Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
15306848
TITLE
A major quantitative trait locus for CD4-CD8 ratio is located on chromosome 11.
ABSTRACT
CD4-CD8 ratio is an important diagnostic measure of immune system functioning. In particular, CD4-CD8 ratio predicts the time taken for progression of HIV infection to acquired immune deficiency syndrome (AIDS) and the long-term survival of AIDS patients. To map genes that regulate differences between healthy individuals in CD4-CD8 ratio, we typed 757 highly polymorphic microsatellite markers at an average spacing of approximately 5 cM across the genome in 405 pairs of dizygotic twins at ages 12, 14 and 16. We used multipoint variance components linkage analysis to test for linkage between marker loci and CD4-CD8 ratio at each age. We found suggestive evidence of linkage on chromosome 11p in 12-year-old twins (LOD=2.55, P=0.00031) and even stronger evidence of linkage in the same region at age 14 (LOD=3.51, P=0.00003). Possible candidate genes include CD5 and CD6, which encode cell membrane proteins involved in the positive selection of thymocytes. We also found suggestive evidence of linkage at other areas of the genome including regions on chromosomes 1, 3, 4, 5, 6, 12, 13, 15, 17 and 22.
DATE PUBLISHED
2004 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2004/08/13 05:00
medline 2005/03/09 09:00
entrez 2004/08/13 05:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Evans DM Evans D M DM Queensland Institute of Medical Research, Brisbane, Australia. davide@well.ox.ac.uk
Zhu G Zhu G G
Duffy DL Duffy D L DL
Frazer IH Frazer I H IH
Montgomery GW Montgomery G W GW
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 5
ISSUE: 7
TITLE: Genes and immunity
ISOABBREVIATION: Genes Immun.
YEAR: 2004
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1466-4879
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Genes Immun
COUNTRY: England
ISSNLINKING: 1466-4879
NLMUNIQUEID: 100953417
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
CA88363 NCI NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
CD4-CD8 Ratio statistics & numerical data
Chi-Square Distribution statistics & numerical data
Child statistics & numerical data
Chromosomes, Human, Pair 11 genetics
Female genetics
Humans genetics
Lod Score genetics
Male genetics
Quantitative Trait Loci genetics
Twins, Dizygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's