomes, Human, Pair 2 genetics
Eosinophils physiology
Female physiology
Humans physiology
Male physiology
Quantitative Trait Loci genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's