Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
14681925
TITLE
Effects of dopamine receptor D4 variation on alcohol and tobacco use and on novelty seeking: multivariate linkage and association analysis.
ABSTRACT
The dopamine D4 receptor gene contains a polymorphic sequence consisting of a variable number of 48-base-pair (bp) repeats, and there have been a number of reports that this polymorphism is associated with variation in novelty seeking or in substance abuse and addictive behaviors. In this study we have assessed the linkage and association of DRD4 genotype with novelty seeking, alcohol use, and smoking in a sample of 377 dizygotic twin pairs and 15 single twins recruited from the Australian Twin Registry (ATR). We found no evidence of linkage or association of the DRD4 locus with any of the phenotypes. We made use of repeated measures for some phenotypes to increase power by multivariate genetic analysis, but allelic effects were still non-significant. Specifically, it has been suggested that the DRD4 7-repeat allele is associated with increased novelty seeking in males but we found no evidence for this, despite considerable power to do so. We conclude that DRD4 variation does not have an effect on use of alcohol and the problems that arise from it, on smoking, or on novelty seeking behavior.
Copyright 2003 Wiley-Liss, Inc.
DATE PUBLISHED
2004 Jan 1
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2003/12/19 05:00
medline 2004/07/29 05:00
entrez 2003/12/19 05:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Luciano M Luciano Michelle M Queensland Institute of Medical Research, Brisbane, Australia. michelLu@qimr.edu.au
Zhu G Zhu G G
Kirk KM Kirk K M KM
Whitfield JB Whitfield J B JB
Butler R Butler R R
Heath AC Heath A C AC
Madden PA Madden P A F PA
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 124B
ISSUE: 1
TITLE: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISOABBREVIATION: Am. J. Med. Genet. B Neuropsychiatr. Genet.
YEAR: 2004
MONTH: Jan
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1552-4841
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Am J Med Genet B Neuropsychiatr Genet
COUNTRY: United States
ISSNLINKING: 1552-4841
NLMUNIQUEID: 101235742
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Australia
Drinking Behavior
Female
Gene Frequency
Genetic Variation
Genotype
Humans
Linkage Disequilibrium
Male
Multivariate Analysis
Phenotype
Polymorphism, Genetic
Receptors, Dopamine D2 genetics
Receptors, Dopamine D4 genetics
Smoking genetics
Twins statistics & numerical data
Twins, Dizygotic statistics & numerical data
Twins, Monozygotic statistics & numerical data
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 DRD4 protein, human
0 Receptors, Dopamine D2
137750-34-6 Receptors, Dopamine D4
OTHER ID's